Relation between dietary n−3 and n−6 fatty acids and clinically diagnosed dry eye syndrome in women

Abstract

These results suggest that a higher dietary intake of n-3 FAs is associated with a decreased incidence of DES in women. These findings are consistent with anecdotal clinical observations and postulated biological mechanisms.

Blepharokeratoconjunctivitis in childhood: corneal involvement and visual outcome

“…14,[19][20][21][22][23] Omega-3 supplementation may have an adjunctive effect on the management of MGD and inflammatory dry eye. [22][23][24][25][26][27][28][29][30][31] It has been shown that omega-3 modulate prostaglandin metabolism toward anti-inflammatory prostaglandin (PGE 3 ) synthesis due to competitive inhibition of the arachidonic acid pathway at the cyclo-and lipooxygenase level. 22,32,33 Therefore, increasing systemic levels of omega-3 free fatty acids (EFA) result in decreased production of prostaglandin-E2 (PGE 2 ) metabolites, thromboxane-A 2 , and leukotriene-B4, all of which have a proinflammatory profile.…”

Resolvin E1 Improves Tear Production and Decreases Inflammation in a Dry Eye Mouse Model

“…[38][39][40] The formation of resolvins and protectins may explain the findings in animal models and human observations that topical treatment or diets enriched with omega-3 fatty acids can decrease biological signs and symptoms of DE. 12,41 Additionally, the reported effects by RvE1 and neuroprotectin D1 on reepithelialization and lateral cell migration following corneal wounding, and prevention of corneal neovascularization by RvE1, may further add to a potential clinical treatment effect of resolvins in corneal disease. 13,33,36 In conclusion, our results demonstrate that the endogenous resolvin, RvE1 (RX-10001), decreases the inflammatory response, increases tear volume, and maintains corneal epithelial integrity in a DE mouse model.…”

“…11 The endogenous formation of resolvins may also explain the recently published data from the longitudinal women's health study in which women on a high daily diet of omega-3 polyunsaturated fatty acids had a lower frequency of DE symptoms than those on a more common regimen. 12 In addition to dampening antigen-dependent inflammation, RvE1 was recently demonstrated to promote host tissue cell survival during induced stress conditions (either oxidative stress or hypoxia/reoxygenation) by downregulating proapoptotic pathways, including caspases, and activating prosurvival pathways, including the PI3K/Akt pathway, a major regulator of cell survival. [13][14][15] RvE1 activation of the PI3K/Akt pathway may also explain its wound-closing properties, as demonstrated in the human corneal epithelial cell scratch wound assay.…”

Uso oral do óleo de linhaça (Linum usitatissimum) no tratamento do olhoseco de pacientesportadores da síndrome de Sjögren

“…O baixo índice de ácidos graxos na dieta ocidental em comparação com a oriental, assinala a possibilidade da prevenção de doenças que estariam ligadas à produção de tecido inflamatório, como o OS, por meio da suplementação de alimentos, tais como: óleo de semente de linhaça, nozes e vegetais foliáceos, muito presentes na dieta oriental (11) . O maior consumo de AGE tipo ômega 3 (n-3) está associado a uma menor incidência de OS em mulheres (12) . Os AGE contêm compostos antiinflamatórios naturais, com a propriedade de aliviar sintomas da artrite e de outras doenças auto-imunes (13) .…”