Reduced total antioxidant level and increased oxidative stress in patients with deficit schizophrenia: A preliminary study

Albayrak, Yakup; Ünsal, Cüneyt; Beyazyüz, Murat; Ünal, Ahmet; Kuloğlu, Murat

doi:10.1016/j.pnpbp.2013.04.020

Cited by 41 publications

(30 citation statements)

References 65 publications

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“…The present study also supports that hypothesis. Although there are different results derived from previous studies, it is generally expressed that antioxidants are reduced in schizophrenia [8,24,35,40,42,43,[45][46][47]. In the present study, significantly lower plasma TAL levels were found in patients with schizophrenia compared to the controls.…”

Section: Discussioncontrasting

confidence: 81%

“…Increased oxidative stress is common in schizophrenia and in vivo mechanisms are insufficient to neutralize this condition. OSI levels are reported to be increased in schizophrenia [25,31,46,47,57,58]. May it be oxidative stress and increased OSI or insufficient antioxidant response, and the resulting disruption in the equilibrium between these mechanisms ultimately could cause breakdown of cellular elements and functional compounds [59].…”

Section: Discussionmentioning

confidence: 99%

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Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated.Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p < .05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p = .01, p = .01, respectively), Positive and Negative Syndrome ScaleNegative scores (p = .002, p = .001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p = .03, p = .03, respectively), and Clinical Global ImpressionSeverity Scale scores (p = .008, p = .009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p = .032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.ARTICLE HISTORY

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

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“…Because of the additive effects of different antioxidant components, only TAS levels can show the antioxidant status of the plasma [15]. There are many studies which evaluated TOS and TAS levels in schizophrenia and a few studies in bipolar disorder [16,17], whereas there is only one study about schizoaffective disorder [18]. In this sole study which had investigated oxidative stress parameters, TOS levels were found to be higher in schizoaffective disorder patients than both schizophrenia and bipolar disorder patients.…”

Section: Introductionmentioning

confidence: 78%

Oxidative parameters, oxidative DNA damage, and urotensin-II in schizoaffective disorder patients

Kılıç

Aksoy

Elboğa

et al. 2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: Complexity of schizoaffective disorder makes the identification of its pathophysiology a great challenge and there are very limited published data about the role of oxidative stress. Oxidative DNA damage has not been investigated in schizoaffective disorder. Therefore, we aimed to evaluate oxidative DNA damage together with oxidative stress and urotensin-II in patients with schizoaffective disorder. METHODS: Fifty-four patients who were diagnosed as schizoaffective disorder bipolar type (27 of them were in symptomatic remission and 27 of them were not) and 27 healthy volunteers were included in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), and urotensin-II (U-II) levels were calculated and evaluated. RESULTS: TAS and U-II levels were found to be lower in the patient group with and without remission when compared with the control group separately. There were no significant difference in terms of TOS, OSI, and 8-OHdG. Similar results were obtained when those in symptomatic remission and non-remission patient groups were combined and compared with the control group. CONCLUSION: TAS levels in schizoaffective disorder patients were lower than controls, which may mean a vulnerability to the oxidative stress but there were no differences in terms of oxidative DNA damage. U-II levels in schizoaffective disorder patients were significantly lower than controls in contrast with our previous study. ARTICLE HISTORY

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“…There are however indications that vitamin D could be more directly involved in the pathogenesis of specific symptoms. Vitamin D is considered neuroprotective properties through its prevention of oxidative stress in the central nerve system (Wrzosek et al, 2013) and there are hypothesis how oxidative stress may cause negative symptoms (Albayrak et al, 2013), possibly by imbalance in the excitative-inhibitory glutamate-GABA responses (Sullivan and O'Donnell, 2012) There are also indications that vitamin D is involved in the pathogenesis of depression, possible through the serotonin system, as vitamin D recently has been discovered as a regulator of the serotonin synthesis (Patrick and Ames, 2014). The observed seasonality in affective disorders also implicates an important role for sun exposure and vitamin D in depression (Akhter et al, 2013;Geoffroy et al, 2014).…”

Section: Discussionmentioning

confidence: 99%