Recent Progress of Marine Polypeptides as Anticancer Agents

Zheng, Lanhong; Xu, Yixin; Lin, Xiukun; Yuan, Zhi-Xin; Liu, Minghua; Cao, Shousong; Zhang, Fuming; Linhardt, Robert J.

doi:10.2174/1574892813666180430110033

Cited by 15 publications

(6 citation statements)

References 78 publications

(90 reference statements)

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“…The special marine environment provides a diversity of marine natural products, providing unique anticancer peptides with more promising clinical value than other sources of anticancer. 58 Five AMPs were extracted from snow crab by Doiron and others. These peptides can effectively reduce biological fouling and are of great help to the problem of corrosion caused by microorganisms on the submerged surface.…”

Section: Marine Biopeptidesmentioning

confidence: 99%

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Recent research progress of biologically active peptides

et al. 2022

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With the rapid development of molecular biology and biochemical technology, great progress has been made in the study of peptides. Peptides are easy to digest and absorb, with lowering of blood pressure and cholesterol, improving immunity, regulating hormones, antibacterial, and antiviral effects. Peptides also have physiological regulation and biological metabolism functions with applications in the fields of feed production and biomedical research. In the future, the research focus of bioactive peptides will focus on their efficient preparation and application. This article introduces a comprehensive review of the types, synthesis, functionalization, and bio‐related applications of bioactive peptides. For this aim, we introduced in detail various biopeptides and then presented the production methods of bioactive peptides, such as enzymatic synthesis, microbial fermentation, chemical synthesis, and others. The applications of bioactive peptides for anticancers, immune therapy, antibacterial, and other applications have been introduced and discussed. And discussed the development prospects of biologically active peptides.

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Section: Marine Biopeptidesmentioning

confidence: 99%

“…Because of the special life of these organisms in the oceans, some of these compounds can only be found from a single source. The special marine environment provides a diversity of marine natural products, providing unique anticancer peptides with more promising clinical value than other sources of anticancer 58 …”

Section: Classification Of Bioactive Peptidesmentioning

confidence: 99%

Recent research progress of biologically active peptides

et al. 2022

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“…Marine peptides are rich in hydroxy acids, thiophenols, and D- and α -amino acids. Some components possess ethylenic bonds and acetylenic bonds, which improve the stability and bioavailability of peptides [ 16 , 17 , 18 , 19 , 20 , 21 ]. Compared with traditional small molecule inhibitors, marine peptides present high activity, strong targeting, low toxicity, easy transmembrane absorption, and own a wide range of biological activities, such as antitumor, anti-inflammatory, antivirus, and antiinfection.…”

Section: Introductionmentioning

confidence: 99%

“…However, the rare content in organisms brings great obstacles to the enrichment and further biological evaluation of bioactive peptides. Because of the relatively simple chemical structure, scientists prepared a large amount of Dol-10 by chemical synthesis, which laid the foundation for its further development and clinical evaluation [ 16 , 21 , 42 ]. Due to its adverse effects, such as the most common peripheral neuropathy, Dol-10 was stagnated in phase II clinical trial [ 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry

et al. 2021

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Dolastatin 10 (Dol-10), a leading marine pentapeptide isolated from the Indian Ocean mollusk Dolabella auricularia, contains three unique amino acid residues. Dol-10 can effectively induce apoptosis of lung cancer cells and other tumor cells at nanomolar concentration, and it has been developed into commercial drugs for treating some specific lymphomas, so it has received wide attention in recent years. In vitro experiments showed that Dol-10 and its derivatives were highly lethal to common tumor cells, such as L1210 leukemia cells (IC50 = 0.03 nM), small cell lung cancer NCI-H69 cells (IC50 = 0.059 nM), and human prostate cancer DU-145 cells (IC50 = 0.5 nM), etc. With the rise of antibody-drug conjugates (ADCs), milestone progress was made in clinical research based on Dol-10. A variety of ADCs constructed by combining MMAE or MMAF (Dol-10 derivatives) with a specific antibody not only ensured the antitumor activity of the drugs themself but also improved their tumor targeting and reduced the systemic toxicity. They are currently undergoing clinical trials or have been approved for marketing, such as Adcetris®, which had been approved for the treatment of anaplastic large T-cell systemic malignant lymphoma and Hodgkin lymphoma. Dol-10, as one of the most medically valuable natural compounds discovered up to now, has brought unprecedented hope for tumor treatment. It is particularly noteworthy that, by modifying the chemical structure of Dol-10 and combining with the application of ADCs technology, Dol-10 as a new drug candidate still has great potential for development. In this review, the biological activity and chemical work of Dol-10 in the advance of antitumor drugs in the last 35 years will be summarized, which will provide the support for pharmaceutical researchers interested in leading exploration of antitumor marine peptides.

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“…[3] Consequently, plentiful bioactive compounds with unique chemical structures are produced by various marine organisms. [4] These compounds have revealed promising biological potential, including antitumor, [5] anti-inflammatory, [6] antibacterial, [7] and antiviral activities. [8] Interestingly, some anticancer, antiviral and anti-hypertriglyceridemia drugs consumed in the market are of marine origin.…”

Section: Introductionmentioning

confidence: 99%

Recent Updates on Corals from Nephtheidae

Abdelhafez

Fahim

Desoukey

et al. 2019

Chemistry & Biodiversity

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Marine natural products display a wide range of biological activities, which play a vital role in the innovation of lead compounds for the drug development. Soft corals have been ranked at the top in regard to the discovery of bioactive metabolites with potential pharmaceutical applications. Many of the isolated cembranoids revealed diverse biological activities, such as anticancer, antidiabetic and anti‐osteoporosis. Likewise, sterols from soft corals exhibited interesting biological potential as anti‐inflammatory, antituberculosis and anticancer. Consequently, investigating marine soft corals will definitely lead to the discovery of a large number of chemically varied secondary metabolites with countless bioactivities for possible applications in medicine and pharmaceutical industry. This review provides a complete survey of all metabolites isolated from the family Nephtheidae, from 2011 until November 2018, along with their natural sources and biological potential whenever possible.

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Recent Progress of Marine Polypeptides as Anticancer Agents

Abstract: Marine peptides possess chemical diversity and display potent anticancer activity via targeting different signal pathways. Some of the marine peptides are promising to be developed as novel anticancer agents.

Cited by 15 publications

References 78 publications

Recent research progress of biologically active peptides

Recent research progress of biologically active peptides

Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry

Recent Updates on Corals from Nephtheidae

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