Fluorescent/luminescent detection of natural amino acids by organometallic systems

Wang, Jing; Liu, Hai-Bo; Tong, Zhangfa; Ha, Chang‐Sik

doi:10.1016/j.ccr.2015.05.008

Cited by 123 publications

(64 citation statements)

References 236 publications

(145 reference statements)

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“…Prior reviews have summarized biothiol fluorescent probes from different perspectives including bioimaging applications, [11] structure and reaction classification, [12] reaction types, [13] detection methods, and reaction mechanisms. [14] There have been a large number of fluorescent probes for biothiols reported in just the past decade. Most can be divided into three categories based on function: 1) The detection of GSH/Cys/Hcy (universal thiol probes) over other amino acids, [15] 2) the selective detection one or two of GSH/Cys/Hcy (Table 1), and 2) simultaneous discrimination of Cys, Hcy, and GSH.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

et al. 2017

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Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial roles in maintaining redox homeostasis in biological systems. This Minireview summarizes the most significant current challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under-investigated by chemists in the selective probe and sensor field. Progress on multiple binding site probes to distinguish Cys, Hcy, and GSH is highlighted as a creative new direction in the field that can enable simultaneous, accurate ratiometric monitoring. New probe design strategies and researcher priorities can better help address current challenges, including the monitoring of disease states such as autism and chronic diseases involving oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.

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Section: Introductionmentioning

confidence: 99%

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

et al. 2017

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“…Fluorescent materials, particularly blue fluorescent materials have gained strong interest because blue fluorescence is one of the key color components required for full-color EL displays and blue fluorescent materials are still rare up to now [1][2][3][4][5]. Recently, 4,4′-bipyridine (bipy) with delocalized -electrons of the pyridyl rings obtains increasing attention in preparing light emitting complexes in different technical applications, such as emitting materials for organic light emitting diodes, sensitizers in solar energy conversion, chemical sensors and so forth [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A novel samarium complex with interesting photoluminescence and semiconductive properties

Zhang¹,

Chen²,

F.Wang³

2018

Bull. Chem. Soc. Eth.

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ABSTRACT.[Sm(H2O)4(NO3)3](4,4'-Hbipy)2(NO3)2 (1) (bipy = bipyridine) has been synthesized via hydrothermal reaction and characterized by X-ray diffraction. The title complex features an isolated structure, based on discrete 4,4'-Hbipy moieties, isolated nitrates and [Sm(H2O)4(NO3)3] species. The samarium ion is in a distorted bicapped square antiprism environment, coordinated by three bidentate nitrates and four coordination water molecules. The 4,4'-Hbipy moieties, isolated nitrates and [Sm(H2O)4(NO3)3] species are held together via hydrogen bonds and … interactions to form a 3-D supramolecular framework. Luminescent investigation reveals a strong emission in blue region. Optical absorption spectrum of 1 reveals the presence of an optical gap of 3.60 eV.

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“…Metal complexes have the ability to mimic biological enzymes, they have been used as fluorescent sensors to sense biologically relevant small molecules, such as amino acids, saccharides and ribonucleosides . The effective sense of amino acids can be achieved by constructing a metal complex with special structure through reasonable design.…”

Section: Introductionmentioning

confidence: 99%

Chiral Zinc Complexes Used as Fluorescent Sensor for Natural Amino Acids

Zhao

Wang

et al. 2019

ChemistrySelect

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Metal complexes have been used as “enzyme mimics” to sense many biologically relevant molecules. Herein, a pair of chiral mononuclear zinc complexes have been used as biomimetic models to sense natural amino acids. These chiral zinc complexes were easy to prepare and the ligands were derived from the cheap and readily available natural chiral lactic acids. They exhibited the ability to distinguish Cys (cysteine) and His (histidine) from other natural amino acids at the same time in aqueous solution. Moreover, they also performed effectively enantioselective discrimination for enantiomers of Leu, Met, Val and Phe in acetonitrile.

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Fluorescent/luminescent detection of natural amino acids by organometallic systems

Cited by 123 publications

References 236 publications

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH

A novel samarium complex with interesting photoluminescence and semiconductive properties

Chiral Zinc Complexes Used as Fluorescent Sensor for Natural Amino Acids

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