A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz

Bulbul, Md. Rakibul Hassan; Chowdhury, Mohammad Nizam Uddin; Naima, Taslima Anjum; Sami, Saad Ahmed; Imtiaj, Md. Shakil; Huda, Nazmul; Uddin, Md. Giash

doi:10.1016/j.heliyon.2022.e10220

Cited by 39 publications

(29 citation statements)

References 158 publications

(214 reference statements)

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“…The polyherbal formulation, Eye Mantra Drops, is a carefully crafted blend of thirteen traditionally used ingredients, each contributing unique pharmacological activities beneficial for ocular health. These ingredients include Rosa centifolia, known for its anti-inflammatory and antibacterial properties [16] ; Terminella chebula, recognized for its diverse range of activities such as antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and neuroprotective effects [19] ; T. belerica, acknowledged for its antioxidant, anti-inflammatory, and immuno-modulatory attributes, among others [20] ; Embelica officinalis, which boasts antioxidant, anticancer, and wound-healing properties [21] ; Ocimum sanctum, contributing to wound healing, radio-protective, and antiinflammatory actions [22] ; Boerhaavia diffusa, offering anti-inflammatory, antioxidant, and anticancer effects [23] ; Berberis aristata, with reported antibacterial, anti-inflammatory, and antioxidant activities [24] ; Curcuma longa, known for its antioxidant, anti-cancerous, and anti-inflammatory properties [25] ; Azadirachta indica, recognized for antioxidant, antiinflammatory, and immunomodulatory effects [26] ; Mentha avensis, providing antimicrobial, antioxidant, and immunomodulatory benefits [27] ; Glycerine, functioning as an osmotic dehydrating agent and contributing to lowering intraocular pressure in glaucoma [28] ; and Honey, with antioxidant, wound healing, and immunomodulatory properties [29] . These diverse pharmacological activities align with the reported potential benefits of Eye Mantra Drops in managing various ocular conditions, including conjunctivitis, iritis, dry eyes, itchy eyes, and watery eyes.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy and Safety of Eye Mantra Drops: A Comprehensive Post-Marketing Surveillance Study in Ocular Disorders

Shreya Verma,

Amrish Verma,

Jaspal Singh

et al. 2024

Int J Ayu Pharm Res

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Objectives: This study aimed to systematically evaluate the efficacy and safety of Eye Mantra Drops, a modern formulation integrating ayurvedic principles and medicinal plant extracts, in addressing various ocular conditions, including conjunctivitis, iritis, dry eyes, eye strain, itchiness, and watery eyes. Methods: The study adopted a single-center, open-label, non-randomized, post-marketing surveillance approach, involving 120 subjects with diverse ocular conditions. Eye Mantra Drops, comprising thirteen traditionally used ingredients, were administered to the participants for 7 days. Frequency and severity of symptoms, vital signs, and adverse events were assessed at screening and at the end of study to evaluate the safety and efficacy of Eye Mantra Drops. Results: The study revealed a significant reduction in frequency and symptom severity across diverse ocular conditions, including conjunctivitis, iritis, dry eyes, itchiness, watery eyes, and eye strain. No adverse events were reported, and vital signs remained stable, indicating the safety of Eye Mantra Drops. Conclusion: Eye Mantra Drops emerged as a promising and well-tolerated intervention for various ocular conditions including conjunctivitis, iritis, dry eyes, eye strain, itchiness, and watery eyes.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy and Safety of Eye Mantra Drops: A Comprehensive Post-Marketing Surveillance Study in Ocular Disorders

Shreya Verma,

Amrish Verma,

Jaspal Singh

et al. 2024

Int J Ayu Pharm Res

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“…T. chebula has a diverse chemical composition, mainly including tannins, polyphenols, triterpenoids, flavonoids, and other components ( Hassan Bulbul et al, 2022 ). We had previously conducted a network-based pharmacology analysis and screened 10 potential active components against RA, which mainly included polyphenols and alkaloids ( Fang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Liu

Zhan²,

Zhang³

et al. 2023

Front. Physiol.

