Real-time monitoring the alignment of x-ray beam relative to treatment target during radiation treatment based on ultrasound and x-ray acoustic dual-modality imaging (Conference Presentation)

Lei, Hao; Oraiqat, Ibrahim; Naqa, Issam El; Wang, Xueding

doi:10.1117/12.2289107

Cited by 4 publications

(5 citation statements)

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“…Specifically, iRAI would allow for real-time imaging of dose deposition that can be inherently registered with the exposed tissue anatomy image from US. 17,18 Several previous studies have demonstrated the feasibility of iRAI in providing clinically acceptable dosimetry from photons and electrons using either nontomographic or tomographic (XACT) methods during external beam radiation therapy, 15,16,19,20 as well as some early work on using the radiation acoustics generated from a pulsed proton beam to study the feasibility for noninvasive dose monitoring of a patient's liver. 21 However, the linearity of iRAI as a dosimetry tool under extremely high dose rates and the potential application of iRAI to guide FLASH-RT still have not been explored.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we hypothesize here that, when iRAI is combined with ultrasound imaging (US), this dual‐modality imaging will provide an effective way to guide FLASH‐RT delivery safely, in vivo , in real time. Specifically, iRAI would allow for real‐time imaging of dose deposition that can be inherently registered with the exposed tissue anatomy image from US 17,18 . Several previous studies have demonstrated the feasibility of iRAI in providing clinically acceptable dosimetry from photons and electrons using either nontomographic or tomographic (XACT) methods during external beam radiation therapy, 15,16,19,20 as well as some early work on using the radiation acoustics generated from a pulsed proton beam to study the feasibility for noninvasive dose monitoring of a patient’s liver 21 .…”

Section: Introductionmentioning

confidence: 99%

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An ionizing radiation acoustic imaging (iRAI) technique for real‐time dosimetric measurements for FLASH radiotherapy

et al. 2020

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Purpose: FLASH radiotherapy (FLASH-RT) is a novel irradiation modality with ultra-high dose rates (>40 Gy/s) that have shown tremendous promise for its ability to enhance normal tissue sparing while maintaining comparable tumor cell eradication toconventional radiotherapy (CONV-RT). Due to its extremely high dose rates, clinical translation of FLASH-RT is hampered by risky delivery and current limitations in dosimetric devices, which cannot accurately measure, in real time, dose at deeper tissue. This work aims to investigate ionizing radiation acoustic imaging (iRAI) as a promising image-guidance modality for real-time deep tissue dose measurements during FLASH-RT. The underlying hypothesis is that iRAI can enable mapping of dose deposition with respect to surrounding tissue with a single linear accelerator (linac) pulse precision in real time. In this work, the relationship between iRAI signal response and deposited dose was investigated as well as the feasibility of using a proof-of-concept dual-modality imaging system of ultrasound and iRAI for treatment beam co-localization with respect to underlying anatomy. Methods: Two experimental setups were used to study the feasibility of iRAI for FLASH-RT using 6 MeV electrons from a modified Varian Clinac. First, experiments were conducted using a single element focused transducer to take a series of point measurements in a gelatin phantom, which was compared with independent dose measurements using GAFchromic film. Secondly, an ultrasound and iRAI dual-modality imaging system utilizing a phased array transducer was used to take coregistered two-dimensional (2D) iRAI signal amplitude images as well as ultrasound B-mode images, to map the dose deposition with respect to surrounding anatomy in an ex vivo rabbit liver model with a single linac pulse precision. Results: Using a single element transducer, iRAI measurements showed a highly linear relationship between the iRAI signal amplitude and the linac dose per pulse (r 2 = 0.9998) with a repeatability precision of 1% and a dose resolution error <2.5% in a homogenous phantom when compared to GAFchromic film dose measurements. These phantom results were used to develop a calibration curve between the iRAI signal response and the delivered dose per pulse. Subsequently, a normalized depth dose curve was generated that agreed with film measurements with an RMSE of 0.0243, using correction factors to account for deviations in measurement conditions with respect to calibration. Experiments on the ex-vivo rabbit liver model demonstrated that a 2D iRAI image could be generated successfully from a single linac pulse, which was fused with the B-mode ultrasound image to provide information about the beam position with respect to surrounding anatomy in real time.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An ionizing radiation acoustic imaging (iRAI) technique for real‐time dosimetric measurements for FLASH radiotherapy

et al. 2020

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“…Integrating the information extracted from multiple complementary imaging modalities can offer a better evaluation and visualization of the region of interest. XACT in combination with US imaging was employed for monitoring the alignment of the X-ray beam with respect to the target during the session [37]. Dual modality imaging systems that employ co-registration of real-time dose deposition obtained from XACT with anatomical US images [38], [39] are also being developed.…”

Section: Model-based X-ray Induced Acoustic Computed Tomographymentioning

confidence: 99%

Model-Based X-Ray-Induced Acoustic Computed Tomography

Pandey

Wang

Aggrawal

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…Ironizing radiation acoustic imaging (iRAI) is a novel imaging concept with the potential to map the delivered radiation dose on anatomical structure in real time during external beam radiation therapy (RT) including conventional RT and FLASH mode RT [14][15][16] interest, providing adaptive feedback for safe and personalized cancer treatment. Described here is the proof of concept of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of complex clinical radiotherapy treatment plans with patients receiving radiation to liver tumor.…”

Section: Introductionmentioning

confidence: 99%

The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

Zhang,

Litzenberg,

Huang

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is the development of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of clinical radiotherapy treatment plan with patient receiving radiation to liver tumor. The real-time visualizations of radiation dose delivered have been archived in patients with liver tumor under a clinical linear accelerator. This proof-of-concept study demonstrated the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.

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Real-time monitoring the alignment of x-ray beam relative to treatment target during radiation treatment based on ultrasound and x-ray acoustic dual-modality imaging (Conference Presentation)

Cited by 4 publications

References 0 publications

An ionizing radiation acoustic imaging (iRAI) technique for real‐time dosimetric measurements for FLASH radiotherapy

An ionizing radiation acoustic imaging (iRAI) technique for real‐time dosimetric measurements for FLASH radiotherapy

Model-Based X-Ray-Induced Acoustic Computed Tomography

The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy

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