Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans

Faix, Dennis J.; Sherman, Sterling S.; Waterman, Steven H.

doi:10.1056/nejmc0904264

Cited by 256 publications

(182 citation statements)

References 2 publications

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“…In a CDC study of 45 samples provided by state laboratories, the sensitivity of all rapid tests was 40%–69%, including 69% for QuickVue Influenza A+B ( 6 ). Others have found the QuickVue rapid tests to have sensitivities of 51%–63% and specificities of 99%–100% ( 7 – 9 ). During a large cluster of school outbreaks in New York, NY, USA, the sensitivity and specificity of the Binax NOW (Inverness Medical International, Bedford, UK) rapid test were 17.8% and 93.6%, respectively ( 10 ).…”

Section: The Studymentioning

confidence: 99%

Rapid Influenza Antigen Test for Diagnosis of Pandemic (H1N1) 2009

Louie¹,

Guevara²,

Boston³

et al. 2010

Emerg. Infect. Dis.

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Section: The Studymentioning

confidence: 99%

Rapid Influenza Antigen Test for Diagnosis of Pandemic (H1N1) 2009

Louie¹,

Guevara²,

Boston³

et al. 2010

Emerg. Infect. Dis.

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“…The sensitivity of all rapid tests decreased markedly with decreasing virus titres in specimens (51). However, the reported specificity was consistently greater than 93% (50,52). DFA showed comparable specificity to rapid antigen tests (99.6% vs. 99.5%), but higher sensitivity (47.2% vs. 21.2%) (50).…”

Section: Laboratory Diagnosismentioning

confidence: 99%

“…Rapid antigen tests generally have low sensitivity (11%-69%) for detecting pandemic H1N1/09 (50)(51)(52)(53)(54). The sensitivity of all rapid tests decreased markedly with decreasing virus titres in specimens (51).…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Pandemic influenza A (H1N1) 2009: the experience of the first six months

Maritz

Maree²,

Preiser³

2009

Clinical Chemistry and Laboratory Medicine

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After a break of 41 years, 2009 saw the first influenza pandemic of the 21st century caused by a triple-reassortant influenza A (H1N1) virus. The current estimated case fatality rate is lower than that of previous influenza pandemics, but this may change as the pandemic evolves. Illness frequently occurs in previously healthy, young adults with a wide range of clinical presentations. The majority of circulating pandemic viruses remain susceptible to neuraminidase inhibitors, although all strains are intrinsically resistant to the adamantanes. Monovalent vaccines against the pandemic strain are available in both live attenuated and inactivated forms. This review aims to summarise important virological, epidemiological and clinical aspects of the pandemic influenza A (H1N1) virus for physicians and other clinical personnel. Clin Chem Lab Med 2010;48:11-21.

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“…Data on analytical sensitivity for detection of different viruses does not directly refl ect clinical sensitivity on patient specimens. However, only limited data have been published on the performance of RIDTs compared with RT-PCR for detecting the presence of novel infl uenza A (H1N1) virus in clinical specimens [19]. Compared to RT-PCR, the sensitivity of RIDTs for detecting novel infl uenza A (H1N1) virus infections ranged from 10% to 70%.…”

Section: Antigen Detectionmentioning

confidence: 99%

Diagnosis of influenza viruses with special reference to novel H1N1 2009 influenza virus

2009

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On 15 April and 17 April 2009, novel swineorigin infl uenza A (H1N1) virus was identifi ed in specimens obtained from two epidemiologically unlinked patients in the United States. The ongoing outbreak of novel H1N1 2009 infl uenza (swine infl uenza) has caused more than 3,99,232 laboratory confi rmed cases of pandemic infl uenza H1N1 and over 4735 deaths globally. This novel 2009 infl uenza virus designated as H1N1 A/swine/California/04/2009 virus is not zoonotic swine fl u and is transmitted from person to person and has higher transmissibility then that of seasonal infl uenza viruses. In India the novel H1N1 virus infection has been reported from all over the country. A total of 68,919 samples from clinically suspected persons have been tested for infl uenza A H1N1 across the country and 13,330 (18.9%) of them have been found positive with 427 deaths. At the All India Institute of Medical Sciences, New Delhi India, we tested 1096 clinical samples for the presence of novel H1N1 infl uenza virus and seasonal infl uenza viruses. Of these 1096 samples, 194 samples (17.7%) were positive for novel H1N1 infl uenza virus and 197 samples (18%) were positive for seasonal infl uenza viruses. During outbreaks of emerging infectious diseases accurate and rapid diagnosis is critical for minimizing further spread through timely implementation of appropriate vaccines and antiviral treatment. Since the symptoms of novel H1N1 infl uenza infection are not specifi c, laboratory confi rmation of suspected cases is of prime importance.

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Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans

Cited by 256 publications

References 2 publications

Rapid Influenza Antigen Test for Diagnosis of Pandemic (H1N1) 2009

Rapid Influenza Antigen Test for Diagnosis of Pandemic (H1N1) 2009

Pandemic influenza A (H1N1) 2009: the experience of the first six months

Diagnosis of influenza viruses with special reference to novel H1N1 2009 influenza virus

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