Reaction on a solid surface — A simple, economical, and efficient Mannich reaction of azacrown ethers over graphite

Abstract

Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100 °C for 20–30 min. The graphite powder can be reused up to three times after simple washing with acetone.Key words: azacrown ether, lariat ether, graphite, solvent-free, Mannich reaction.

Synthesis of new lariat ethers containing polycyclic phenols and heterocyclic aromatic compound on graphite surface via mannich reaction

“…We next screened CaO and graphite for Mannich reaction of azacrown ether 3 under similar conditions. We found the yields were further improved to 12-25% and graphite is better than CaO (entries 2, 3,5,6,8,9). In another study to increase the yield, experiments were done under solven-free condition in the presence of CaO and graphite.…”

“…We have previously shown that new lariat ethers can be prepared by the reaction of azacrown ether 3, phenols and paraformaldehyde on solid supported (CaO and graphite) [5,6]. In continuation of our interest in Mannich base synthesis, in peculiar on solid supports, we now described new method to the aminoalkylation of polycyclic and heterocyclic aromatic compounds.…”

Rapid, Eco‐friendly, and One‐pot Synthesis of New Lariat Ethers Based on Anthraquinone by Using ZnO Nanoparticles via “Mannich” Reaction under Solvent‐free Condition

“…This simplified reaction has received a growing attention from industrial research groups. “Mannich” reactions are among the most important one‐pot multicomponent reactions for the formation of the carbon–carbon bond . The resultant products acquired from “Mannich” reactions are important as synthetic versatile intermediates, natural products, and biologically active compounds .…”

Simple, Efficient, and Applicable Route for Synthesis of 2-Aryl(Heteroaryl)-Benzimidazoles at Room Temperature Using Copper Nanoparticles on Activated Carbon as a Reusable Heterogeneous Catalyst

“…Synthetic organic routes followed by using heterogeneous catalysts have advantages over their counterparts in which, used-catalyst can be easily recycled [21]. As a part of our continued efforts to utilize heterogeneous catalysts for developing organic reactions [37][38][39][40][41][42][43][44][45][46][47][48][49][50], herein we report on a new and reused catalyst system based on copper on charcoal (Cu/C). This heterogeneous catalyst system exhibits an excellent catalytic performance for the construction of the 2-arylbenzimidazoles framework.…”