Recent expansions in an emergent novel drug delivery technology: Emulgel

AJAZUDDIN, .; Alexander, Amit; Khichariya, Ajita; Gupta, Sumeet; Patel, Ravish J.; Giri, Tapan Kumar; Tripathi, Dulal Krishna

doi:10.1016/j.jconrel.2013.06.030

Cited by 177 publications

(112 citation statements)

References 77 publications

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“…In the development of biohybrid emulsions, it is important to analyze the rheology properties and, consequently, the delivery kinetics of the compound of interest, which would be modified [44]. In general, an increase in viscosity causes a decrease in the rate of drug delivery [45]; it also affects the structural excipients organization in the final pharmaceutical form [46]. Jacobs et al formulated emulsions modified of different concentrations of xanthan gum aiming at the delivery of acyclovir and ketoconazole for the treatment of epidermal fungal disorders [47].…”

Section: 1mentioning

confidence: 99%

“…Figure 2 compares the structure of some types of traditional DDS and the respective hybrid systems. Table 2 shows relevant information of main published works International Journal of Polymer Science 9 Emulgel-jojoba oil/HPMC Clotrimazole - [46] Emulgel-xanthan gum Acyclovir and ketoconazole - [47] Emulgel-lecithin soy Ketoprofen - [113] Nanogel-agar Sodium diclofenac - [48] Emulgel-CMC Sodium diclofenac - [114] Emulgel-gelatin Metronidazole - [45] Poly(SMA)-neocarzinostatin Neocarzinostatin - [115] PEG-DNA DNA - [52] PEG-streptavidin Streptavidin - [116] PEG-L-asparaginase L-Asparaginase - [53] PEG-streptavidin Streptavidin - [117] PDMA-BSA DNA - [57] PMMA-BSA Camptothecin 11.0% [56] ELP-FKBP Rapamycin - [58] Liposome-chitosan Doxorubicin 98.0 % [78] Liposome-cellulose Quercetin 40.0% [77] Liposome-cellulose Rutin 58.0% [77] Liposome-gel Lidocaine 21.6% [118] Liposome-gel Bupivacaine 98.8% [119] Liposome-alginate Benzocaine 63.2% [120] Liposome-PEG Lidocaine 98.8% [73] Cyclodextrin/liposome Quercetin 91.0% [121] Cyclodextrin/liposome Tretinoin 88.7% [122] Cyclodextrin/liposome Curcumin 50.0% [123] Cyclodextrin/PLGA Oxaprozin 62.0% [124] SLN-PLGA-PEG-PLGA [112] related to biohybrid systems for sustained delivery of therapeutic molecules.…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

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Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: 1mentioning

confidence: 99%

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…Gelling agents [11,12] These are the agents used to increase the consistency of any dosage form can also be used as thickening agent, as given in Table 5.…”

Section: Oils [1]mentioning

confidence: 99%

Untitled

Tanaji¹

2018

AJP

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In comparison with the other semisolid preparations, the use of gels has been emerged both in cosmetics and pharmaceutical preparations. When gel and emulsion used in the combined form, they are referred as Emulgel. Emulgel is the promising drug delivery system for the delivery of hydrophobic drugs. Emulgel is an emulsion which is gelled by mixing it with gelling agents. Many advantages of gels have the major limitation of delivery of hydrophobic drugs. Hence, to overcome this limitation, the emulsion based approach is being used. Emulgel is an interesting topical drug delivery system as it has dual release control system, i.e., gel and emulsion. Emulgels have several favorable properties for dermatological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, transparent, and pleasing appearance. Hence, emulgels can be used as better topical drug delivery system over present systems. This review gives knowledge about emulgel including its properties, advantages, and formulation considerations and its recent advances in the research field.

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“…The new approach in the field of topical drug delivery is introduced to deliver the hydrophobic drug that can enjoy the gelling property and whose rate can be controlled named Emulgel. It is simply where emulsion of the drug is prepared and that are incorporated in the gel [3].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Tioconazole Loaded Emulgel

2017

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Objective: The objective of the present work was to develop, characterize and evaluate the tioconazole loaded emulgel and to prove that emulgel can be the best alternative for delivery of hydrophobic drug topically.Methods: for the preparation of stable Emulgel, firstly gels were prepared using different polymers as carbopol 934 and xanthan gum, followed by preparation of emulsions and finally mixed together (table 1). Emulgel was evaluated for physical appearance, pH, spreadability, extrudability, viscosity, swelling index, dilution test, centrifuge test, drug content, in vitro release study, kinetic analysis of release data, antifungal activity and stability study for 3 mo. A comparative study was also performed between prepared emulgels with available marketed antifungal cream.Results: All evaluation parameters were in acceptable range with good physical appearance and the pH in the range of 5.5 to 6.8. The results show that the extrudability was in the range 15.63 to 35.27 g/cm 2 ; with spreadability in range of 6.6 to 8.833 cm. swelling index of F3 was seen a maximum in 3 h of about 75.13%. The viscosity was in the range of 15240 to 56340 cps at 10 RPM. During in vitro release of all formulations, F1 and F5 showed a maximum in vitro drug release of 59.11% and 55.11% respectively in 8 h. The kinetic analysis of fitting the data in different model shows that the best formulation of F1 fits in the Higuchi model with regression coefficient (R 2 ) of 0.998 and show non-fickian diffusion. The formulations were found stable. F1 and F5 provide a similar zone of inhibition like to market cream. Conclusion:Tioconazole emulgel provide the better platform for delivery of hydrophobic drug for topical route and so able to produce better patient compliance.

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Recent expansions in an emergent novel drug delivery technology: Emulgel

Cited by 177 publications

References 77 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Untitled

Development and Evaluation of Tioconazole Loaded Emulgel

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