Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Abstract

The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

“…In addition, considering that the zeta potential is a parameter related with the non-colloidal stability, the highly negative values observed in here (−36 mV) confirmed the shelftime of hybrid nanoemulsion (Honary and Zahir, 2013). In fact, ALG is the most successful biopolymer used as a carrier, absorption enhancer or adjuvant for DDS (Guo et al, 2020;Kuznetsova et al, 2020), as well as the polymer counterpart of organic-organic DDS (Ribeiro et al, 2017a;Siepmann et al, 2019).…”

Nanohybrid hydrogels designed for transbuccal anesthesia

“…However, the fluidity of that formulation was a serious limitation for its successful topical application. 16 Aiming to accomplish major advances in transbuccal anesthesia, we hybridized this NLC formulation with ALG, XAN, or CHT hydrogels. In the hybridization approach, benefits from the nanostructured particles and polymers were combined into a single pharmaceutical form: the sustained release profile of NLC-encapsulated LA and the appropriate viscosity, consistency, and adhesion of the biopolymer matrix, to provide efficient topical anesthesia of the oral mucosa.…”

“…14,15 The hybridization process of materials is an ancient practice, reported from the antique Egyptians. 16 In the DDS field, these advanced hybrid materials combine structural, physicochemical, mechanical, and therapeutic properties of each excipient in a single final form. Hybridization enables the development of smart formulations or pharmaceutical forms that are able to specifically interact with biological barriers, 17 such as the mucosal tissues and skin.…”

Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

“…Organic-organic nanostructured delivery systems are hybrid pharmaceutical forms composed of at least two different organic matrices: protein-polymer, protein-lipid, polymer-polymer or lipid-polymer [10]. This strategy combines the advantage of each excipient in a single system, providing specialized nanodevices for the specific interaction with the biological barrier of interest [11]. Among the nanohybrid systems, lipid-polymer nanoparticles and hybrid hydrogels are the most frequent systems reported in the literature for the sustained release of anesthetics, antineoplastics and antibiotics [12][13][14].…”