Quantitative histochemical mapping of candidate transmitter amino acids in cat cochlear nucleus.

Godfrey, Donald A.; Carter, Joyce A.; Berger, Sosamma J.; Lowry, Oliver H.; Matschinsky, Franz M.

doi:10.1177/25.6.18539

Cited by 102 publications

(31 citation statements)

References 38 publications

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“…In each case, GABA-and glycine-positive neuronal somata were seen to be concentrated in the DCN and in granule cell regions of the complex. A similar pattern of concentration of GABA and glycine has been shown with biochemical analysis (Fisher and Davies, 1976;Godfrey et al, 1977Godfrey et al, , 1978 and in studies of the distribution of GABA and glycine receptors (Altschuler et al, 1986;Frostholm and Rotter, 1986;Sanes et al, 1987;Glendenning and Baker, 1988;Wenthold et al, 1988;Juiz et al, 1989).…”

Section: Jk Moore Et Alsupporting

confidence: 54%

γ‐aminobutyric acid and glycine in the baboon cochlear nuclei: An immunocytochemical colocalization study with reference to interspecies differences in inhibitory systems

et al. 1996

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Previous studies of the cochlear nuclei in cat, rat, and guinea pig have demonstrated neural structures that are enriched in the inhibitory neurotransmitter amino acids gamma-aminobutyric acid (GABA) and glycine. In these mammals, inhibitory terminals are widely distributed throughout the nuclear complex, but somata of inhibitory neurons are concentrated in the dorsal cochlear nucleus, in granule cell regions, and in the cap area. Because these are the subdivisions that undergo the most pronounced phylogenetic changes in primates, we wanted to see whether the inhibitory systems are influenced by changes in cytoarchitecture. Therefore, we applied light microscopic postembedding immunostaining and optical densitometry to the cochlear nuclei of an anthropoid primate, the Senegalese baboon (Papio anubis). Our results demonstrate that, in baboon 1) glycinergic neurons and axons in the ventral cochlear nucleus seem to form a commissural system similar to that of other mammals; 2) the tuberculoventral system appears to be unchanged in morphology but exhibits a higher level of colocalization of GABA with glycine; 3) there is a reduction of the granule/cartwheel cell system, which is reflected in lesser numbers of inhibitory cartwheel, Golgi, and molecular layer stellate cells; 4) the cap area is larger than in rodents and carnivores and contains many neurons that colocalize GABA and glycine; and 5) throughout the nuclear complex, a higher proportion of the inhibitory terminals colocalize GABA and glycine. We conclude that modulation of the ascending auditory pathway in baboon is likely to differ from that in rodents and cat.

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Section: Jk Moore Et Alsupporting

confidence: 54%

γ‐aminobutyric acid and glycine in the baboon cochlear nuclei: An immunocytochemical colocalization study with reference to interspecies differences in inhibitory systems

et al. 1996

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“…The preponderance of receptor in these nuclei correlated well with the known levels of inhibitory function and, in the case of the cochlear nucleus, the levels of glycine (Godfrey et al, 1977(Godfrey et al, , 1978. In AVCN, LSO, and ICC there was a nonuniform distribution of binding that was aligned with the known tonotopic axes.…”

Section: Functional Implicationsmentioning

confidence: 63%

“…It is not surprising that 3H-SN binding is greatest in this auditory region, as is the concentration of glycine (Godfrey et al, 1977(Godfrey et al, , 1978. Preliminary iontophoretic results indicate that glycine is a potent inhibitor of tone-evoked activity in the DCN (Caspary et al, 1985).…”

Section: Functional Implicationsmentioning

confidence: 99%

“…The distribution of glycine has been histochemically quantified in the cochlear nuclei of both cat and rat (Godfrey et al, 1977, 1978). The results correlate well with the present results in that (1) glycine concentration is highest in the DCN, (2) glycine concentration is lowest in the PVCN, and (3) there is a small gradient of glycine concentration in the dorsoventral axis of AVCN.…”

Section: Anatomical Correlates To 'H-sn Bindingmentioning

confidence: 99%

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Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

et al. 1987

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The concentration and relative distribution of glycine receptors were determined for gerbil brain stem auditory nuclei using 3H-strychnine and quantitative autoradiographic techniques. Significant binding was observed in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the lateral superior olivary nucleus, and the inferior colliculus. A non-uniform distribution of binding was seen in 3 of these nuclei, such that the greatest concentration of glycine receptors was located in the high-frequency regions. An analysis of neuron soma density suggested that the amount of post-synaptic membrane could partially explain the distribution of receptor.

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“…Both types of principal cells receive excitatory glutamatergic input from spherical bushy cells of the CN on both sides of the brain (Godfrey et al, 1977;Perkins 1973;Stotler, 1953). Mariginal cells receive synaptic input either from the ipsilateral or the contralateral CN.…”

Section: Principal Nucleimentioning

confidence: 99%

Plasticity of the superior olivary complex

Illing

Kraus

Michler

2000

Microsc. Res. Tech.

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Quantitative histochemical mapping of candidate transmitter amino acids in cat cochlear nucleus.

Cited by 102 publications

References 38 publications

γ‐aminobutyric acid and glycine in the baboon cochlear nuclei: An immunocytochemical colocalization study with reference to interspecies differences in inhibitory systems

γ‐aminobutyric acid and glycine in the baboon cochlear nuclei: An immunocytochemical colocalization study with reference to interspecies differences in inhibitory systems

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

Plasticity of the superior olivary complex

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