Genus Terminalia: A phytochemical and Biological Review

Nm, Fahmy; Al‐Sayed, Eman; An, Singab

doi:10.4172/2167-0412.1000218

Cited by 8 publications

(8 citation statements)

References 75 publications

(82 reference statements)

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“…The genus Terminalia (Combretaceae) encounter around 200 different species growing in tropical area and in which at least 50 are used as food worldwide or as food supplements 7,8 . Healers traditionally use others to treat coughs, bronchitis, dysentery, fractures, sores, ulcers, hypertension, and ischaemic heart diseases i.e.…”

Section: Introductionmentioning

confidence: 99%

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Chahad¹,

Adey²,

Adawaye³

et al. 2021

Mediterr.J.Chem.,

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Based on a previous ethnobotanical survey, Terminalia macroptera Guill. & Perr. was selected as its heartwood is traditionally used for infections treatment and as mosquito repellent in the province of Ouaddai (Chad). In our course for a better knowledge of this medicinal plant which could be developed as phytomedicine, it is of great interest to subsequently characterize the chemical profile and bioactivities of this plant. In the present study we develop an Ultrahigh-performance liquid chromatography with diode array detection coupled to electrospray ionization and quadrupole time-of-flight (UHPLC-DAD-ESI/QTOF) technique to characterized on line potentially bioactive compounds. Thirteen compounds were identified in active extracts and fractions from Terminalia macroptera Guill. & Perr. heartwood, namely gallic and ellagic acids derivatives, 23-O-galloyl-terminolic acid, 23-O-galloyl arjunolic acid, 4,4’-dihydroxy-Z-stilbene-O-rutinoside and 3,5,4’-trihydroxy-Z-stilbene-O-rutinoside. Antibacterial properties were evaluated against sensitive and resistant Staphylococcus aureus strains and antioxidant activities using 1,1-diphenyl-2-picryl-hydrazyl (DPPH). Stilbene derivatives, 23-O-galloyl-terminolic acid and 23-O-galloyl arjunolic acid are newly reported in T. macroptera Guill. & Perr.

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Section: Introductionmentioning

confidence: 99%

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Chahad¹,

Adey²,

Adawaye³

et al. 2021

Mediterr.J.Chem.,

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“…Species of the genus Terminalia are known as a rich source of secondary metabolites, such as tannins (gallic acid and simple gallate esters; chebulic acid; chebulic and non-chebulic ellagitannins; ellagic acid and ellagic acid derivatives and glycosides), flavonoids (quercetin, kaempferol, rutin, luteolin, apigenin, vitexin, isovitexin, catechin, gallocatechin, epicatechin, epigallocatechin and leucocyanidin among others), phenolic acids (caffeic acid, ferulic acid, vanilic acid and coumaric acid among others), triterpenes (ursolic acid, asiatic acid, oleanolic acid, arjunic acid, arjunolic acid, β-sitosterol, stigmasterol and terminalin among others), triterpene glycosides (arjunetin, chebuloside, terminoside, sericoside, bellericoside and daucosterol) and lignans (isoguaiacin, termilignan, thannilignan and anolignan among others) (Fahmy et al, 2015). Garcez et al (2003) identified β-amirin and oleanolic acid in the ethanolic extract of the leaves of T. argentea, and, in the trunk bark, triterpenoids (tormentic acid β-D-glucopyranosyl ester and arjunetin), lignans (isoguaiacin) and flavones (7,3´-dihydroxy-4´-methoxyflavan, 7,4´-dihydroxy-3´-methoxyflavan, and catechin).…”

Section: Introductionmentioning

confidence: 99%

“…No pharmacological studies involving T. argentea were found in the databases consulted. However, in the polar and apolar extracts of leaves from other species of the Terminalia genus (T. chebula, T. catappa, T. prunioides, T. brachystemma, T. sericea, T. gazensis, T. mollis, T. sambesiaca, T. triflora, T. arjuna, T. muelleri, T. ferdinandiana and T. glaucescens), antioxidant, antifungal (Masoko et al, 2005), antibacterial, antiviral, anti-inflammatory, analgesic, antidiabetic, anticancer (Cock, 2015), wound healing (Fahmy et al, 2015), anti-Helicobacter pylori and antiulcer properties have been described (Silva et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Chemical characterisation and toxicity assessment in vitro and in vivo of the hydroethanolic extract of Terminalia argentea Mart. leaves

