Recent Updates on Corals from Nephtheidae

Abdelhafez, Omnia Hesham; Fahim, John Refaat; Desoukey, Samar Yehia; Kamel, Mohamed S.; Abdelmohsen, Usama Ramadan

doi:10.1002/cbdv.201800692

Cited by 21 publications

(29 citation statements)

References 58 publications

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“…Phylum Cnidaria contains over 11,000 species [31] and is one of the richest in secondary metabolites of various structure phyla [32]. These species remain an untapped source; however, a great variety of chemically unique structures with promising bioactive properties was described for this phylum until now [32].…”

Section: Cnidariamentioning

confidence: 99%

“…Soft corals (Alcyonacea) is an order of cnidarians belonging to class Anthozoa, subclass Octocorallia. They have proven to be rich sources of several groups of chemically different compounds with anti-inflammatory properties, with mechanisms of action that are reviewed in a number of reports [32,33]. Anti-inflammatory effects of compounds isolated from Taiwanese corals from 2008 until 2012 were fully described in review of Wei et al [33], where the authors presented all chemical structures of compounds and described their anti-inflammatory activities studied in different immune cells (neutrophils and macrophages) in vitro and in animal models of inflammation.…”

Section: Soft Coralsmentioning

confidence: 99%

“…Cis-5,8,11,14-eicosatetraenoic, being n-6 polyunsaturated fatty acid (PUFA), is considered a pro-inflammatory fatty acid, once it is a precursor of the synthesis of eicosanoids, increasing the inflammatory response [102]. On the other hand, long-chain n-3 PUFAs, such as cis-5,8,11,14,17-eicosapentaenoic (EPA) and cis-4,7,10,13,16,19-docosahexaenoic (DHA) acids, are known also to inhibit iNOS expression [103], decrease the production of inflammatory mediators (eicosanoids, cytokines and NO) [102], and shift M1/M2 macrophage balance towards the M2 phenotype [32]. Carotenoids identified in this work were shown earlier to influence the expression of the markers of inflammation and macrophage polarization.…”

Section: Molluscamentioning

confidence: 99%

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Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Долматова

Dolmatov

2020

Marine Drugs

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Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrophage balance is a promising current trend in pharmacology. Marine invertebrates are a vast source of the variety of structurally diverse compounds with potent pharmacological activities. For years, a large number of studies concerning the immunomodulatory properties of the marine substances have been run with using some intracellular markers of immune stimulation or suppression irrespective of the possible application of marine compounds in reprogramming of macrophage activation, and only few reports clearly demonstrated the macrophage-polarizing activities of some marine compounds during the last decade. In this review, the data on the immunomodulating effects of the extracts and pure compounds of a variety of chemical structure from species of different classes of marine invertebrates are described with focus on their potential in shifting M1/M2 macrophage balance towards M1 or M2 phenotype.

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Section: Cnidariamentioning

confidence: 99%

Section: Soft Coralsmentioning

confidence: 99%

Section: Molluscamentioning

confidence: 99%

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Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates

Долматова

Dolmatov

2020

Marine Drugs

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“…Yet no reports are available in the literature on the volatile composition of Malvaviscus plants except for that by Vazquez-Cahuich et al [16], where solely two compounds, namely eugenol and 1,4-dichlorobenzene, were detected at very low concentrations among the hydrodistilled leaf volatiles of M. arboreus growing in Mexico. Hence, in continuation of our research on M. arboreus plants cultivated in Egypt [12,14,[17][18][19], the present work was designed to identify and compare the volatile constituents of its leaves and flowers using the headspace GC-MS technique.…”

Section: Introductionmentioning

confidence: 99%

Headspace Volatiles of the Leaves and Flowers of Malvaviscus arboreus Cav. (Malvaceae)

