Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Martín-Serrano, Ángela; Gómez, Rafael; Ortega, Paula; Mata, F. Javier de la

doi:10.3390/pharmaceutics11090448

Cited by 97 publications

(76 citation statements)

References 120 publications

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“…Furthermore, organic nanosystems such as liposomes, lipid-based nanoparticles, polymeric micelles and polymeric nanoparticles have preferable biodegradability and biocompatibility features, making them suitable candidates for clinical use [27]. Herein, we will report on the recent updates of organic and inorganic nanosystems as antibacterial drug delivery systems with a brief description of each system.…”

Section: Classification Of Nanosystemsmentioning

confidence: 99%

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Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.

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Section: Classification Of Nanosystemsmentioning

confidence: 99%

“…In general, metal nanoparticles have some advantages, such as large surface area and multimodal applications. However, toxicity, instability, and storage are major drawbacks of inorganic nanosystems [27].…”

Section: Advantages and Drawbacks Of Inorganic Nanoparticlesmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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“…Several approaches to protect peptides from enzymatic degradation have been proposed. The most used one is the loading of peptides in nanosystems such as nanoparticles, liposomes, or self-emulsifying drug delivery systems [27][28][29]. However, the realization of these nanosystems is very complicated, and their industrial application may be limited by high production costs.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Peptide Affinity and Stability by Complexing to Cyclodextrin-Grafted Ammonium Chitosan

et al. 2020

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Cyclodextrin-grafted polymers are attractive biomaterials that could bring together the host–guest complexing capability of pristine cyclodextrin and the pharmaceutical features of the polymeric backbone. The present paper is aimed at characterizing the potential application of ammonium–chitosan grafted with 2-methyl-β-cyclodextrin (N+-rCh-MCD) as the functional macromolecular complexing agent for the oral administration of the neuropeptide dalargin (DAL). Specific NMR characterization procedures, along with UV and fluorescence techniques, as well as biological in vitro assessments have been performed. The results indicate that N+-rCh-MCD forms water-soluble complexes with DAL, with a prevalent involvement of Tyr or Phe over Leu and Ala residues. The association constant of DAL with the polymeric derivative is one order of magnitude higher than that with the pristine cyclodextrin (Ka: 2600 M−1 and 120 M−1, respectively). Additionally, N+-rCh-MCD shields DAL from enzymatic degradation in gastrointestinal in vitro models with a three-fold time delay, suggesting a future pharmaceutical exploitation of the polymeric derivative. Therefore, the greater affinity of N+-rCh-MCD for DAL and its protective effect against enzymatic hydrolysis can be attributed to the synergistic cooperation between cyclodextrin and the polymer, which is realized only when the former is covalently linked to the latter.

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“…Polyvinyl alcohol (PVA) hydrogels have been deeply explored due to their excellent biocompatibility properties and have been FDA (Food and Drug Administration) approved [ 12 ]. Hydrogels have received growing attention as drug delivery systems over the last decade due to their exclusive properties, such as high biocompatibility, tunable release rate, and versatility to be loaded with different molecules [ 13 , 14 ]. The most relevant characteristics of hydrogels are their porosity, pore size, and physicochemical environment of the matrix, which is tunable by modifying the crosslink density and/or varying the crosslinker type in their network.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

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A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

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Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Cited by 97 publications

References 120 publications

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Improvement of Peptide Affinity and Stability by Complexing to Cyclodextrin-Grafted Ammonium Chitosan

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

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