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Background: The fruit of Terminalia chebula has been widely used for a thousand years for treating diarrhea, ulcers, and arthritic diseases in Asian countries. However, the active components of this Traditional Chinese medicine and their mechanisms remain unclear, necessitating further investigation.Objectives: To perform simultaneous quantitative analysis of five polyphenols in T. chebula and evaluate their anti-arthritic effects including antioxidant and anti-inflammatory activity in vitro.Materials and methods: Water, 50% water-ethanol, and pure ethanol were used as extract solvents. Quantitative analysis of gallic acid, corilagin, chebulanin, chebulagic acid, and ellagic acid in the three extracts was performed using high-performance liquid chromatography (HPLC). Antioxidant activity was assessed by the 2,2-diphenylpicrylhydrazyl (DPPH) radical-scavenging assay, and anti-inflammatory activity was evaluated by detecting interleukin (IL)-6 and IL-8 expression in IL-1β-stimulated MH7A cells.Results: The 50% water-ethanol solvent was the optimal solvent yielding the highest total polyphenol content, and the concentrations of chebulanin and chebulagic acid were much higher than those of gallic acid, corilagin, and ellagic acid in the extracts. The DPPH radical-scavenging assay showed that gallic acid and ellagic acid were the strongest antioxidative components, while the other three components showed comparable antioxidative activity. As for the anti-inflammatory effect, chebulanin and chebulagic acid significantly inhibited IL-6 and IL-8 expression at all three concentrations; corilagin and ellagic acid significantly inhibited IL-6 and IL-8 expression at high concentration; and gallic acid could not inhibit IL-8 expression and showed weak inhibition of IL-6 expression in IL-1β-stimulated MH7A cells. Principal component analysis indicated that chebulanin and chebulagic acid were the main components responsible for the anti-arthritic effects of T. chebula.Conclusion: Our findings highlight the potential anti-arthritic role of chebulanin and chebulagic acid from T. chebula.

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“…Die Erkenntnisse der Erfahrungsmedizin mit positiven klinischen Wirkungen von ayurvedischen Naturstoffen von 1988–1992 und die ersten Ergebnisse zum Wirkspektrum der Natursubstanzen ebenso wie die Zwischenschritte in biochemischen Studien von 2004–2016 können heute mehr als bestätigt werden. Dazu gehören Mistel, Lärchenkernholz, Myrobalan, Terminalia Chebula, Boswellia, Reishi, Cordyceps und Gojee (Galactose, Mannose), Curcumin mit den Wirksubstanzen Galactose/Arabinogalactan/Galectinen/Mannose 29 , 30 , 31 , 32 , 33 .…”

Section: Mitochondriale Wissenschaft Und Naturheilkundeunclassified

Die Rolle der Mitochondrien im Immunmetabolismus

Mosetter

2024

Erfahrungsheilkunde

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ZusammenfassungIn den Traditionen der ayurvedischen und chinesischen Medizin werden Erkrankungen mit Schwächezuständen, Müdigkeit, Depression, Neurodegeneration und Immundysregulation über „stärkende Naturstoffe“, aufbauende Maßnahmen für die Darmgesundheit, die „Lebergesundheit“ und einen guten Stoffwechsel behandelt. Nicht die Bekämpfung der Erkrankungen, sondern die Stärkung des natürlichen Energiestoffwechsels sowie der Reparatur stehen dabei im Vordergrund. Eine antientzündliche Ernährung mit verkochtem Gemüse, Linsen, Kichererbsen, Blumenkohl, Brokkoli und der Verzicht auf Toxine, Konservierungs- und Geschmacksverstärker, Zucker, Fruchtzucker, Getreide und Kuhmilchprodukte wird flankiert mit der Gabe von Myrobalan, Heidelbeeren, Goji-Beeren, Curcumin, Ingwer, Ginseng, Arabinogalactanen, Grüntee-Extrakten, Boswellia, Curcumin, Granatapfel, Cordyceps, Reishi, Artemisia usw. Ein gesunder Darm soll über den Stoffwechsel und die Leber den Energiehaushalt aufbauen. Könnte die Unterstützung der mitochondrialen Funktionen eine entscheidende Schnittstelle zwischen einer mehr als 3000 Jahre alten Erfahrungsmedizin und der modernen „Mitochondrien-Medizin“ darstellen?

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A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz

Cited by 39 publications

References 158 publications

Evaluating the Efficacy and Safety of Eye Mantra Drops: A Comprehensive Post-Marketing Surveillance Study in Ocular Disorders

Evaluating the Efficacy and Safety of Eye Mantra Drops: A Comprehensive Post-Marketing Surveillance Study in Ocular Disorders

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula

Die Rolle der Mitochondrien im Immunmetabolismus

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