Uso oral do óleo de linhaça (Linum usitatissimum) no tratamento do olhoseco de pacientesportadores da síndrome de Sjögren

Pinheiro, M.; Santos, Procópio Miguel dos; Santos, Rosa Maria Nascimento dos; Barros, João; Passos, Luiz Fernando; Neto, José Cardoso

doi:10.1590/s0004-27492007000400016

Cited by 23 publications

(8 citation statements)

References 29 publications

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“…O uso tópico da formulação oftálmica e do óleo de linhaça rico em ômega 3 e 6 melhorou os sintomas associados à CCS com redução significativa da ocorrência de hiperemia conjuntival, secreção ocular e opacidade corneal, o que está de acordo com os relatos sobre o tratamento da CCS com melhora dos sinais clínicos com a formulação oftálmica tópica em cães (Kirk, 1984;Severin, 1995;Pickett, 2001;Andrade, 2008) e do uso de ômega 3 e 6 em animais de laboratório por via tópica (Rashid et al, 2008;Neves et al, 2013) e em humanos por via oral (Roncone et al, 2010;Pinheiro Jr. et al, 2007;Wojtowicz et al, 2011).…”

Section: Discussão E Conclusãounclassified

“…Outra forma de tratamento para a CCS, que vem se destacando em estudos recentes, é a utilização de ácidos graxos essenciais (AGE), ômega 3 (ω-3) e ômega 6 (ω-6), principalmente no tratamento de pacientes portadores de diversas formas de deficiência lacrimal, como na Síndrome de Sjögren humana, tanto em suplementação oral (Barabino et al, 2003;Mavragani et al, 2006;Pinheiro Jr. et al, 2007;Roncone et al, 2010;Wojtowicz et al, 2011), como em experimentos por via tópica em ratos (Rashid et al, 2008) e por via tópica e oral em coelhos (Neves et al, 2013). Os principais efeitos terapêuticos do ω-3 e ω-6 são imunomodulador e anti-inflamatório.…”

Section: Introductionunclassified

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Comparação entre dois protocolos de tratamento de ceratoconjuntivite seca experimentalmente induzida em coelhos

Motta

Yamasaki

Sanches

et al. 2014

Arq. Bras. Med. Vet. Zootec.

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 RESUMOO objetivo deste estudo foi avaliar e comparar a eficácia de dois protocolos de tratamento de ceratoconjuntivite seca (CCS) experimentalmente induzida em coelhos: uma formulação oftálmica tópica composta por álcool polivinílico 1,4%, adicionado com acetilcisteína 10% e pilocarpina 1% (AAP), e outro protocolo com o uso do óleo de semente de linhaça (OL) tópico em forma de colírio, durante 12 semanas. Foram utilizados 15 coelhos machos, adultos, da raça Nova Zelândia, alocados aleatoriamente em três grupos: grupo C (controle), grupo AAP (formulação oftálmica) e grupo L (OL tópica). Os animais foram avaliados semanalmente pelo teste lacrimal de Schirmer, teste de fluoresceína e teste de Rosa Bengala; uma vez por mês, pelo exame de citologia esfoliativa ocular; ao final do experimento, pela análise histopatológica da córnea e conjuntiva. Os resultados demonstraram que houve um aumento maior na produção lacrimal quando utilizada a formulação oftálmica, e uma resolução mais rápida das úlceras de córnea, bem como diminuição no número de células desvitalizadas quando utilizado o óleo de semente de linhaça, além de aumento no número de células caliciformes em ambos os grupos de tratamento. A associação desses dois protocolos pode ser no futuro uma alternativa no tratamento da CCS.Palavras-chave: ceratoconjuntivite seca, álcool polivinílico 1,4%, acetilcisteína 10%, pilocarpina 1%, óleo de linhaça ABSTRACT The objective of this study was to evaluate and compare the effectiveness of two treatment protocol of experimentally induced keratoconjunctivitis sicca (KCS) in rabbits, a topical ophthalmic formulation composed by 1.4% povinilic alcohol added with 10% acetylcysteine and 1% pilocarpine (AAP) and another protocol with the topical use of the linseed seed oil (LO) in eye drop form for 12 weeks. Fifteen male New Zealand white rabbits were aleatory allocated in 3 groups: Group C (Control), Group AAP (ophthalmic formulation) and Group L (LO topical

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Section: Discussão E Conclusãounclassified

Section: Introductionunclassified

Comparação entre dois protocolos de tratamento de ceratoconjuntivite seca experimentalmente induzida em coelhos

Motta

Yamasaki

Sanches

et al. 2014

Arq. Bras. Med. Vet. Zootec.

