Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish

He, Xiaojun; Chen, Hong; Xu, Chuchu; Fan, Jinyi; Xu, Wei; Li, Yahui; Deng, Hui; Shen, Jianliang

doi:10.1016/j.jhazmat.2020.122029

Cited by 101 publications

(31 citation statements)

References 41 publications

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“…Zebrafish experiments proved that BK was organism-permeable and can monitor ClO − in living organisms. Importantly, BK is the first fluorescent turn-off sensor capable of sensing ClO − in zebrafish ( Table S1 ) [ 1 , 38 , 54 , 55 , 56 , 57 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

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An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

Lee

Park

et al. 2020

Sensors

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A novel acridine-based fluorescent chemosensor, BK ((E)-2-((acridine-9-ylimino)methyl)-N-benzhydrylhydrazine-1-carbothioamide), for monitoring ClO− was prepared. The sensor BK was synthesized by introducing a new synthetic route of making aldehyde group using formic hydrazide. Probe BK displayed notable fluorescence quenching in the presence of ClO− and showed a great selectivity over other guest analytes. The detection limit was calculated to be 7.65 μM. Additionally, BK was satisfactorily applied for sensing ClO− in water samples and zebrafish.

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Section: Resultsmentioning

confidence: 99%

“…However, some of them have disadvantages like complicated synthetic routes, poor water solubility and being unsuitable for biological application. Thus, there is still a need to further exploit new fluorescent chemosensors for sensing ClO − in vitro as well as in biological systems [ 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

Lee

Park

et al. 2020

Sensors

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“…3). Other substances (10 μ m ) of WO2‐4, AlO‐2, Fe 3+ , Ca 2+ , chlorpyrifos (CHP), Thr, Trp, phe, Val, acephate, penicillin (PG), Cl ‐ , Na + , Mg 2+ , Pb 2+ , Co 2+ Cu 2+ , Zn 2+ , Cr 3+ , Al 3+ , Ga 3+ , In 3+ do not change the luminescence of the mixtures, indicating that Tb complex is a “turn off” luminescent chemical sensor for Cd 2+ (32–36). The same experiment was also performed on Eu complex; result shows that Eu complex is not a sensor for acac or Cd 2+ (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Luminescent Lanthanide Complex Sensor for Acac and Cd²⁺

Chen

Cai

et al. 2020

Photochem & Photobiology

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In this work, phenylmalonic acid (H2pmal) and phenanthroline (phen) are selected to react with Ln(NO3)3·6H2O (Ln = Tb, Eu) to form two lanthanide coordination complex [Ln2(PAA)4(phen)2(NO3)2] (Ln = Tb, Tb complex; Eu, Eu complex), PAA = deprotonated phenylacetic acid, phen = 1,10‐phenanthroline). Two lanthanide complexes are stable in neutral, acid (pH = 4) and base (pH = 10) water solutions. Especially, Tb complex is a bifunctional sensor for acac and Cd2+, through luminescence “turn on” and “turn off,” respectively. Importantly, the limit of detections (LODs) for acac and Cd2+ are 90 nm and 0.5 μm, respectively. Furthermore, the sensing mechanisms are discussed in detail.

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“…However, the lack of effective antimicrobial agents to combat MDR pathogens has led to the resurgence of last-resort antibiotics including polymyxins (polymyxin B and colistin) to control MDR Gram-negative bacterial infections [3]. Researchers are also trying in different ways such as detection of bacteria which can be utilized to kill bacterial cells [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant Escherichia coli

et al. 2021

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Resistance to polymyxins when treating multidrug-resistant (MDR) Gram-negative bacterial infections limit therapeutic options. Here, we report the synthesis of a nickel (Ni) doped Zinc oxide (NZO) combined with black phosphorus (BP) (NZB) nanocomposite and its synergistic action with polymyxin B (PolB) against polymyxin-resistant Escherichia coli harboring mobilized colistin resistance (mcr-1) gene. NZB and PolB combination therapy expressed a specific and strong synergy against Mcr-1 expressing E. coli cells. The underlying mechanism of the synergy is the charge neutralization of the E. coli cell surface by NZB, resulting in a more feasible incorporation of PolB to E. coli. The synergistic concentration of NZB with PolB was proved biocompatible. Thus, the NZB is the first biocompatible nano-adjuvant to polymyxins against polymyxin-resistant E. coli cells, recognizing the physical status of bacteria instead of known adjuvants targeting cellular gene products. Therefore, NZB has the potential to revive polymyxins as leading last-resort antibiotics to combat polymyxin-resistant Gram-negative bacterial infections.

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Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish

Cited by 101 publications

References 41 publications

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

Luminescent Lanthanide Complex Sensor for Acac and Cd²⁺

A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant Escherichia coli

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Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish

Cited by 101 publications

References 41 publications

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

Luminescent Lanthanide Complex Sensor for Acac and Cd2+

A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant Escherichia coli

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Product

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Luminescent Lanthanide Complex Sensor for Acac and Cd²⁺