Radioprotective effect of Terminalia Chebula Retzius extract against γ-irradiation-induced oxidative stress

Dixit, Deepti; Dixit, Amit Kumar; Lad, Harsha; Gupta, Damodar; Bhatnagar, Deepak

doi:10.1016/j.biomag.2012.10.008

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…The antioxidant activity of the T. arjuna bark was studied and the results of DPPH • assay, superoxide radical scavenging activity and lipid peroxidation assay were comparable with the standard antioxidant ascorbic acid [25]. T. chebula fruit extract possessed a potent antioxidant activity and can be used as a radio-protector as it protected from γ-irradiation-induced oxidative stress in rats by the reduction of radiation-induced cellular DNA damage [26].…”

Section: Antioxidant Activitymentioning

confidence: 90%

“…T. chebula fruit possess an extraordinary power of healing and is called the "King of Medicine" in Tibet as it's used for the treatment of various diseases [6,7]. The Bark of T. arjuna are used as cardioprotective and anti-hyperlipidemic in folklore medicine [8]. In Africa, T. mollis is used to treat diarrhea, gonorrhea, malaria, and in HIV treatment, while T. brachystemma is used for the treatment of shistosomiasis and gastrointestinal disorders [9].…”

Section: Introductionmentioning

confidence: 99%

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Genus Terminalia: A phytochemical and Biological Review

Nm¹,

Al‐Sayed²,

An³

2015

Med Aromat Plants

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Context: Terminalia is the second largest genus of family Combretaceae. The plants of this genus were used in traditional folk medicine worldwide.Objectives: This review is a comprehensive literature survey of different Terminalia species regarding their biological activities and their isolated phytochemicals. The aim of this review is to attract the attention to unexplored potential of natural products obtained from Terminalia species, thereby contributing to the development of new therapeutic alternatives that may improve the health of people suffering from various health problems.

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Section: Antioxidant Activitymentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Genus Terminalia: A phytochemical and Biological Review

Nm¹,

Al‐Sayed²,

An³

2015

Med Aromat Plants

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“…found the fruits of T. chebula against γ-irradiation-mediated oxidative stress in rats. The result showed that prior supplementation of T. chebula extracts caused a significant increase in the colony-forming unit (CFU) in the endogenous spleen, decreased radiation-induced cellular DNA damage in peripheral rat blood and reduced intestinal cell death [ 132 ]. The ability of T. chebula extract to protect the DNA integrity against radiation was also investigated where the original supercoiled formation of bacterial plasmid DNA (pBR322) was well maintained and thus, preventing strand breaks and necks formation [ 34 , 133 ].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz

Bulbul

Chowdhury

Naima

et al. 2022

Heliyon

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“…T. chebula fruit possesses an amazing power of healing and is called the "King of Medicine" in Tibet as it is used for the treatment of various illnesses [33,34]. The Bark of T. arjuna is used as cardioprotective and anti-hyperlipidemia in folklore treatment [35]. In Africa, T. mollis is used to treat gonorrhea, malaria, diarrhea, and HIV management, while T. brachystemma is used for the treatment of shistosomiasis and gastrointestinal complaints [36].…”

Section: Introductionmentioning

confidence: 99%

Chemical Profiling and Antimicrobial Properties of Phyto-Active Extracts from Terminalia glaucescens Stem Against Water Microbial Contaminants

Adeeyo¹,

Odiyo²,

Odelade³

2018

TOBIOTJ

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Background: The present study was designed to evaluate the phytochemicals of Terminalia glaucescens stem extracts and test their antimicrobial potency against water microbial contaminants reported to be multidrug resistant. Method: Dry stem powder was extracted with ethanol, ethyl acetate and chloroform. These fractions were then examined for antimicrobial activity by using disc diffusion assay against typical clinical bacteria and fungal isolates which have been reported as water contaminants. The microbial strains were exposed to five different concentrations of extracts: 500 mg/ml, 250 mg/ml, 100 mg/ml, 50 mg/ml and 25 mg/ml. Result: It was observed in this study that increase in the concentration of extracts correlated with microbial growth inhibition. In-vitro phytochemical screening of plant extracts revealed the presence of alkaloid, flavonoid, saponin, terpenoid, steroid and anthraquinones. Ethanolic extract performs better than ethyl acetate and chloroform extracts, as it recorded the highest zone of inhibition of 20.5 mm against Streptococcus pneumoniae while ethyl acetate and chloroform recorded 17.50 mm each against Streptococcus pneumoniae and Bacillus cereus, respectively. Ethanolic extract also showed the highest antifungal activity against Trichoderma sp. and Aspergillus niger. The antibacterial and antifungal activities of active extracts were observed in the increasing order Ethanol>Chloroform≥ethyl acetate with respect to the maximum zone of inhibition. Activity of crude extract from ethanol, when further compared with commercial antibiotics (Gentamicin, Streptomycin and Nystatin), was significantly higher. Conclusion: This plant crude extracts could therefore serve as potential source of new biocides with application in water research and other biotechnological fields.

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Radioprotective effect of Terminalia Chebula Retzius extract against γ-irradiation-induced oxidative stress

Cited by 9 publications

References 21 publications

Genus Terminalia: A phytochemical and Biological Review

Genus Terminalia: A phytochemical and Biological Review

A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz

Chemical Profiling and Antimicrobial Properties of Phyto-Active Extracts from Terminalia glaucescens Stem Against Water Microbial Contaminants

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