Recent research progress of biologically active peptides

Abstract

With the rapid development of molecular biology and biochemical technology, great progress has been made in the study of peptides. Peptides are easy to digest and absorb, with lowering of blood pressure and cholesterol, improving immunity, regulating hormones, antibacterial, and antiviral effects. Peptides also have physiological regulation and biological metabolism functions with applications in the fields of feed production and biomedical research. In the future, the research focus of bioactive peptides will focus on their efficient preparation and application. This article introduces a comprehensive review of the types, synthesis, functionalization, and bio‐related applications of bioactive peptides. For this aim, we introduced in detail various biopeptides and then presented the production methods of bioactive peptides, such as enzymatic synthesis, microbial fermentation, chemical synthesis, and others. The applications of bioactive peptides for anticancers, immune therapy, antibacterial, and other applications have been introduced and discussed. And discussed the development prospects of biologically active peptides.

Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing

“…Antimicrobial peptides usually have a positive charge and amphiphilic structure, 13 which can interact strongly with hydrophobic surfaces and membranes, and have strong spectral activity against bacteria, fungi, viruses, and other microorganisms. AMPs bind to microbial cell membranes through physical and chemical effects, accumulate on the surface of cell membranes, and undergo structural or conformational changes.…”

Screening and investigation of a short antimicrobial peptide: AVGAV

“…Red blood cells were treated using different samples, and the supernatant was collected after centrifugal treatment. The absorbance of the supernatant at a wavelength of 570 nm was detected, and the hemolysis rate was calculated using eqn (2), where A 0 was the absorbance of the sample, and A n and A P represented the absorbance of the negative control group and the positive control group, respectively.…”

“…The increase in bacterial resistance caused by the overuse of antibiotics is a major problem affecting the field of antimicrobial agents. 1 Antimicrobial peptides with good biocompatibility and long-lasting antibacterial properties 2 are emerging as new antibacterial drugs and are expected to replace conventional antibiotics. 1,3 Antimicrobial peptides (AMPs), widely existing in nature, have a broad spectrum of killing effects on Gram-negative and Gram-positive bacteria.…”

Preparation and Properties of Self-Assembling Polypeptide Hydrogels and Their Application in Biomedicine

“…In the process of treating wounds, wound healing, the most challenging problem is to prevent infections caused by microbial invasion, especially in burns and chronic wounds, which lead to slow wound healing and increased. − To address such problems, peptide-based antimicrobial materials have been developed into effective weapons to fight off bacterial infections. , In addition, the resistance of bacteria to antimicrobial peptides (AMPs) is low or almost nonexistent, which favors aseptic treatment of wound . Currently, self-assembling materials based on antimicrobial peptides primarily utilize cationic properties, assembly structures, or the ability to carry antimicrobial agents to kill bacteria to prevent infections caused by bacteria and treat wounds. , Cationic self-assembling polypeptides rich in lysine and arginine have a polycationic surface and have antibacterial activity against broad-spectrum Gram-positive and Gram-negative .…”