Introduction: When an individual is affected by laryngeal cancer and the treatment chosen is total laryngectomy, the aspect that will present the greatest modification is phonation, since the laryngeal voice will no longer be possible and rehabilitation with a new method of communication is necessary to re-establish this function. Among the methods of choice is the speech esophageal (SE), which shows variability of success. Understanding how these modifications may impact the quality of life and which protocols are the most appropriate for this population may favor the chances of therapeutic success and help in the reintegration of this individual in the social and family environment. Objective: To compare different quality of life protocols in total laryngectomized speakers and non-speaking patients through speech esophageal. Methods: This is an observational cross-sectional study with 38 total laryngectomized people with speech esophageal, classified 19 in the group of speakers and 19 non-speaking. The VAS scale and the VHI, V-RQOL, FACT-H & N, EORTC QLQ-C30, EORTC QLQ-H & N35 and UW-QOL protocols were applied. Results: It was observed that total laryngectomies rehabilitated with speech esophageal, achieved better scores with statistical difference in the functional domain for the speaking group. There was a strong inversely proportional correlation in the group of speakers, non-speakers and total sample with QOL and VHI. There was a strong-moderate correlation with the EORTC QLQ-C30 functional scale and all other protocols in both groups. The correlation between the EORTC QLQ-H & N35 with the UW-QOL was moderate in the group speakers and strong in the nonspeaking group. UW-QOL also showed moderate to strong correlations with VHI and EORTC QLQ-C30 in both groups. Conclusion: The EORTC QLQ-C30 protocol, with its specific EORTC QLQ-H & N35, and UW-QOL were the ones that most correlated with the other protocols, being able to be used by anyone who wants to evaluate the quality of life of this population.