RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma

Sohn, Myung Hyun; Kim, Seung Hyun; Kim, Kyung Won; Jee, Hye Mi; Park, Hae‐Sim; Kim, Kyu-Earn

doi:10.1007/s00408-007-9049-3

Cited by 13 publications

(13 citation statements)

References 31 publications

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“…Our results were consistent with previous report in Korean children,[29] where no significant differences in clinical characteristics according to the genotypes of RANTES -403G/A polymorphism were observed. Also, in the Hungarian study,[30] no clinical or laboratory characteristics were associated with a given RANTES genotype.…”

Section: Discussionsupporting

confidence: 93%

“…These results were consistent with reports from Korean,[29] Japanese,[21] Hungarian,[30] Spanish,[31] and African American[32] populations where RANTES promoter polymorphism did not have a significant effect on the susceptibility to asthma.…”

Section: Discussionsupporting

confidence: 92%

“…[34] However, a meta-analysis comprising several studies[212229–3237] was carried out by Zhang et al .,[36] and confirmed the absence of significant associations of the -403G/A and -28C/G polymorphisms with asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Enzyme digestion (RFLP) was carried out as described previously;[2829] in a 15 μl final volume using 5 μl of PCR product and: 3 U of MnlI (Fermentas) enzyme for RANTES-28C/G, the reactions were incubated at 37°C overnight, the wild- type allele was detected as five bands (114, 27, 20, and two 13 bp), while heterozygous individuals with CG genotype, three bands were revealed (134, 27, and two 13 bp) or 4 U of MaeIII (Roche Diagnostics GmbH) enzyme for RANTES -403G/A, the reactions were incubated at 55°C overnight; Digestion with MaeIII yields 112 and 23 bp fragments when G allele is present, while the mutant A allele was detected as a band of 135 bp. The digested products were subjected to electrophoresis on 3% agarose gel stained with ethidium bromide.…”

Section: Methodsmentioning

confidence: 99%

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Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon

Nahas¹,

Chmaisse²,

Makki³

2012

Ann Thorac Med

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CONTEXT:Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies.AIM:The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon.SETTINGS AND DESIGN:This case control study was conducted at Makassed Hospital, Beirut on 40 asthmatic patients and 38 healthy controls.METHODS:RANTES gene polymorphisms -403G/A and -28C/G alleles were genotyped using PCR-RFLP.RESULTS:No significant differences in allele or genotype frequencies for the RANTES gene polymorphisms between asthmatic patients and controls were found. The difference of the -403 GA genotype frequency between patients and controls was not statisti-cally significant; (OR=0.8, 95% CI=0.2-2.3, P=0.8). Similarly, the difference of the A-allele frequencies between patients and con-trols was not significant (OR=0.824, CI=0.3–2.2, P=0.7).CONCLUSIONS:Our data show that RANTES gene promoter polymorphisms are not associated with asthma susceptibility in the Lebanese population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon

Nahas¹,

Chmaisse²,

Makki³

2012

Ann Thorac Med

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“…Asthma is a chronic inflammatory disorder of the airways and is characterized by variable airflow obstruction and bronchial hyper responsiveness (BHR) 1. The prevalence and severity of asthma have been increasing in many countries, the trends being most pronounced for children and adolescents 2.…”

Section: Introductionmentioning

confidence: 99%

Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk - A Meta-Analysis

Fang

Wang²,

Zhao³

2010

Int. J. Med. Sci.

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Regulated upon activation, normal T-cell expressed and secreted (RANTES) is one of the most extensively studied C-C chemokines in allergic inflammation. A growing body of evidence suggests that many cell types present in asthmatic airways have the capacity to generate RANTES, which directly supported the potential role of RANTES in asthma. A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility. However, the results remain conflicting rather than conclusive. This meta-analysis on 1894 asthma cases and 1766 controls for -28C/G from 9 published case-control studies showed that the variant allele -28G was associated with significantly increased risk of asthma (GG+CG vs CC: OR=1.24, 95%CI=1.08-1.41) without any between-study heterogeneity.In the stratified analysis by asthma type, age and ethnicity, we found that the increased asthma risk associated with -28G/C polymorphism was more evident in children (OR=1.24, 95%CI=1.06-1.45), Asian group (OR=1.27, 95%CI=1.04-1.56) and African group (OR=1.72, 95%CI=1.07-2.78). These results suggest that RANTES -28G/C polymorphism may contribute to asthma development, especially in children and in Asian population. Additional well-designed large studies were required for the validation of this association.

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The Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES) −28C/G and −403G/A Polymorphisms and Asthma Risk: A Meta-analysis

et al. 2014

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RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma

Cited by 13 publications

References 31 publications

Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon

Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon

Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk - A Meta-Analysis

The Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES) −28C/G and −403G/A Polymorphisms and Asthma Risk: A Meta-analysis

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