Chemical analysis and Biological properties of Terminalia macroptera Guill. &amp; Perr. from Eastern Chad

Chahad, Aouadalkarim Moussa; Adey, Souleymane Adam; Adawaye, Chatté; Zapfack, Louis; Dijoux‐Franca, Marie‐Geneviève

doi:10.13171/mjc02102121561saa

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Furthermore, significant derivatives of ellagic acid, together with triterpenes and saponins, are described in T. macroptera . This supports previous findings of some of these phyto-constituents being identified in the same plant collected from Chad [ 34 ].…”

Section: Discussionsupporting

confidence: 92%

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

Feunaing,

Tamfu,

Gbaweng

et al. 2024

Molecules

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Alzheimer’s disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are suitable therapies for AD, while α-amylase and α-glucosidase inhibitors are employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera and evaluated for their AChE, BChE, α-amylase, and α-glucosidase inhibitions. From 1H and 13C NMR data, the compounds were identified as 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-xylopyranoside (2), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-glucopyranoside (3), 3,3′-di-O-methyl ellagic acid-4-O-β-D-glucopyranoside (4), myricetin-3-O-rhamnoside (5), shikimic acid (6), arjungenin (7), terminolic acid (8), 24-deoxysericoside (9), arjunglucoside I (10), and chebuloside II (11). The derivatives of ellagic acid (1–4) showed moderate to good inhibition of cholinesterases, with the most potent being 3,3′-di-O-methyl ellagic acid, with IC50 values of 46.77 ± 0.90 µg/mL and 50.48 ± 1.10 µg/mL against AChE and BChE, respectively. The compounds exhibited potential inhibition of α-amylase and α-glucosidase, especially the phenolic compounds (1–5). Myricetin-3-O-rhamnoside had the highest α-amylase inhibition with an IC50 value of 65.17 ± 0.43 µg/mL compared to acarbose with an IC50 value of 32.25 ± 0.36 µg/mL. Two compounds, 3,3′-di-O-methyl ellagic acid (IC50 = 74.18 ± 0.29 µg/mL) and myricetin-3-O-rhamnoside (IC50 = 69.02 ± 0.65 µg/mL), were more active than the standard acarbose (IC50 = 87.70 ± 0.68 µg/mL) in the α-glucosidase assay. For α-glucosidase and α-amylase, the molecular docking results for 1–11 reveal that these compounds may fit well into the binding sites of the target enzymes, establishing stable complexes with negative binding energies in the range of −4.03 to −10.20 kcalmol−1. Though not all the compounds showed binding affinities with cholinesterases, some had negative binding energies, indicating that the inhibition was thermodynamically favorable.

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Section: Discussionsupporting

confidence: 92%

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

Feunaing,

Tamfu,

Gbaweng

et al. 2024

Molecules

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show abstract

“…Next, the proteins were prepared using AutoDock tools, which involved adding all hydrogen atoms to the macromolecule, a necessary step to calculate partial atomic charges correctly. Three-dimensional affinity grids were generated for each protein's active site, namely the Catalytic triad (Ser 203, His 447, Glu 334), Oxyanion hole (Gly121, Gly 122, Ala 204), Acyl pocket (Phe295, Phe297, Trp 236, Phe338), Anionic site (Trp86), and Peripheral site (Tyr72, Asp 74, Tyr124, Trp 286, Tyr341) [ 48 ] of size 60 × 58 × 68 Å with a spacing of 0.375 Å for the AChE protein, the GABA aminotransferase active site (Arg 192; Lys 203; Glu 265; Arg 445) of size 40 × 48 × 48 Å with a spacing of 0.375 Å, and the MOA A active site (Lys 305; Trp 397; Tyr 407; Tyr 444 [ 48 ]) of size 58 × 46 × 72 Å with a spacing of 0.375 Å [ 49 ]. These affinity grids were centered on the geometric center of the respective proteins.…”

Section: Methodsmentioning

confidence: 99%

Pterocarpus soyauxii (Fabaceae) aqueous extract to prevent neuropsychiatric disorders associated with menopause by triggering ROS-dependent oxidative damage and inhibiting acetylcholinesterase, GABA-transaminase, and monoamine oxidase A: In vitro, in vivo, and in silico approaches

Owona,

Mengue Ngadena,

Bilanda

et al. 2024

Heliyon

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Tannins-enriched fraction of TeMac™ protects against aluminum chloride induced Alzheimer's disease-like pathology by modulating aberrant insulin resistance and alleviating oxidative stress in diabetic rats

Akamba Ambamba,

Ella,

Ngassa Ngoumen

et al. 2024

Journal of Ethnopharmacology

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Chemical analysis and Biological properties of Terminalia macroptera Guill. & Perr. from Eastern Chad

Cited by 4 publications

References 25 publications

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)

Pterocarpus soyauxii (Fabaceae) aqueous extract to prevent neuropsychiatric disorders associated with menopause by triggering ROS-dependent oxidative damage and inhibiting acetylcholinesterase, GABA-transaminase, and monoamine oxidase A: In vitro, in vivo, and in silico approaches

Tannins-enriched fraction of TeMac™ protects against aluminum chloride induced Alzheimer's disease-like pathology by modulating aberrant insulin resistance and alleviating oxidative stress in diabetic rats

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