Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk - A Meta-Analysis

Abstract

Regulated upon activation, normal T-cell expressed and secreted (RANTES) is one of the most extensively studied C-C chemokines in allergic inflammation. A growing body of evidence suggests that many cell types present in asthmatic airways have the capacity to generate RANTES, which directly supported the potential role of RANTES in asthma. A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility. However, the results remain conflicting rather than conclusive. This meta-analysis on 1894 asthma cases and 1766 controls for -28C/G from 9 published case-control studies showed that the variant allele -28G was associated with significantly increased risk of asthma (GG+CG vs CC: OR=1.24, 95%CI=1.08-1.41) without any between-study heterogeneity.In the stratified analysis by asthma type, age and ethnicity, we found that the increased asthma risk associated with -28G/C polymorphism was more evident in children (OR=1.24, 95%CI=1.06-1.45), Asian group (OR=1.27, 95%CI=1.04-1.56) and African group (OR=1.72, 95%CI=1.07-2.78). These results suggest that RANTES -28G/C polymorphism may contribute to asthma development, especially in children and in Asian population. Additional well-designed large studies were required for the validation of this association.

Interleukin-13 and RANTES polymorphisms in relation to asthma in children of Chinese Han nationality

“…They found that IL13 A2044G and RANTES G-28C were associated with an increased risk of athma in Asian populations. [20][21] We also observed that carriers of both A044G A/A and G-28C G/G had a more significant risk of developing asthma than those with either a single SNP, thus suggesting that synergism existed between the A2044G A/A and G-28C G/G genotypes.…”

Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis

“…Up to now, there were four meta-analysis investigations indicating controversial results about the correlation between these two polymorphisms and asthma. Three studies about the association of RANTES gene polymorphisms and asthma susceptibility reported that −28C/G polymorphism could increase the risk of asthma in Asian children or pediatric asthma in global population, while no relationship was found in −403G/A [35] , [36] , [37] . However, Zhang et al [38] observed contrary findings showing that −403G/A polymorphism would be a risk factor among atopic asthma patients, and no such association was indicated in −28C/G, which is consistent with our findings.…”

Association between serotonin transporter gene polymorphisms and childhood asthma

“…Promoter polymorphism of RANTES has shown to be related with atopic dermatitis [35]. Some reports have shown a relation between functional polymorphisms in the RANTES gene promoter and asthma [36,37].…”