The Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES) −28C/G and −403G/A Polymorphisms and Asthma Risk: A Meta-analysis

Xie, Z.; Zhao, Hua; Huang, Jian; Xie, Zijian

doi:10.1007/s40291-014-0112-5

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…It has been shown that RANTES stimulates maturation of DCs. Dendritic cells play a crucial role in tolerance induction by production of Tregs and secretion of cytokines [30,31]. In considering the increase of eosinophils in the circulation during the initial phase of VIT we assume that CCL5/RANTES and DCs' cytokines may result in the eosinophil response.…”

Section: Discussionmentioning

confidence: 99%

Expression of eosinophils, RANTES and IL-25 in the first phase of Hymenoptera venom immunotherapy

Pałgan

Żbikowska-Gotz

Bartuzi

2020

pdia

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Introduction: Venom immunotherapy (VIT) can protect against severe anaphylactic reactions (SR) in 80-100% of subjects allergic to Hymenoptera venom. The mechanisms of induction of immunological tolerance produced by VIT are still little known. It has been shown that VIT modulates Treg activity, Th2 or Th1 cells or both, increases production of IL-10, decreases secretion of IL-13, and causes an IgG4/IgE ratio shift. Aim: To investigate the blood eosinophil count, CCL5/RANTES and IL-17E/IL-25 concentrations before and after the initial phases of the rush protocol of VIT. Material and methods: Forty individuals (14 males, 26 females) of mean age 41.03 ±12.43 years were included in the study. The peripheral eosinophils and the concentration of serum interleukin IL-17E/IL-25 and RANTES were determined before and after the initial phase of VIT. Results: Paired sample t-test revealed that all patients after VIT had significantly higher eosinophil levels compared to the baseline (mean: 0.42 vs. 0.64, p < 0.05). Moreover, in subjects treated with bee venom, RANTES levels proved to rise significantly (51 × 10 3 vs. 62 × 10 3 , p < 0.05) while IL-17E/IL-25 dropped with near-marginal significance (916 vs. 650, p = 0.069). Conclusions: Our immunological study on the early phase of venom immunotherapy suggested that eosinophils, cytokines such as CCL5/RANTES and IL-17E/IL-25 contribute to the immunological response.

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Section: Discussionmentioning

confidence: 99%

Expression of eosinophils, RANTES and IL-25 in the first phase of Hymenoptera venom immunotherapy

Pałgan

Żbikowska-Gotz

Bartuzi

2020

pdia

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“…Twenty-seven SNPs of twelve genes with a minor allele frequency > 0.05 in Han Chinese were selected. These 27 SNPs in 12 chemokine genes, included 4 SNPs (rs1024610, rs1024611, rs13900, and rs4586) of CCL2 [21, 22], 5 SNPs (rs4251719, rs2306630, rs2107538, rs9355610, and rs2280788) of CCL5 [12, 23, 24], 1 SNP (rs854680) of CCL16 [25], 2 SNPs (rs223828 and rs223895) of CCL17 [26–28], 3 SNPs (rs951005, rs2492358, and rs2812378) of CCL21 [29–31], 1 SNP (rs4359426) of CCL22 [32], 2 SNPs (rs2302004 and rs2302005) of CCL24 [33], 3 SNPs (rs2227306, rs2227543, and rs4694178) of CXCL8 [34], 2 SNPs (rs2276886 and rs2869460) of CXCL9 [14, 35], 1 SNP (rs2869462) of CXCL10 [35], 2 SNPs (rs1801157 and rs2839693) of CXCL12 [13, 15], and 1 SNP (rs2277680) of CXCL16 [36]. We excluded rs1024611 of CCL2 , since a study concerning this gene had been reported previously by our group [18].…”

Section: Methodsmentioning

confidence: 99%

The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population

Huang

Cao

et al. 2017

BioMed Research International

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To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, Puncorr values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals. Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH. Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease. However, no significant association was observed after Bonferroni correction. This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.

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“…On the other hand, the levels of CCL5 presented significant differences between patients with allergic and non-allergic rhinopathies and polyps vs. those with normal mucosa (84), which suggest its contribution to leukocyte infiltration and activation related to inflammation. Two CCL5'SNPs (located at -403G/A and -28C/G) were evaluated and associated with the risk of asthma in Asian and Caucasian populations (85). CCL13 (MCP-4), a CC able to induce crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells was also measured in studies investigating asthma and rhinitis.…”

Section: Chemokinesmentioning

confidence: 99%

Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)

et al. 2020

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Allergic diseases have been classified in the last decades using various theories. The main classes of the newest classification in allergic respiratory diseases focus on the characterization of the endotype (which takes into account biomarkers related to determinant pathophysiological mechanisms) and of the phenotype (based on the description of the disease). Th2, Th1 and Th17 lymphocytes and the type of inflammatory response mediated by them represent the basis for Th2 and non-Th2 endotype classification. In addition, new lymphocytes were also used to characterize allergic diseases: Th9 lymphocytes, Th22 lymphocytes, T follicular helper cells (T FH) lymphocytes and invariant natural killer T (iNKT) lymphocytes. In the last decade, a growing body of evidence focused on chemokines, chemoattractant cytokines, which seems to have an important contribution to the pathogenesis of this pathology. This review presents the interactions between chemokines and Th lymphocytes in the context of Th2/non-Th2 endotype classification of respiratory allergies.

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The Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES) −28C/G and −403G/A Polymorphisms and Asthma Risk: A Meta-analysis

Abstract: Current findings suggest an association between the -28G allele and asthma risk in Asian children but not in Caucasian children.

Cited by 5 publications

References 28 publications

Expression of eosinophils, RANTES and IL-25 in the first phase of Hymenoptera venom immunotherapy

Expression of eosinophils, RANTES and IL-25 in the first phase of Hymenoptera venom immunotherapy

The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population

Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)

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