Pure and zinc doped nano-hydroxyapatite: Synthesis, characterization, antimicrobial and hemolytic studies

Tank, Kashmira P.; Chudasama, Kiran S.; Thaker, Vrinda S.; Joshi, Mayank

doi:10.1016/j.jcrysgro.2014.01.062

Cited by 72 publications

(45 citation statements)

References 19 publications

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“…On the other hand, recent studies [35] proved that the cytotoxic and genotoxic mechanisms of HAp and zinc doped HAp are related to their membrane penetration capability and their apoptosis activity. In addition, recent studies showed that M. luteus, a Gram-positive bacteria, commonly found in mucous membranes, was highly inhibited by nanoHAp and doped nano-ZnHAp [42]. On the other hand, Huang et al [43] showed in their study on "anticorrosive effects and in vitro cytocompatibility of calcium silicate/zinc doped hydroxyapatite composite coatings on titanium" that the high cytocompatibility of calcium silicate/zinc doped hydroxyapatite could be mainly attributed to the combination of microporous surface effects and ion release (Zn…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Structural and Biological Assessment of Zinc Doped Hydroxyapatite Nanoparticles

Popa

Aur

Deniaud

et al. 2016

Journal of Nanomaterials

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The aim of the current research work was to study the physicochemical and biological properties of synthesized zinc doped hydroxyapatite (ZnHAp) nanoparticles with Zn concentrations Zn = 0 (HAp), Zn = 0.07 (7ZnHAp), and Zn = 0.1 (10ZnHAp) for potential use in biological applications. The morphology, size, compositions, and incorporation of zinc into hydroxyapatite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Raman scattering, and X-Ray Photoelectron Spectroscopy (XPS). In addition, the cytotoxicity of ZnHAp nanoparticles was tested on both E. coli bacteria and human hepatocarcinoma cell line HepG2. The results showed that ZnHAp nanoparticles (HAp, 7ZnHAp, and 10ZnHAp) have slightly elongated morphologies with average diameters between 25 nm and 18 nm. On the other hand, a uniform and homogeneous distribution of the constituent elements (calcium, phosphorus, zinc, and oxygen) in the ZnHAp powder was noticed. Besides, FTIR and Raman analyses confirmed the proper hydroxyapatite structure of the synthesized ZnHAp nanoparticles with the signature of phosphate, carbonate, and hydroxyl groups. Moreover, it can be concluded that Zn doping at the tested concentrations is not inducing a specific prokaryote or eukaryote toxicity in HAp compounds.

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Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Structural and Biological Assessment of Zinc Doped Hydroxyapatite Nanoparticles

Popa

Aur

Deniaud

et al. 2016

Journal of Nanomaterials

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“…Zn 2 þ doped HAs were synthesized to investigate their antimicrobial characteristics, microstructure, sintering behavior, and in-vivo responses [17][18][19][20][21]. It was shown that Zn incorporation into implants promotes bone formation around the implant and decreases the inflammatory response [16,22].…”

Section: Introductionmentioning

confidence: 99%

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Uysal

Severcan

Tezcaner

et al. 2014

Progress in Natural Science: Materials International

102

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Hydroxyapatite (HA) co-doped with Zn 2 þ and F À ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn 2 þ and F À ions incorporation into HA structure. Co-doping of Zn 2 þ and F À ions decreased unit cell volume of HA and decreased grain sizes. Zn 2 þ or 5 mol% F À addition into HA significantly improved its density. Microhardness was increased with Zn 2 þ addition and further increase was detected with F À co-doping. Zn 2 þ and F À co-doped samples had higher fracture toughness than pure HA. Zn 2 þ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F À addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.

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“…In Figure , for 1‐Cur‐HAP sample the presence of brushite phase is marked with B (JCPDF‐72‐0713) in the figure. The presence of curcumin during the synthesis facilitates some of the Ca 2+ ion to form brushite in the presence of HPO 4 2− ions . This brushite phase is clearly marked along with the minor curcumin phase as indicated with C in the 1‐Cur‐HAP sample in Figure .…”

Section: Resultsmentioning

confidence: 88%

“…According to earlier reports the pure curcumin suppressed the activity of many bacteria such as Staphylococcus aureus , Salmonella paratyphi and Bacillus subtilis , B. macerans, B. licheniformis and Azotobacter . Previously, Tank et al . reported antibacterial activity of pure and metal doped HAP nano‐particles against different micro‐organisms.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of novel bio‐material: Nano composites of hydroxyapatite and curcumin

Jogiya

Chudasama

Thaker

et al. 2017

Int J Applied Ceramic Tech

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Hydroxyapatite/curcumin nano-composites were synthesized by surfactant mediated approach. As hydroxyapatite is a bio-mineral with various bio-medical applications, the composites were made with natural pigment curcumin having numerous therapeutic applications and characterized it using various analytical techniques like powder XRD, FT-IR, TEM, TGA, CHN, and Impedance spectroscopic studies. Impedance spectroscopy study suggested the effect of grain and grain boundary for pure hydroxyapatite, while only the grain effect was observed for the composites. Hemolytic and antimicrobial activities were also carried out suggesting that the samples were safer to use medically. The bio-activity study was conducted using Simulated Body Fluid (SBF) in vitro indicating increased bio-activity in terms of increased formation of apatite layer. K E Y W O R D Scurcumin, hydroyapatite, nano-composite

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Pure and zinc doped nano-hydroxyapatite: Synthesis, characterization, antimicrobial and hemolytic studies

Cited by 72 publications

References 19 publications

Structural and Biological Assessment of Zinc Doped Hydroxyapatite Nanoparticles

Structural and Biological Assessment of Zinc Doped Hydroxyapatite Nanoparticles

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Synthesis and characterization of novel bio‐material: Nano composites of hydroxyapatite and curcumin

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