Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue

Yue, Xiaojie; Hu, Hanguang; Koetsier, M.; Graaff, Reindert; Han, Chunmao

doi:10.1111/j.1464-5491.2010.03217.x

Cited by 47 publications

(65 citation statements)

References 18 publications

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“…The linear association between increasing chronological age and skin autofluorescence was previously reported in healthy individuals 34,35 and other CKD cohorts. 6,13 However, our study did not observe any significant relations between individual biochemical parameters of CKDmineral bone disease, including serum calcium, phosphate, and alkaline phosphatase with vascular calcification.…”

Section: Discussionmentioning

confidence: 74%

Skin Autofluorescence Associates With Vascular Calcification in Chronic Kidney Disease

Wang

Wong

Yau

et al. 2014

ATVB

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Objective— This study aims to evaluate the relationship between tissue advanced glycation end products, as reflected by skin autofluorescence, and vascular calcification in chronic kidney disease. Approach and Results— Three hundred patients with stage 3 to 5 chronic kidney disease underwent multislice computed tomography to estimate total coronary artery calcium score (CACS) and had tissue advanced glycation end product assessed using a skin autofluorescence reader. Intact parathyroid hormone ( P <0.001) displaced estimated glomerular filtration rate as third most significant factor associated with skin autofluorescence after age ( P <0.001) and diabetes mellitus ( P <0.001) in multiple regression analysis. On univariate multinomial logistic regression analysis, every 1-U increase in skin autofluorescence was associated with a 7.43-fold (95% confidence intervals, 3.59–15.37; P <0.001) increased odds of having CACS ≥400 compared with those with zero CACS. Skin autofluorescence retained significance in predicting CACS ≥400 (odds ratio, 3.63; 95% confidence intervals, 1.44–9.18; P =0.006) when adjusting for age, sex, serum calcium, phosphate, albumin, C-reactive protein, lipids, blood pressure, estimated glomerular filtration rate, and intact parathyroid hormone but marginally lost significance when additionally adjusting for diabetes mellitus (odds ratio, 2.23; 95% confidence intervals, 0.81–6.14; P =0.1). Combination of diabetes mellitus and higher intact parathyroid hormone was associated with greater skin autofluorescence and CACS versus those without diabetes mellitus and having lower intact parathyroid hormone. Conclusions— Tissue advanced glycation end product, as reflected by skin autofluorescence, showed a significant novel association with vascular calcification in chronic kidney disease. These data suggest that increased tissue advanced glycation end product may contribute to vascular calcification in chronic kidney disease and diabetes mellitus and warrant further experimental investigation.

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Section: Discussionmentioning

confidence: 74%

Skin Autofluorescence Associates With Vascular Calcification in Chronic Kidney Disease

Wang

Wong

Yau

et al. 2014

ATVB

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“…With regard to gender difference, our current study and some previous studies showed higher levels of skin autofluorescence in men. However, other studies did not show gender difference [29] or even showed higher levels of AGEs in women [30,31]. In addition to inadequate power because of small sample size, several other factors might play a role.…”

Section: Discussionmentioning

confidence: 89%

“…Chinese men usually have darker color than Chinese women. In a Chinese methodological study, the frequency of measurement failures was higher in men than women (21.5 vs. 11.0%, p < 0.01) [29]. …”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness

Liu

Huang

Cheng

et al. 2016

Pulse

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Background: We compared skin and plasma measurements of advanced glycation end products (AGEs), with particular focus on their levels in the presence of hypertension or diabetes and prediabetes and their associations with arterial stiffness in outpatients with suspected or diagnosed hypertension. Methods: Skin AGE accumulation was measured as autofluorescence on the left forearm using the skin autofluorescence Reader and expressed in arbitrary units in the range from 0 to 25. Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor system (Sydney, Australia). Results: The 218 participants (96 [44.0%] men, mean age 51.9 years) had a mean skin autofluorescence of 1.89 arbitrary units, plasma AGE concentration of 4.47 μg/ml, and cfPWV of 8.0 m/s. Skin autofluorescence was significantly correlated with plasma AGEs in diabetic or prediabetic patients (n = 31, r = 0.37, p = 0.04) but not in subjects with normoglycemia (n = 187, r = -0.05, p = 0.48). Nonetheless, both measurements were significantly (p ≤ 0.001) higher in men (2.00 arbitrary units and 6.73 μg/ml, respectively) than women (1.81 arbitrary units and 3.60 μg/ml, respectively) and in diabetic or prediabetic (2.03 arbitrary units and 6.61 μg/ml, respectively) than normoglycemia subjects (1.87 arbitrary units and 4.17 μg/ml, respectively), but similar in hypertensive (n = 105) and normotensive subjects (n = 113, p ≥ 0.35). In adjusted multiple regression analyses, plasma AGE concentration, but not skin autofluorescence (p ≥ 0.37), was significantly associated with cfPWV in all subjects (β 0.44 m/s for each 10-fold increase; p = 0.04) and in subgroups of men and diabetes and prediabetes (β 0.12-0.55 m/s for each 10-fold increase; p ≤ 0.02). Conclusions: Although skin and plasma AGEs were similarly associated with gender and diabetes or prediabetes, they might measure something different and have different clinical relevance, such as for arterial stiffness.

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“…The value of AF was strongly related to age, but no significant difference between males and females was found. AF was lower in non-smokers than in smokers [11]. In persons with low skin reflectance (<10%), skin AF was dependent on skin colour, but was still related to age [12,13].…”

Section: Discussionmentioning

confidence: 99%

Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

Dina

Vladu

Dina

et al. 2012

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue

Cited by 47 publications

References 18 publications

Skin Autofluorescence Associates With Vascular Calcification in Chronic Kidney Disease

Skin Autofluorescence Associates With Vascular Calcification in Chronic Kidney Disease

A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness

Advanced Glycation End Products Measured by Age Reader in a Group of Patients with Obesity

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