Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets

Abstract

Over the years, Electroanalysis has been widely applied to elucidate redox behavior of novel molecules. The selectivity and low cost are spotlight features in pharmacopeial methods of identification, that can be reached by voltammetric approaches. In this work, differential pulse voltammetric (DPV) profile and the slope of the linear regression obtained from calibration graphs along with the scan study are proposed as new perspective of identification assays. With the proposed methodology we were able to identify the similarities among DPV profile and the slopes obtained for each tablet. In addition, this new technology was successfully employed to identify the following chemicals: Paracetamol (PAR), Promethazine (PMZ), Diclofenac (DIC), Piroxicam (PRX), Indomethacin (IND) and Cyclobenzaprine (CBP) in pharmaceutical assays using Pencil Graphite Electrodes. Furthermore, our new methodology was effectively compared to Raman Spectroscopy for the analysis of the range of chemicals in the pharmaceutical assays.

Review—Pencil Graphite Electrode: An Emerging Sensing Material

“…2A). [31][32][33][34][35][36] For redox behavior, the HB pencil revealed equal electron-transfer as that on other carbon based electrodes. Overall it may be concluded that PGE represents a cheap and disposable sensor for electrochemical measurements in comparison to other more expensive commercial carbon electrodes.…”

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

“…The application of electrochemical techniques in the analysis of drugs and pharmaceutical products either in biological medium has increased considerably in recent years (Table 1). [33–68] The renewed interest in electrochemical techniques can be attributed in part to more sophisticated instrumentation and increased understanding of the technique themselves. The application of different electrochemical modes in the analysis of drugs and pharmaceuticals are available for the quantification of drugs.…”

Polyethylenimine-Multi-Walled Carbon Nanotubes/Glassy Carbon Electrode as an Efficient Sensing Platform for Promethazine

“…[14][15][16] Phenothiazines are a large class of therapeutic agents, composed by a tricyclic structure containing nitrogen and sulfur, which are used as antipsychotic drugs for treating various mental and personality disorders. [17][18][19][20][21][22][23][24] Promethazine hydrochloride (PMZ) is one of the most consumed products of this class. PMZ has sedative, antipsychotic, antihistaminic, analgesic and anticholinergic properties.…”