Abdelhafez¹,

Fahim

Abdelmohsen

et al. 2021

J. Mex. Chem. Soc.

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Abstract. Malvaviscus arboreus Cav., commonly known as Sleeping Hibiscus, is a plant species that belongs to the family Malvaceae with ornamental, culinary, and ethnomedical importance. This medicinal herb was reported to exhibit noteworthy antioxidant, cytotoxic, hepatoprotective, and anti-infective activities attributed to the presence of a variety of phytochemicals. In this work, the volatile compositions of the leaves and flowers of M. arboreus were studied and compared for the first time using the headspace gas chromatography-mass spectrometry (GC–MS) technique. Overall, 39 components were identified, comprising 36 from the leaves and 11 from the flowers, with an evident greater contribution of oxygenated compounds (89.54% in leaves and 89.35% in flowers) to their total volatiles. Phenolic ethers (41.64%) and ketones (21.57%) were the major chemical groups emitted by the flowers, while ketones (27.40%) and carboxylic acids (18.16%) dominated the volatile blends of the leaves. Anethole (32.32%), methyl isobutenyl ketone (19.18%), and methyl chavicol (9.32%) were the most abundant floral volatiles, whereas acetic acid (18.16%) was the major constituent given off by the leaves, followed by 2-cyclohexenone (9.60%) and anethole (7.39%). Additionally, from a biosynthetic point of view, the floral volatiles of M. arboreus showed the prevalence of phenylpropanoids/benzenoids (41.64%); however, fatty acid derivatives (54.30%) predominated among those produced by the leaves. The obtained results revealed noteworthy qualitative and quantitative variations in M. arboreus leaves and flowers' headspace volatiles that would help complement our phytochemical knowledge on this limitedly studied plant. Resumen. Malvaviscus arboreus Cav., comúnmente conocida como “Sleeping Hibiscus”, es una especie vegetal que pertenece a la familia Malvaceae con importancia ornamental, culinaria y etnomédica. Se ha reportado que esta hierba medicinal exhibe actividades antioxidantes, citotóxicas, hepatoprotectoras y antiinfecciosas notables que se atribuyen a la presencia de una variedad de fitoquímicos. En este trabajo se estudiaron las composiciones volátiles de las hojas y flores de M. arboreus y fueron comparadas utilizando la técnica de cromatografía de gases-espectrometría de masas (GC-MS). En total, se identificaron 39 componentes comprendiendo 36 de las hojas y 11 de las flores, con un evidente mayor aporte de compuestos oxigenados (89,54% en hojas y 89,35% en flores). Los éteres fenólicos (41,64%) y cetonas (21,57%) fueron los principales grupos químicos emitidos por las flores, mientras que las cetonas (27,40%) y los ácidos carboxílicos (18,16%) dominaron las mezclas volátiles de las hojas. Anetol (32,32%), metil isobutenil cetona (19,18%) y metil chavicol (9,32%) fueron los volátiles florales más abundantes, mientras que el ácido acético (18,16%) fue el principal componente desprendido por las hojas, seguido de la 2-ciclohexenona. (9,60%) y el anetol (7,39%). Adicionalmente, desde el punto de vista biosintético, los volátiles florales de M. arboreus mostraron la prevalencia de fenil propanoides/benzenoides (41,64%); sin embargo, los derivados de ácidos grasos (54,30%) predominaron entre los producidos por las hojas. Los resultados obtenidos revelaron variaciones cualitativas y cuantitativas notables en los volátiles de las hojas y flores de M. arboreus que ayudarán a complementar nuestro conocimiento fitoquímico en esta planta estudiada hasta ahora de forma limitada.

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“…6,7 Among various marine invertebrates, so corals belonging to the family Nephtheidae have received attention as special providers of several chemical compounds with antifouling, antibacterial, antiviral, anti-diabetic, and anti-inammatory activities. [8][9][10] Likewise, a group of assorted metabolites with praiseworthy potential against human cancer cells has been described from various Nephtheidae species, 8,9,[11][12][13][14] which valorizes the promising exploration of these prolic organisms in the realm of nature-inspired anticancer drug discovery.…”

Section: Introductionmentioning

confidence: 99%