Recent progresses in biomedical applications of aptamer-functionalized systems

Ding, Fei; Gao, Yangguang; He, Xu

doi:10.1016/j.bmcl.2017.03.032

Cited by 31 publications

(12 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are obtained using the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) system. The fact that aptamers are produced without need for animal experimentation, their smaller size compared with antibodies, and their easier modification, are some of the advantages that have made them a promising tool in the biomedical field, mainly for biosensing or for targeting molecules for therapy, imaging, and drug delivery [109,110].…”

Section: Organic Nanosystemsmentioning

confidence: 99%

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2019

View full text Add to dashboard Cite

Recently, antimicrobial peptides (AMPs), also called host defence peptides (HDPs), are attracting great interest, as they are a highly viable alternative in the search of new approaches to the resistance presented by bacteria against antibiotics in infectious diseases. However, due to their nature, they present a series of disadvantages such as low bioavailability, easy degradability by proteases, or low solubility, among others, which limits their use as antimicrobial agents. For all these reasons, the use of vehicles for the delivery of AMPs, such as polymers, nanoparticles, micelles, carbon nanotubes, dendrimers, and other types of systems, allows the use of AMPs as a real alternative to treatment with antibiotics.

show abstract

Section: Organic Nanosystemsmentioning

confidence: 99%

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Many systems incorporating both aptamers and pH responsive elements have been developed for the targeted delivery of anti-cancer drugs [ 7 , 13 , 14 ]. Often, chemotherapeutics cause off-target toxicity; directed delivery can increase the effectiveness of the drugs and reduce adverse effects [ 14 ].…”

Section: Combination Of Aptamers With Ph-responsive Systems For Drmentioning

confidence: 99%

“…These include ease of chemical modification, improved stability over time and at variable pH or temperature, reversible conformation change in response to stimulus, and quick and reliable synthesis in vitro [ 5 , 6 ]. Because of these properties, much work has been done on expanding the applications of aptamers and combining them with other functional elements [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

pH-Control in Aptamer-Based Diagnostics, Therapeutics, and Analytical Applications

Belleperche

DeRosa

2018

Pharmaceuticals

View full text Add to dashboard Cite

Aptamer binding has been used effectively for diagnostics, in-vivo targeting of therapeutics, and the construction and control of nanomachines. Nanostructures that respond to pH by releasing or changing affinity to a target have also been used for in vivo delivery, and in the construction of sensors and re-usable nanomachines. There are many applications that use aptamers together with pH-responsive materials, notably the targeted delivery of chemotherapeutics. However, the number of reported applications that directly use pH to control aptamer binding is small. In this review, we first discuss the use of aptamers with pH-responsive nanostructures for chemotherapeutic and other applications. We then discuss applications that use pH to denature or otherwise disrupt the binding of aptamers. Finally, we discuss motifs using non-canonical nucleic acid base pairing that can shift conformation in response to pH, followed by an overview of engineered pH-controlled aptamers designed using those motifs.

show abstract

“…6 The concept of a "magic bullet" has inspired practitioners to use aptamers to construct smart devices. 7 For instance, a nucleolin-targeted intelligent DNA nanorobot that utilized an aptamer and DNA origami was constructed to obstruct vasculature feeding for cancer therapy. 8 Hao et al developed aptamer-functionalized microfluidic devices based on dendrimers for sensitive and rapid detection of foodborne pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

View full text Add to dashboard Cite

Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.

show abstract

Recent progresses in biomedical applications of aptamer-functionalized systems

Cited by 31 publications

References 90 publications

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

pH-Control in Aptamer-Based Diagnostics, Therapeutics, and Analytical Applications

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Contact Info

Product

Resources

About