An efficient catalytic method for the synthesis of pyrido[2,3‐d]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst

Abstract

A convenient method for the synthesis of pyrido[2,3‐d]pyrimidines by using the novel nano‐magnetic silica‐bonded S‐sulfonic acid[Fe3O4@SiO2@(CH2)3S–SO3H] as an efficient and recyclable catalyst under neat conditions is described. The major advantages of the present methodology are high yield, short reaction time, and reusability of the catalyst. Furthermore, the nano‐magnetic silica‐bonded S‐sulfonic acid was fully characterized by using various techniques such as FT‐IR, TG/DTG, DTA, EDX, μXRF, XRD, HRTEM, SEM, SEM elemental mapping, XPS, and N2 physisorption. The results obtained from this research support the idea of rational design, synthesis, and applications of task‐specific and reusable catalysts for the preparation of various polynitrogenated heterocyclic compounds containing 1,4‐dihydropyridine moieties.

A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds

“…Later, in 2016, urea (fertilizer)-based ionic liquid (IL)-stabilized Fe 3 O 4 MNPs were successfully used as catalysts for the synthesis of 179b in excellent yields without the use of any solvent at 60 C. 193 Further, in 2017, Zarei et al reported the synthesis of 183 using silica-bonded S-sulfonic acid-supported ferromagnetic MNPs without solvent at 100 C using 2, 29a and 2,4-diamino-6-hydroxypyrimidines. 194 Maleki et al also reported the similar synthesis of 179b using biodegradable and eco-friendly catalysts such as cellulose-based nanocomposites anchored on Fe 3 O 4 in water at rt in 76-98% yield. 195 Pal et al reported the one-pot multicomponent synthesis of dihydropyrano [2,3- .…”

Copper and nickel immobilized on cytosine@MCM‐41: as highly efficient, reusable and organic–inorganic hybrid nanocatalysts for the homoselective synthesis of tetrazoles and pyranopyrazoles

“…In recent years, there has been a rapid growth in the development of novel supported compounds such as supported catalysts, reagents, sensors and adsorbents. [1][2][3][4][5][6][7] Therefore, nanoparticles have been widely used as solid supports for the immobilization of homogeneous catalysts. [8][9][10] For example, silica materials, [11] polymers, [12] graphene oxide, [13][14][15][16] carbon nanotubes, [17] iron oxide, [18] ionic liquids, [19,20] boehmite nanoparticles, [21,22] biochar, [23] magnetic nanoparticles, [24][25][26] etc.…”

A novel nanomagnetic solid acid catalyst for the synthesis of new functionalized bis‐coumarin derivatives under microwave irradiations in green conditions

“…Moreover, surface modification of magnetic nanoparticles is an allowable method to eliminate the giant gap between homogeneous and heterogeneous catalysts 63–67 . Sulfuric acid is used as an efficient and irretrievable Brønsted–Lowry acid catalyst to generate different kinds of chemical materials 68–71 . Sulfonation with sulfosalicylic acid as a suitable, quick, and executable system has attracted great attention for the production of heterogeneous catalysts 72 .…”