Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

Ribeiro, Lígia Nunes de Morais; Silva, Gustavo Henrique Rodrigues da; Couto, Verônica Muniz; Castro, Simone R.; Breitkreitz, Márcia Cristina; Martínez, Carolina; Igartúa, Daniela E.; Prieto, María Jimena; Paula, Eneida de

doi:10.3389/fchem.2020.589503

Cited by 7 publications

(4 citation statements)

References 66 publications

(82 reference statements)

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“…From a different perspective, the drug delivery system designed in this work could also be used as a nose-brain delivery system for the treatment of diseases such as migraine, cluster headache, and trigeminal neuralgia, for which the nasal route is preferable [67][68][69][70][71][72].…”

Section: Antinociceptive Testsmentioning

confidence: 99%

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

et al. 2021

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Recent advances have been reported for needle-free local anesthesia in maxillary teeth by administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain, fear, and stress. This work aimed to assess whether a TTC-loaded hybrid system could reduce cytotoxicity, promote sustained permeation, and increase the anesthetic efficacy of TTC for safe, effective, painless, and prolonged analgesia of the maxillary teeth in dental procedures. The hybrid system based on TTC (4%) encapsulated in nanostructured lipid carriers (NLC) and incorporated into a thermoreversible hydrogel of poloxamer 407 (TTCNLC-HG4%) displayed desirable rheological, mechanical, and mucoadhesive properties for topical application in the nasal cavity. Compared to control formulations, the use of TTCNLC-HG4% slowed in vitro permeation of the anesthetic across the nasal mucosa, maintained cytotoxicity against neuroblastoma cells, and provided a three-fold increase in analgesia duration, as observed using the tail-flick test in mice. The results obtained here open up perspectives for future clinical evaluation of the thermoreversible hybrid hydrogel, which contains TTC-loaded NLC, with the aim of creating an effective, topical, intranasal, needle-free anesthesia for use in dentistry.

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Section: Antinociceptive Testsmentioning

confidence: 99%

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

et al. 2021

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“…In addition, FE-SEM images successfully confirmed the XAN coating procedure, with a well-delimited and homogenous external layer ( Figure 5 D), acting as physical barrier to protect CHT and NLC-INDO to the degradation. Moreover, calorimetric analyses suggested good compatibility between the lipid–biopolymer blend and INDO, since the thermodynamic properties of XAN@CHT/NLC-INDO are very similar to that of NLC-INDO, the major component of nanobeads [ 15 , 40 ]. Still, no degradation peaks were observed in the thermograms, ensuring the thermal stability of the system up to 180 °C ( Figure 6 ), far above the physio/pathological temperature range (32.5–41.0 °C).…”

Section: Discussionmentioning

confidence: 99%

“…The nanobead combined a burst effect with prolonged release INDO profile. In fact, the Weibull model is widely employed to explain the complexes lipid–polymer DDS kinetics mechanisms [ 15 , 40 , 41 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Hybrid Nanobeads for Oral Indomethacin Delivery

et al. 2022

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The oral administration of the anti-inflammatory indomethacin (INDO) causes severe gastrointestinal side effects, which are intensified in chronic inflammatory conditions when a continuous treatment is mandatory. The development of hybrid delivery systems associates the benefits of different (nano) carriers in a single system, designed to improve the efficacy and/or minimize the toxicity of drugs. This work describes the preparation of hybrid nanobeads composed of nanostructured lipid carriers (NLC) loading INDO (2%; w/v) and chitosan, coated by xanthan. NLC formulations were monitored in a long-term stability study (25 °C). After one year, they showed suitable physicochemical properties (size < 250 nm, polydispersity < 0.2, zeta potential of −30 mV and spherical morphology) and an INDO encapsulation efficiency of 99%. The hybrid (lipid-biopolymers) nanobeads exhibited excellent compatibility between the biomaterials, as revealed by structural and thermodynamic properties, monodisperse size distribution, desirable in vitro water uptake and prolonged in vitro INDO release (26 h). The in vivo safety of hybrid nanobeads was confirmed by the chicken embryo (CE) toxicity test, considering the embryos viability, weights of CE and annexes and changes in the biochemical markers. The results point out a safe gastro-resistant pharmaceutical form for further efficacy assays.

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“…Nanoemulsion formulations possess unique properties such as high biocompatibility, ease of surface modification, and smaller size [10]. Nanoemulsion-based formulations are effective fortreating migraine, as they enhance the therapeutic efficacy and tolerability of antimigraine drugs [11]. Moreover, a nanoemulsion-based nanogel offers high patient acceptability, as it is non-invasive and easily applicable [12].…”

Section: Introductionmentioning

confidence: 99%

Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain

Sah,

Aggarwal,

Jain

et al. 2023

Gels

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The oil of the Unani medicinal herb Baboona (Matricaria chamomilla) has shown potential in the management of pain. However, predicaments such as poor skin penetration, skin sensitization, liable to degradation, and volatile nature restrict its use. Therefore, our group for the first time has developed a carrier-based delivery system to facilitate the direct application of chamomile oil to the forehead. The developed nanogel was characterized for physical parameters such as compatibility, TEM, and stability studies. Further, it was also evaluated for pH, viscosity, spread ability, and extrudability, as well as through texture analyses, in vitro studies, and skin irritation tests. The formulation was successfully developed with all the necessary attributes. The in vitro studies revealed the enhanced skin penetration of chamomile oil nanogel. The in vivo studies were also performed in chemically induced pain models, mimicking migraine. The studies show significant improvement of the pain threshold for chamomile nanogel when compared to the positive control group and the results were comparable to marketed diclofenac formulations. Finally, the encapsulation into nanogel reduced the skin irritation property. The nanogel formulation showed promising effects in the pain management of migraine.

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Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

Cited by 7 publications

References 66 publications

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

Hybrid Nanobeads for Oral Indomethacin Delivery

Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain

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