Recovery from optic neuritis attack in neuromyelitis optica spectrum disorder and multiple sclerosis

Masuda, Hiroki; Mori, Masahiro; Uzawa, Akiyuki; Muto, Mayumi; Uchida, Tatsuo; Ohtani, Ryohei; Akiba, Ryutaro; Yokouchi, Hirotaka; Yamamoto, Shuichi; Kuwabara, Satoshi

doi:10.1016/j.jns.2016.06.036

Cited by 18 publications

(10 citation statements)

References 9 publications

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“…Similar to previous studies, 16 , 17 we found worse VA in acute ON attacks in ON-NMOSD than those found in ON-MS with 79.2% of the ON-NMOSD group having VA ≥1 logMAR. Concordant with one previous study, 18 we found poorer visual recovery in nearly one-half of the patients with ON-NMOSD who still had a VA of logMAR ≥1 at the last follow-up visit.…”

Section: Discussionsupporting

confidence: 91%

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Srikajon

Siritho

Ngamsombat

et al. 2018

Multiple Sclerosis Journal - Experimental, Translational and Cl

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BackgroundOptic neuritis (ON) is one of the common manifestations both in neuromyelitis-optica spectrum disorders (NMOSD) and in multiple sclerosis (MS).ObjectivesThe objective of this paper is to compare clinical presentations, laboratories and imaging findings in ON associated with MS and NMOSD.MethodsA retrospective chart review was performed in patients presenting with ON in 59 NMOSD patients with 72 eyes’ involvement and 163 ON attacks, and 20 MS patients with 23 eyes’ involvement and 36 ON attacks.ResultsON-NMOSD patients had recurrent ON more often and tended to have simultaneous bilateral ON involvement at their first ON attack. Individuals with ON-NMOSD revealed worse visual acuity at first ON attacks and also had poorer long-term visual outcome than those with ON-MS, with nearly half of ON-NMOSD patients still having LogMAR visual acuity ≥1 at their last follow-up (p = 0.035). Significant thinner average retinal nerve fiber layer thickness was found in the ON-NMOSD group. We found no significant differences in segmentation location of the optic nerve lesions and the length of involvement between the two groups.ConclusionsIt was difficult to completely differentiate ON-NMOSD from ON-MS. ON-NMOSD patients, however, tended to have simultaneous bilateral ON involvement and poorer long-term visual outcome than individuals with ON-MS.

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Section: Discussionsupporting

confidence: 91%

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Srikajon

Siritho

Ngamsombat

et al. 2018

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…Our univariate analysis showed a beneficial effect of steroid treatment on recovery. Previous studies have shown either a lack of effect, 25 or an inconsistent improvement. 24 …”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have shown either a lack of effect, 25 or an inconsistent improvement. 24 The observed decline in recovery with increased age at onset has been shown previously in CLIMB 26 and other cohorts, 3,9,24 whereas two studies in Italian cohorts found no age effect.…”

Section: Discussionmentioning

confidence: 94%

Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability

Sotiropoulos

Lokhande

Healy

et al. 2021

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Although recovery from relapses in MS appears to contribute to disability, it has largely been ignored as a treatment endpoint and disability predictor. Objective To identify demographic and clinical predictors of relapse recovery in the first 3 years and examine its contribution to 10-year disability and MRI outcomes. Methods Relapse recovery was retrospectively assessed in 360 patients with MS using the return of the Expanded Disability Status Scale (EDSS), Functional System Scale and neurologic signs to baseline at least 6 months after onset. Univariate and multivariable models were used to associate recovery with demographic and clinical factors and predict 10-year outcomes. Results Recovery from relapses in the first 3 years was better in patients who were younger, on disease-modifying treatment, with a longer disease duration and without bowel or bladder symptoms. For every incomplete recovery, 10-year EDSS increased by 0.6 and 10-year timed 25-foot walk increased by 0.5 s. These outcomes were also higher with older age and higher baseline BMI. Ten-year MRI brain atrophy was associated only with older age, and MRI lesion volume was only associated with smoking. Conclusions Early initiation of disease-modifying treatment in MS was associated with improved relapse recovery, which in turn prevented long-term disability.

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“…12 Furthermore, recent studies have shown that the final visual acuity is significantly worse in pwNMOSD compared to pwMS. 11,13 Further emphasizing the importance of this difference is a study that showed vision-related quality of life to be reduced in pwNMOSD compared to pwMS patients, and this difference is driven by more severe ON in pwNMOSD. 14 As COMPASS-31 evaluates autonomic symptom burden and is one of the patient-related measures of autonomic dysfunction, including problems with the vision, our finding supports the influence of visual symptoms on pwNMOSD.…”

Section: Discussionmentioning

confidence: 99%

Autonomic dysfunction in people with neuromyelitis optica spectrum disorders

et al. 2019

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Aims: To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS). Design/Methods: Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. The quantification of cardiovascular autonomic dysfunction (CAD) was made using the two indices of the Composite Autonomic Scoring Scale (CASS): adrenergic index (AI) and cardiovagal index (CI). Results: In all pwNMOSD, COMPASS-31 was >0. Sympathetic dysfunction was present in 8 (40%), parasympathetic dysfunction in 10 (50%), and orthostatic hypotension in 6 (30%) pwNMOSD. This group of patients had higher frequency and level on the pupillomotor domain of the COMPASS-31 compared to pwMS ( p = 0.048 and p = 0.006, respectively). A binary logistic regression model showed that drop in diastolic blood pressure (dBP) during tilt-table test and normal function of autonomic nervous system, defined as AI = 0 and CI = 0, were independent predictors of pwNMOSD ( p = 0.042 and p = 0.029, respectively). If CAD was present, it was significantly worse in pwNMOSD compared to pwMS ( p = 0.003). Conclusion: Significant proportion of pwNMOSD experience dysautonomia, which seems to be different from dysautonomia observed in pwMS.

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Recovery from optic neuritis attack in neuromyelitis optica spectrum disorder and multiple sclerosis

Cited by 18 publications

References 9 publications

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability

Autonomic dysfunction in people with neuromyelitis optica spectrum disorders

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