Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Abstract

Hydroxyapatite (HA) co-doped with Zn 2 þ and F À ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn 2 þ and F À ions incorporation into HA structure. Co-doping of Zn 2 þ and F À ions decreased unit cell volume of HA and decreased grain sizes. Zn 2 þ or 5 mol% F À addition into HA significantly improved its density. Microhardness was increased with Zn 2 þ addition and further increase was detected with F À co-doping. Zn 2 þ and F À co-doped samples had higher fracture toughness than pure HA. Zn 2 þ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F À addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

“…8 Similarly, biological and mechanical properties of Zn 21 /F 2 ions codoped HA were improved compared to pure HA. 9 In the same way, HA doped with Mn 21 /SiO 42 4 ions had a better ability to form new apatite layer than pure HA. 10 In another study, it was reported that Cu 21 /F 2 ions substitution in HA Correspondence to: Z. Evis; Department of Engineering Sciences, Middle East Technical University, 06800 Ankara, Turkey.…”

Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

“…A wide variety of anions, cations and functional groups, such as Na + [9], Sr 2+ [10], Zn 2+ [11], Mn 2+ [12], SiO 4 4− [13], F − [14], Cl − [15], and CO 3 2− [16], can be introduced into the single phase HA lattice. Amongst these substitutions, zinc and fluorine are widely considered as potential substituents because of their biological relevance [17]. Zn-containing HA has been developed to strengthen its osteoconductive characteristics that are induced by the pharmacological effect of Zn.…”

“…Zn-HA coatings deposited using an electrochemical process improve the differentiation and proliferation of osteoblasts and can thus potentially increase implant osteointegration [18]. Zn 2+ -substituted HA was synthesised to investigate its microstructure, sintering behaviour, antimicrobial characteristics and in vivo biocompatibility [17]. Zn incorporation into implants was shown to stimulate bone formation around the implant and reduce inflammatory response [17].…”

“…Zn 2+ -substituted HA was synthesised to investigate its microstructure, sintering behaviour, antimicrobial characteristics and in vivo biocompatibility [17]. Zn incorporation into implants was shown to stimulate bone formation around the implant and reduce inflammatory response [17]. Recent studies have shown that Zn-doped HA coating can release trace Zn 2+ in the degradation process, which is favourable to improve cell proliferation [11,17,18].…”

“…properties of HA particles [17]. However, to the best of our knowledge, the deposition of Zn 2+ and F − (Zn/F) co-doped HA (ZnFHA) coating on Ti-cp has not been sufficiently investigated.…”