Pulmonary Micro-Ecological Changes and Potential Microbial Markers in Lung Cancer Patients

Ran, Zhuonan; Liu, Jiexing; Wang, Fen; Xin, Caiyan; Xiong, Bin; Song, Zhimin

doi:10.3389/fonc.2020.576855

Cited by 11 publications

(7 citation statements)

References 90 publications

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“…Numerous investigations had indicated that the lung microbiota played multiple essential roles in lung diseases (27)(28)(29)(30)(31). However, previous studies had limitations in their characteristics to provide strong evidence, such as small sample size and lack of compliance with modern methodological research standards.…”

Section: Discussionmentioning

confidence: 99%

Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Chai

Wang

et al. 2022

Front. Med.

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Objective:Lung microbiota is increasingly implicated in multiple types of respiratory diseases. However, no study has drawn a consistent conclusion regarding the relationship between changes in the microbial community and lung diseases. This study verifies the association between microbiota level and lung diseases by performing a meta-analysis.Methods:Literature databases, including PubMed, ISI Web of Science, Embase, Google Scholar, PMC, and CNKI, were used to collect related articles published before March 20, 2021. The standard mean deviation (SMD) and related 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup, sensitivity, and publication bias analyses were also conducted.Results:Six studies, comprising 695 patients with lung diseases and 176 healthy individuals, were included in this meta-analysis. The results indicated that the microbiota level was higher in patients with lung diseases than in healthy individuals (SMD = 0.39, 95% CI = 0.22–0.55, I2 = 91.5%, P < 0.01). Subgroup analysis based on country demonstrated that the microbiota level was significantly higher in Chinese (SMD = 1.90, 95% CI = 0.87–2.93, I2 = 62.3%, P < 0.01) and Korean (SMD = 0.24, 95% CI = 0.13–0.35, I2 = 78.7%, P < 0.01) patients with lung diseases. The microbiota level of patients with idiopathic pulmonary fibrosis (IPF) (SMD = 1.40, 95% CI = 0.42–2.38, I2 = 97.3%, P = 0.005), chronic obstructive pulmonary disease (COPD) (SMD = 0.30, 95% CI = 0.09–0.50, I2 = 83.9%, P = 0.004), and asthma (SMD = 0.19, 95% CI = 0.06–0.32, I2 = 69.4%, P = 0.004) were significantly higher than those of the healthy group, whereas a lower microbiota level was found in patients with chronic hypersensitivity pneumonitis (CHP). The microbiota level significantly increased when the disease sample size was >50. Subgroup analysis based on different microbiota genera, indicated that Acinetobacter baumannii and Pseudomonas aeruginosa were significantly increased in COPD and asthma diseases.Conclusion:We observed that patients with IPF, COPD, and asthma had a higher microbiota level, whereas patients with CHP had a lower microbiota level compared to the healthy individuals. The level of A. baumannii and P. aeruginosa were significantly higher in patients with COPD and asthma, and thus represented as potential microbiota markers in the diagnosis and treatment of lung diseases.

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Section: Discussionmentioning

confidence: 99%

Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Chai

Wang

et al. 2022

Front. Med.

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“…In addition, Veillonella , Megasphaera , and Streptococcus presented a remarkably higher content in lung cancer patients than in healthy individuals. Similarly, Neisseria , Staphylococcus , and Dialister showed a higher level in lung cancerous lesions than in normal lung tissues ( Ran et al., 2020 ). However, different from the present study, one report found that Proteobacteria , Actinobacteria , and Firmicutes predominantly promoted the development of COPD by contributing the biosynthesis of palmitate, homocysteine, and urate ( Wang et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, different microorganisms cause different host immune responses. However, the microbiome not only acts on the organism by immunity responses, inflammation response, or metabolism mechanism, but also on the colonized organs locally ( Ran et al., 2020 ). For instance, fungal colonization and bacterial flora colonization were interacted with each other, which promoted the mycelial growth of fungi through colonized bacteria secreting antifungal substances and easily causing impaired lung infection ( Oever & Netea, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Ruan

Deng²,

Dong³

et al. 2021

Front. Cell. Infect. Microbiol.

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Although many studies have reported that microbiota emergencies are deeply involved in the occurrence and subsequent progression of lung diseases, the present diagnosis of lung disease depends on microbiota markers, which is still poorly understood. Therefore, a meta-analysis was performed to confirm lung microbiota markers for the diagnosis of lung diseases. Literature databases were searched following the inclusion and exclusion criteria. There are 6 studies including 1347 patients and 26 comparisons to be enrolled, and then the diagnostic effect was evaluated using Stata 14.0 and Meta-disc 1.4 software. The pooled sensitivity (SEN), specificity (SPE), diagnostic likelihood ratio positive (DLR+), diagnostic likelihood ratio negative (DLR−), and diagnostic OR (DOR), as well as area under the curve (AUC) of microbiota markers in the diagnosis of lung diseases were 0.90 (95% CI: 0.83-0.94), 0.89 (95% CI: 0.76-0.95), 7.86 (95% CI: 3.39-18.21), 0.12 (95% CI: 0.06-0.21), 22.254 (95% CI: 12.83-39.59.14), and 0.95 (95% CI: 0.93-0.97), respectively. Subgroup analysis revealed that research based on Caucasian, adult, BAL fluid, PCR, pneumonia obtained higher AUC values. The microbiota markers have shown potential diagnosis value for lung diseases. But further large-scale clinical studies are still needed to verify and replicate the diagnostic value of lung microbiota markers.

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“…Aumento relativo de Granulicatella spp, Abiotrofia spp y Streptococcus spp en pacientes con cáncer de pulmón. (Ran et al, 2021) Carcinoma de células escamosas de cabeza y cuello.…”

Section: Gen 16s Arnr En Esputounclassified

Microbiota y su relación en el cáncer

Bigoni-Ordóñez

Anguisaca

Carpio³

2021

RECEIN

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La microbiota humana está conformada por una amplia diversidad de microorganismos que habitan nuestro cuerpo, desempeñando roles muy importantes en el mantenimiento de la homeostasis. Sin embargo, cada vez existe más evidencia que relaciona estados conformacionales de la microbiota con la etiología y fisiopatología de distintas enfermedades en el ser humano entre ellas el cáncer. En esta revisión se detallan algunas interacciones moleculares a través de las cuales la microbiota incide en la fisiopatología del cáncer, el papel del virioma y su posible aplicación como un potente tratamiento. Finalmente, entender la relación entre la microbiota y el cáncer, permitirá tanto una mejor comprensión de la carcinogénesis como el desarrollo de nuevas estrategias médicas y enfoques dirigidos a la prevención, tratamiento y diagnóstico de esta enfermedad de manera mucho más precisa.

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Pulmonary Micro-Ecological Changes and Potential Microbial Markers in Lung Cancer Patients

Cited by 11 publications

References 90 publications

Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis

Microbiota y su relación en el cáncer

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