Oxidative parameters, oxidative DNA damage, and urotensin-II in schizoaffective disorder patients

Abstract

OBJECTIVE: Complexity of schizoaffective disorder makes the identification of its pathophysiology a great challenge and there are very limited published data about the role of oxidative stress. Oxidative DNA damage has not been investigated in schizoaffective disorder. Therefore, we aimed to evaluate oxidative DNA damage together with oxidative stress and urotensin-II in patients with schizoaffective disorder. METHODS: Fifty-four patients who were diagnosed as schizoaffective disorder bipolar type (27 of them were in symptomatic remission and 27 of them were not) and 27 healthy volunteers were included in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), and urotensin-II (U-II) levels were calculated and evaluated. RESULTS: TAS and U-II levels were found to be lower in the patient group with and without remission when compared with the control group separately. There were no significant difference in terms of TOS, OSI, and 8-OHdG. Similar results were obtained when those in symptomatic remission and non-remission patient groups were combined and compared with the control group. CONCLUSION: TAS levels in schizoaffective disorder patients were lower than controls, which may mean a vulnerability to the oxidative stress but there were no differences in terms of oxidative DNA damage. U-II levels in schizoaffective disorder patients were significantly lower than controls in contrast with our previous study. ARTICLE HISTORY

Antipsychotic Drug Aripiprazole Protects Liver Cells from Oxidative Stress

“…There was no upregulation of DNA damage response and endoplasmic and mitochondrial UPR in the tested conditions. This is in agreement with the reports of no increased oxidative DNA damage in schizophrenia [ 9 , 38 ]. UPR induction in the endoplasmic reticulum of liver cells was reported after a single aripiprazole treatment at about 10 times higher concentrations [ 39 ].…”

“…The results may differ because of interindividual variability, different populations, i.e., drug-naive and medicated patients, different antipsychotics used and assessment in different tissues. Reports of lower antioxidant capacity and lower antioxidant levels in schizophrenia patients’ plasma are consistent [ 38 , 41 , 42 , 43 ], as well as those of weaker antioxidant defenses in their cerebrospinal fluid [ 9 ]. It would be interesting to see whether ARI has a similar antioxidative effect in other tissues as we report here in liver cells.…”

Association of Oxidative Stress–Induced Nucleic Acid Damage With Psychiatric Disorders in Adults

“…Details of the search results are presented in eFigure 1 in the Supplement. We identified 82 studies fulfilling the inclusion criteria, comprising 205 patient vs control group comparisons and a total of 10 151 patient and 10 532 control observations. Seven studies had interventions, comprising a total of 15 preintervention-postintervention comparisons.…”