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“…As noted earlier, the so‐called dry eye condition has been widely reported to be associated with squamous metaplasia, a process by which the cells appear to be enlarged 11–28. Associated with this cell enlargement is a change in overall appearance in that the relative amount of cytoplasm surrounding the cell nucleus becomes conspicuously greater.…”

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confidence: 91%

Objective assessment of conjunctival squamous metaplasia by measures of cell and nucleus dimensions

Doughty

2011

Diagnostic Cytopathology

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The main aim of this work is to present a special method for conjunctival impression cytology (CIC) and objective measures of measure cell and nucleus dimensions. CIC using Millicell® Biopore filters was obtained from 50 Caucasian adults from the nasal bulbar conjunctiva. Giemsa-stained images of cells in a monolayer were photographed with a scale bar and projected at 1,500× to generate an overlay. Measures were made of both the long (L) and short (S) dimensions of the cells and the longest dimension of the nucleus (LN). The selected images comprised sets of 10 from different individuals, which had been assigned grades 0, 1, 2, or 3 and an additional grade 0.5. L ranged from 18.4 to 65.2 μm, S from 13.1 to 47.1 μm, to give average cell shape values (L:S ratio) of between 1.259 and 1.890. L and S were smallest for grade 0 cells (group mean 19.8 ± 1.1 and 14.8 ± 1.2 μm) and largest for grade 3 cells (group 51.2 ± 7.2 and 37.2 ± 4.7 μm), with no difference in L:S ratios across the cell grades. Longest dimension of the nucleus (NL) values ranged from 8.7 to 14.5 μm, with group mean values of 9.8 ± 0.6 μm for grade 0 cells and 12.9 ± 1.2 μm for grade 3 cells. NL was nonlinearly associated with L. Measures of conjunctival cell and nucleus dimensions can be used to objectively distinguish between cells assigned different grades of squamous metaplasia, with slight nucleus enlargement being the earliest detectable change (at grade 0.5).

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“…Both groups were given a prescription-only medical food supplement, Tears Again HYDRATE TM (OCuSOFT, Rosenberg, TX), consisting of four geltabs containing a total of 1000 mg of omega-3 EFAs derived from flaxseed oil and 500 mg of omega-6 EFAs (GLA) derived from evening primrose oil, both of which are microencapsulated in a proprietary liposome process designed to improve absorption. The amount of EFAs per food supplement serving is similar to that used in other research on evening primrose oil16 and identical to that used in other research on flaxseed oil 11…”

Section: Methodsmentioning

confidence: 92%

“…Studies have suggested that nutritional supplementation with omega-3 fatty acids is related to improvement in dry eye and may contribute to restoration of the lipid layer, decreased inflammation and apoptosis, and increased tear secretion 9–11. A recently published pilot study found that average tear production and tear volume was increased in a group of patients taking an omega-3 supplement containing both fish oil and flaxseed oil 12…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A

Jackson¹

2011

OPTH

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PurposeTo evaluate the effect of a new, prescription-only medical food supplement containing omega-3 and omega-6 essential fatty acids on dry eye signs and symptoms, with or without concomitant topical cyclosporine.MethodsA total of 43 subjects were randomized and followed for 6 months. Group 1 (n = 23) was assigned to take two soft geltabs of the medical food supplement by mouth twice daily for 6 months. Group 2 (n = 20) was directed to take the medical food supplement in the same manner, along with topical cyclosporine, instilled twice daily during the last 3 months of the study. Subjects were evaluated at baseline, month 1, month 3, and month 6. Primary outcome measures included tear breakup time (TBUT), conjunctival staining, corneal staining, and change in subjective symptoms.ResultsBoth groups had a statistically significant improvement in TBUT between baseline and month 6. In the food supplement only group, TBUT improved by 0.805 seconds from baseline to month 6. In the supplement/cyclosporine group, TBUT improved by 1.007 seconds from baseline. There was no statistically significant difference in TBUT between the two groups at baseline, month 3, or month 6. There were no significant differences in corneal or conjunctival staining between or within groups. Subjective symptoms were also improved in both groups.ConclusionSupplementation with the proper balance of omega-3 and omega-6 essential fatty acids improved TBUT and relieved patient symptoms. The addition of topical cyclosporine did not convey any statistically significant improvement in TBUT beyond that achieved by the supplement.

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Uso oral do óleo de linhaça (Linum usitatissimum) no tratamento do olhoseco de pacientesportadores da síndrome de Sjögren

Cited by 23 publications

References 29 publications

Comparação entre dois protocolos de tratamento de ceratoconjuntivite seca experimentalmente induzida em coelhos

Comparação entre dois protocolos de tratamento de ceratoconjuntivite seca experimentalmente induzida em coelhos

Objective assessment of conjunctival squamous metaplasia by measures of cell and nucleus dimensions

Efficacy of a new prescription-only medical food supplement in alleviating signs and symptoms of dry eye, with or without concomitant cyclosporine A

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