Nowadays, CÀCb ond formation is one of the reaction types that most interests organic chemists. Thus, it has become an essential tool in organic synthesis that provides access to compounds of great value for different areas;s uch as materials, pharmaceuticals or fine chemicals. This kind of reactions can be performed under catalytic conditions employing transitionmetals,a sf or Suzuki-Miyaura, [1] Heck, [2] Negishi, [3] Stille, [4] Kumada, [5] Hiyama, [6] and Sonogashira reactions. [7] All thesea pproaches are typicallyp erformedi nv olatile organic solvents (VOC), whichn owadays are would preferably be replaced by "greener"m edia. Am ediumc an be considered green when its components satisfy different criteria,s uch as non-toxicity,r ecyclability,l ow price, availability,b iodegradability,a nd renewability,a mong others. Some deep eutectic solvents (DESs) could be considered as an alternative to hazardousV OC solvents. DESs are systemsf ormed by simple mixing Lewis or Brønsted acids and bases. [8] As ar esult of the strongh ydrogen bond interactions, the melting or phase transition point becamem uch lower than that of each individual component. [9] Nevertheless, the use of DES as reactionm edia in organic synthesis is in its childhood, [10 ] with very few reports of related metal-catalyzed process. [11] Only,v ery recently,p alladiumc hemistry has startedt ob e tested in DESm edia. More specifically, Suzukir eaction has been performed using Pd(OAc) 2 (10 mol %) in at ernary mixture of mannitol, dimethyl urea and ammonium chloride as DES combination. [12] Regarding Sonogashira coupling, the synthesis of only two products have been published in DES medium (dmannose/DMU), whereas the Heck cross-couplingr eaction has been performed in d-mannose-dimethyl urea (DMU) as reaction media. [13] Other publishedp alladium-catalyzed reactions performed in DES media include Ts uji-Trost allylation of amines in methylated b-cyclodextrine-DMU, [14 ] synthesis of thiophenes in ChCl-glycerol, [15] as well as the Stille reaction in lactose-DMU-NH 4 Cl. [16] This latest example is especially interesting, because is one of the few examples in which al igand was added to theD ES media:t riphenylarsine, in combination with palladium, permitted the coupling of 4-bromoanisole and tetraphenylstannanei n8 7% yield. However,w hen the reaction was performed using CyJohnPhos (a Hartwig-Buchwald-type ligand), only am odest6 1% yield was obtained. These facts clearlyd emonstrate the importance of appropriate design of the ligand in order to get good results in this new media.With all these precedents, we aimed to develop DES compatible phosphine ligands, since the best traditional palladium ligandsf or cross-coupling reactions seemed not to be so effective in this kind of solvents. We thoughi nc ationic pyridiniophosphine structures [17] as general strategy for ligandsi nt he palladium-catalyzed cross-couplingr eactions.We started by the synthesis of ac ationic pyridiniophosphine ligand with ac hloride as counter ion (Scheme 1). In order ...

In this paper, we have introduced {Fe3O4@SiO2@(CH2)3Im}C(NO2)3 as a novel and heterogeneous reusable catalyst for the four component preparation of the polyhydroquinoline derivatives under mild and eco-friendly reaction conditions. The structural confirmation of the novel heterogeneous reusable promoter was fully made using appropriate technical skills such as FT-IR, X-ray diffraction patterns (XRD), Field emission scanning electron microscopy (FESEM), Energy-dispersive spectroscopy (EDS) elemental mapping analysis, High Resolution transmission electron microscopy (HRTEM), thermogravimetry (TG), derivative thermal gravimetric (DTG), differential thermal (DTA) and vibrating sample magnetometer (VSM) analysis. The presented nano magnetic heterogeneous catalyst was successfully applied for the synthesis of the polyhydroquinoline derivatives via a four component condensation of a good range arylaldehydes, dimedone, ethyl acetoacetate or methyl acetoacetate as β-ketoester, and ammonium acetate as nitrogen source under solvent free conditions. Also, the experimental evidence has demonstrated that the {Fe3O4@SiO2@(CH2)3Im}C(NO2)3 could act as a nano magnetically recoverable and reusable catalyst without any meaningful drop in the yield and the reaction time at least for eight times.

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1,4-Dihydropyridines and 2,4,6-triarylpyridines were synthesized via anomeric based oxidation using chitosan supported vanadium oxo.

A convenient method for the synthesis of pyrido[2,3‐d]pyrimidines by using the novel nano‐magnetic silica‐bonded S‐sulfonic acid[Fe3O4@SiO2@(CH2)3S–SO3H] as an efficient and recyclable catalyst under neat conditions is described. The major advantages of the present methodology are high yield, short reaction time, and reusability of the catalyst. Furthermore, the nano‐magnetic silica‐bonded S‐sulfonic acid was fully characterized by using various techniques such as FT‐IR, TG/DTG, DTA, EDX, μXRF, XRD, HRTEM, SEM, SEM elemental mapping, XPS, and N2 physisorption. The results obtained from this research support the idea of rational design, synthesis, and applications of task‐specific and reusable catalysts for the preparation of various polynitrogenated heterocyclic compounds containing 1,4‐dihydropyridine moieties.

A very efficient and highly regioselective ring-opening reaction of epoxides with benzoic acid and its derivatives in the presence of cat. amount of tetrabutylammonium bromide (TBAB) in anhydrous acetonitrile has been developed. This effective method is useful for the preparation of selectively protected diols as precursor for many organic syntheses such as those of acyclic nucleosides and other synthetic purposes. The advantages of this method are efficiency, selectivity, low cost, and the applicability in large-scale synthesis of β-benzoyloxyalkanols.