Model-Based X-Ray-Induced Acoustic Computed Tomography

Pandey, Prabodh Kumar; Wang, Siqi; Aggrawal, Hari Om; Bjegovic, Kristina; Boucher, S.; Xiang, Liangzhong

doi:10.1109/tuffc.2021.3098501

Cited by 17 publications

(24 citation statements)

References 55 publications

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“…However, we performed the simulations in 2D. The 2D simulations are known to mimic the detection of the acoustic waves using cylindrically focused transducers 65 . We further demonstrate how the layer‐by‐layer 2D slices can be reconstructed to make a 3D volumetric XACT image.…”

Section: Discussionmentioning

confidence: 94%

“…The 2D simulations are known to mimic the detection of the acoustic waves using cylindrically focused transducers. 65 We further demonstrate how the layer-by-layer 2D slices can be reconstructed to make a 3D volumetric XACT image. It may not be possible to collect the acoustic signals in full 3D geometry depending on the organ of interest in clinic.…”

Section: Discussionmentioning

confidence: 97%

“…44 Our recent publication has further demonstrated that XACT images can be performed with just a single-shot X-ray pulse in 50 ns. 65 (3) The one-way acoustic path in XACT rather than the round trip in pure ultrasound imaging. Compared with some emerge imaging technologies, for example, photoacoustic imaging, XACT imaging has deeper penetration depth with X-ray excitation and has great potential for clinical translation.…”

Section: Discussionmentioning

confidence: 99%

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The feasibility study of XACT imaging for characterizing osteoporosis

Samant

Cochran

et al. 2022

Medical Physics

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Background Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass and the deterioration in bone microarchitecture, which might be related to age and space travel. An unmet need exists for the development of novel imaging technologies to characterize osteoporosis. Purpose The purpose of our study is to investigate the feasibility of X‐ray‐induced acoustic computed tomography (XACT) imaging for osteoporosis detection. Methods An in‐house simulation workflow was developed to assess the ability of XACT for osteoporosis detection. To evaluate this simulation workflow, a three‐dimensional digital bone phantom for XACT imaging was created by a series of two‐dimensional micro‐computed tomography (micro‐CT) slices of normal and osteoporotic bones in mice. In XACT imaging, the initial acoustic pressure rise caused by the X‐ray induce acoustic (XA) effect is proportional to bone density. First, region growing was deployed for image segmentation of different materials inside the bone. Then k‐wave simulations were deployed to model XA wave propagation, attenuation, and detection. Finally, the time‐varying pressure signals detected at each transducer location were used to reconstruct the XACT image with a time‐reversal reconstruction algorithm. Results Through the simulated XACT images, cortical porosity has been calculated, and XA signal spectra slopes have been analyzed for the detection of osteoporosis. The results have demonstrated that osteoporotic bones have lower bone mineral density and higher spectra slopes. These findings from XACT images were in good agreement with porosity calculation from micro‐CT images. Conclusion This work explores the feasibility of using XACT imaging as a new imaging tool for Osteoporosis detection. Considering that acoustic signals are generated by X‐ray absorption, XACT imaging can be combined with traditional X‐ray imaging that holds potential for clinical management of osteoporosis and other bone diseases.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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The feasibility study of XACT imaging for characterizing osteoporosis

Samant

Cochran

et al. 2022

Medical Physics

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“…The main disadvantage of this method is its simplicity: lack of consideration of physical model of the transducer, scatter sources and heterogeneities in the medium (Grüneisen parameter, sound speed and attenuation). To solve this limitation, model-based reconstruction has been proposed 22 . This method can reconstruct quantitative information more accurately.…”

Section: Discussionmentioning

confidence: 99%

Single-pulse X-ray Acoustic Computed Tomography Image Guided Precision Radiation Therapy

Gonzalez

Prather

Pandey

et al. 2022

Preprint

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Cancer has been and continues to be a leading cause of death globally. More than half of all cancer patients undergo ionizing radiation therapy and dosimetry is crucial to the success and improvement of these treatments - ensuring that an accurate radiation dose is delivered to the target location. Despite widespread clinical use, the delivered dose can only be planned and verified via simulations with phantoms, and an in-tumor, on-line dose verification is still unavailable after more than one-hundred years of clinical application. X-ray-induced acoustic computed tomography (XACT) has recently shown the potential for imaging the delivered radiation dose within the tumor. Prior XACT imaging systems require tens of averages to achieve reasonable images. Here, we demonstrate that our XACT signals can be detected for each individual X-ray pulse (4µs) with sub-mGy sensitivity from a clinical linear accelerator during radiotherapy. Single-pulse XACT imaging holds great potential for personalized precision radiotherapy.

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“…Acoustic signals are of interest in the telecommunications industry for various remote applications, such as sonar for underwater civilian/military scenarios [ 1 , 2 , 3 ], modems for both aerial and underwater communications [ 4 , 5 , 6 ], as well as echography and other medical applications involving image reconstruction [ 7 , 8 , 9 ]. Networks of acoustic sensors, called wireless acoustic sensor networks (WASNs), are increasingly adopted to support sensing and monitoring applications in the emerging paradigm of the smart cities.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Dual-Function Communication and Echo-Location in Inaudible Band

Allegro

Fascista

Coluccia

2022

Sensors

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Acoustic communications are experiencing renewed interest as alternative solutions to traditional RF communications, not only in RF-denied environments (such as underwater) but also in areas where the electromagnetic (EM) spectrum is heavily shared among several wireless systems. By introducing additional dedicated channels, independent from the EM ones, acoustic systems can be used to ensure the continuity of some critical services such as communication, localization, detection, and sensing. In this paper, we design and implement a novel acoustic system that uses only low-cost off-the-shelf hardware and the transmission of a single, suitably designed signal in the inaudible band (18–22 kHz) to perform integrated sensing (ranging) and communication. The experimental testbed consists of a common home speaker transmitting acoustic signals to a smartphone, which receives them through the integrated microphone, and of an additional receiver exploiting the same signals to estimate distance information from a physical obstacle in the environment. The performance of the proposed dual-function system in terms of noise, data rate, and accuracy in distance estimation is experimentally evaluated in a real operational environment.

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Model-Based X-Ray-Induced Acoustic Computed Tomography

Cited by 17 publications

References 55 publications

The feasibility study of XACT imaging for characterizing osteoporosis

The feasibility study of XACT imaging for characterizing osteoporosis

Single-pulse X-ray Acoustic Computed Tomography Image Guided Precision Radiation Therapy

Acoustic Dual-Function Communication and Echo-Location in Inaudible Band

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