Beserra

Vilegas

Tangerina

et al. 2018

Journal of Ethnopharmacology

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Terminalia argentea Mart. (Combretaceae), known mainly as "capitão", is a native tree, not endemic, that occurs in the Amazon, Caatinga, Cerrado and Atlantic Forest in Brazil. Leaf infusion is popularly mentioned by riverine communities that inhabit the microregion of Northern Araguaia (Mato Grosso, Brazil) for the treatment of gastric ulcer, bronchitis and haemorrhage. Considering the wide medicinal use, lack of studies that evaluate the safety of use and the scarcity of phytochemical studies of T. argentea leaves, this work was carried out with the objective of evaluating the toxicity of the hydroethanolic extract of the leaves of T. argentea Mart. (HETa) in experimental models in vivo and in vitro, as well as to advance the phytochemical analysis of HETa. Materials and methods: HETa was prepared by macerating the leaf powder in hydroethanolic solution. Phytochemical characterisation was carried out by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and mass spectrometry through direct flow infusion coupled with electrospray ionization and ion-trap analyzer (DFI-ESI-IT-MS analyses) The contents of phenols, flavonoids and phytosterols were analysed by colorimetric methods. Cytotoxicity was assessed by the Alamar blue assay on Chinese hamster ovary epithelial cells (CHO-K1) and human gastric adenocarcinoma cells (AGS). In vitro genotoxicity of HETa (10, 30 or 100 μg/mL) was assessed by micronucleus (MN) and comet tests using CHO-K1 cells. The acute toxicity assessment was performed by oral administration of HETa in single dose Swiss mice (males and females) up to 2000 mg/kg and sub-chronic toxicity by daily oral administration of HETa (50, 200 and 800 mg/kg) in Wistar rats for 30 days. The parameters related to the clinical and toxicological observations were determined every 6 days and at the end of the treatment the blood was collected for biochemical and haematological analysis, and some organs were removed for macroscopic and histopathological analysis. Results: Preliminary phytochemistry and TLC analysis of HETa revealed the presence of phenolic compounds (18.8%), flavonoids (10.8%), saponins, tannins and phytosterols (19%). The HPLC data revealed the presence of gallic acid, rutin, ellagic acid, catechin, quercetin and kaempferol. In the analysis by DFI-ESI-IT-MS, the presence of gallic acid, rutin, ellagic acid and quercetin was confirmed and identified caffeic acid, quinic acid, galloylmucic acid, quercetin xyloside, quercetin rhamnoside, quercetin glucoside, caffeoyl ellagic acid, quercetin galloyl xyloside, terminalin, quercetin galloyl glucose, corilagin, quercetin digalloyl xyloside, quercetin digalloyl glucoside, punicalin and punicalagin. HETa showed no cytotoxic effect on CHO-K1 and AGS cells. In the MN assay, HETa increased the number of MNs and nuclear buds (NBUDs) in binucleate cells at the three concentrations tested and the nucleoplasmic bridges (NPBs) number at 30 μg/mL. In the comet test, HETa (10 and 100 μg/mL) alone showed a genotoxic effect on CHO-K1 cells. ...

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“…Arjunic acid (▶ Fig. 1 b), previously identified in the EtOAc extract of T. sericea roots [9], as well as in various parts of other Terminalia species [15,16], was found to be present in the methanol (MeOH) and EtOAc crude extracts. Anolignan B, a lignan compound, was detected in the MeOH and EtOAc crude extracts (▶ Fig.…”

Section: Resultsmentioning

confidence: 77%

“…2 b-d). Punicalagin is an ellagitannin containing a gallagyl-moiety that was originally isolated from the fruit peel of Punica granatum [18] and has been detected in various species of the Terminalia genus [15]. To the best of the authorsʼ knowledge, this is the first time the compound was detected in T. sericea.…”

Section: Resultsmentioning

confidence: 88%

Extracts of Terminalia sericea Enhance Cell Migratory Activity of Endothelial Hybrid and Fibroblast Cells In Vitro

et al. 2017

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is a plant that has been used amongst others medicinally to treat wounds. The aim of this study was to assess the wound healing ability of Hot water, methanol, ethyl acetate, and hexane extracts were prepared. Thin layer chromatography (TLC) and ultra-performance liquid chromatography time of flight mass spectrometry (UPLC-TOF-MS) were used to determine the phytochemical classes and genus specific compounds present in the plant. Cytotoxicity was assessed in the SC-1 fibroblast and EA.hy926 endothelial hybrid cell lines using the sulforhodamine B assay. The effect of the extracts on cellular migration in both cell lines was assessed using the scratch assay. The major phytochemical classes detected in the extracts using TLC were alkaloids, coumarins, flavonoids, glycosides, phenolics, saponins, sterols, and terpenoids. The genus-specific compounds punicalagin, sericoside, anolignan B, and arjunic acid were identified in the extracts by means of UPLC-QTOF-MS. Cytotoxicity was not observed after 24 h of exposure and a generally low cytotoxic trend was noted after 72 h. A significant (p < 0.05) enhancement of cell migration in both cell lines was noted in the scratch assay. The wound healing ability of is mainly attributed to the migratory and proliferative activity of the extracts responsible for the acceleration of wound closure. Isolation and individualized testing of the active compounds is warranted.

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Genus Terminalia: A phytochemical and Biological Review

Cited by 8 publications

References 75 publications

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Chemical characterisation and toxicity assessment in vitro and in vivo of the hydroethanolic extract of Terminalia argentea Mart. leaves

Extracts of Terminalia sericea Enhance Cell Migratory Activity of Endothelial Hybrid and Fibroblast Cells In Vitro

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