Introduction: At present, National Healthcare and Demography Projects are being implemented in the Russian Federation and in the Orenburg Region, including the Regional Project for Prevention of Cardiovascular Diseases. Within the National Healthcare Project, the task has been set to reduce the mortality rate from diseases of the circulatory system to 450 per 100,000 population by the year 2024 (from 573.6 per 100,000 population registered in 2018). The regional goal is 477 per 100,000 population in 2024 (against 635.5 per 100,000 population in the year 2018). However, practical implementation of the project shows that in 2019–2020, the targets were not achieved. It is, therefore, important to monitor this indicator and to assess preventable losses associated with diseases of the circulatory system by all possible means including with the use of information technologies. Our objective was to establish regional features of the structure, dynamics, and rates of diseases of the circulatory system among the population of the region and to determine municipalities with high rates of cardiovascular disorders. Materials and methods: We used data of the Russian statistical collections “Medical and Demographic Indicators”, “Morbidity of the Population of Russia”, and annual information and analytical collections of the Orenburg Medical Information and Analytical Center for the years 2009–2018 to conduct a time series analysis. Results: We observed an increase in the incidence rate of diseases of the circulatory system in the population of the Orenburg Region over the ten-year period. The maximum regional rate of 67.0 ± 1.8 per 1,000 population was registered in 2018 while the minimum rate was observed in 2009 and equaled 27.0 ± 0.27 per 1,000 population. Conclusion: The study period was characterized by an increase in the incidence of diseases of the circulatory system accompanied by a statistically significant decrease in the prevalence of cardiovascular diseases in the adult population of the Orenburg Region. The diseases related to high blood pressure ranked first.