Recent progress in fluorescent and colorimetric chemosensors for detection ofamino acids

Abstract

Due to the biological importance of amino acids, the development of optical probes for these molecules has been an active research area in recent years. This tutorial review focuses on recent contributions since the year 2000 concerning the fluorescent or colorimetric sensors for amino acids, and is organized according to their structural classification and reaction types. For reaction based chemosensors, the works are classified according to the mechanisms between sensors and amino acids, including imine formation, Michael addition, thiazinane or thiazolidine formation, cleavage of a sulfonate ester, cleavage of disulfide, metal complexes-displace coordination and others.

A Highly Fluorescent Metallosalalen‐Based Chiral Cage for Enantioselective Recognition and Sensing

“…[14,18] Time-resolved fluorescence measurements of 1 after addition of the amine showed only a slight decrease in the decay rate, consistent with the above fluorescence-enhancing mechanism. We propose that the enantioselective enhancement is due to the formation of different diastereomeric host-guest complexes by selective adsorption.…”

Fluorescent/luminescent detection of natural amino acids by organometallic systems

“…A c c e p t e d M a n u s c r i p t Edited May 11 21 Recently, Chan and Leung et al also developed a coumarin-based ligand 38-Cu 2+ complex ( Figure 20) for the selective detection of His in a turn-on manner, which is applicable not only to aqueous solutions but also to living cells [70]. Upon adding His into the 38-Cu 2+ ensemble, His is capable of removing Cu 2+ from its ensemble by cooperative chelating action of the carboxyl and imidazole moieties of His.…”

A selective and sensitive fluorescent sensor for cysteine detection based on bi‐8‐carboxamidoquinoline derivative and Cu2+ complex

“…[19][20][21] Therefore, several fluorescent probes for Abbreviations used: DMF, dimethyl formamide; DMSO, dimethyl sulphoxide; ESI, electrospray ionization; FTIR, Fourier transform infra-red; NMR, nuclear magnetic resonance; PBS, phosphate-buffered saline; RSD, relative standard deviation the detection of Cys have been extensively investigated. [22] Various fluorescent probes for Cys, utilizing the strong nucleophilicity of Cys and their high binding affinity towards metal ions, have been reported. [23][24][25][26][27][28] Due to the strong affinity of Cys for metal ions, the addition of Cys into a fluorophore-metal ion complex system may release free fluorophores, and induce changes in the fluorescence intensity and/or colour of the system.…”