Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon

Abstract

CONTEXT:Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies.AIM:The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon.SETTINGS AND DESIGN:This case control study was conducted at Makassed Hospital, Beirut on 40 asthmatic patients and 38 healthy controls.METHODS:RANTES gene polymorphisms -403G/A and -28C/G alleles were genotyped using PCR-RFLP.RESULTS:No significant differences in allele or genotype frequencies for the RANTES gene polymorphisms between asthmatic patients and controls were found. The difference of the -403 GA genotype frequency between patients and controls was not statisti-cally significant; (OR=0.8, 95% CI=0.2-2.3, P=0.8). Similarly, the difference of the A-allele frequencies between patients and con-trols was not significant (OR=0.824, CI=0.3–2.2, P=0.7).CONCLUSIONS:Our data show that RANTES gene promoter polymorphisms are not associated with asthma susceptibility in the Lebanese population.

Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis

“…In other countries, both −403G/A and −28C/G polymorphisms did not have a detectable effect on asthma susceptibility in African Americans, Lebanon, Spanish or Budapest population, respectively [12], [18], [25], [27]. However, Lachheb et al [23] suggested that both polymorphisms may play an important role in asthma predisposition, airway obstruction severity, or bronchial hyperresponsiveness among Tunisian or Korean children.…”

Evidence from genetic studies among rs2107538 variant in the CCL5 gene and Saudi patients diagnosed with type 2 diabetes mellitus

“…There have been limited studies on T2DM among the global population that has been associated with lower and higher risk ( Böger et al, 2005 , Herder et al, 2008 , Kochetova et al, 2019 , Lee et al, 2021 , Prasad et al, 2007 ) and our study was highly associated with an average risk × 4.3. Consequently, the variant rs2107538 has been studied in various human diseases such as GDM ( Teler et al, 2017 ), PTDM ( Joo et al, 2007 , Jeong et al, 2010 ), cardiovascular ( Mohtavinejad et al, 2021 ) and coronary artery diseases ( Lee et al, 2021 , Ting et al, 2015 , Liu et al, 2012 , Duell et al, 2006 ), myocardial infarction ( Tereshchenko et al, 2011 ), asthma ( Nahas et al, 2012 , Lu et al, 2012 ), prostatic hyperplasia ( Pang et al, 2019 ), and cancers such as prostate cancer ( Kidd et al, 2012 ), oral and pancreatic cancers ( Weng et al, 2010 , Duell et al, 2006 ). Furthermore, these variants were studied in meta -analyses alongside tuberculosis ( Sheng and Qi, 2020b ) and cancer ( Ying et al, 2014 ).…”