Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Chai, Lan; Wang, Qi; Si, Caijuan; Gao, Wenyan; Zhang, Lun

doi:10.3389/fmed.2021.723635

Cited by 6 publications

(5 citation statements)

References 57 publications

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“…Simultaneously, vibrio vulnificus has an anti-inflammatory effect by inhibiting Kupffer cell proliferation ( Blériot et al., 2015 ), which is consistent with the pathogenesis of AR. According to research, Acinetobacter baumanni activates the Nod-like receptor NLRP3 via caspase-1 to promote the release of IL-1β and TNFα from macrophages, thereby inducing asthma ( Chai et al., 2022 ). Simultaneously, Acinetobacter has several virulence factors, including toxins that form pores, and its outer membrane protein A induces dendritic cells to produce ROS, which can activate NLRP3 and promote immune responses such as asthma and allergic rhinitis ( Kang et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Microbial characterization of the nasal cavity in patients with allergic rhinitis and non-allergic rhinitis

Che

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionAlthough recent studies have shown that the human microbiome is involved in the pathogenesis of allergic diseases, the impact of microbiota on allergic rhinitis (AR) and non-allergic rhinitis (nAR) has not been elucidated. The aim of this study was to investigate the differences in the composition of the nasal flora in patients with AR and nAR and their role in the pathogenesis.MethodFrom February to September 2022, 35 AR patients and 35 nAR patients admitted to Harbin Medical University’s Second Affiliated Hospital, as well as 20 healthy subjects who underwent physical examination during the same period, were subjected to 16SrDNA and metagenomic sequencing of nasal flora.ResultsThe microbiota composition of the three groups of study subjects differs significantly. The relative abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity of AR patients was significantly higher when compared to nAR patients, while the relative abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. In addition, Lactobacillus murinus and Lacttobacillus kunkeei were also negatively correlated with IgE, while Lacttobacillus kunkeei was positively correlated with age. The relative distribution of Faecalibacterium was higher in moderate than in severe AR patients. According to KEGG functional enrichment annotation, ICMT(protein-S-isoprenylcysteine O-methyltransferase,ICMT) is an AR microbiota-specific enzyme that plays a role, while glycan biosynthesis and metabolism are more active in AR microbiota. For AR, the model containing Parabacteroides goldstemii, Sutterella-SP-6FBBBBH3, Pseudoalteromonas luteoviolacea, Lachnospiraceae bacterium-615, and Bacteroides coprocola had the highest the area under the curve (AUC), which was 0.9733(95%CI:0.926-1.000) in the constructed random forest prediction model. The largest AUC for nAR is 0.984(95%CI:0.949−1.000) for the model containing Pseudomonas-SP-LTJR-52, Lachnospiraceae bacterium-615, Prevotella corporis, Anaerococcus vaginalis, and Roseburia inulinivorans.ConclusionIn conclusion, patients with AR and nAR had significantly different microbiota profiles compared to healthy controls. The results suggest that the nasal microbiota may play a key role in the pathogenesis and symptoms of AR and nAR, providing us with new ideas for the treatment of AR and nAR.

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Section: Discussionmentioning

confidence: 99%

Microbial characterization of the nasal cavity in patients with allergic rhinitis and non-allergic rhinitis

Che

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

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“…There is a correlation between microbiota levels and lung diseases[ 46 ]. By analyzing the 16S rDNA of microflora in BALF, we observed a decrease in some pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis

Lv,

Cui,

Wang

et al. 2023

World J Stem Cells

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BACKGROUND Acute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and mortality rates in patients due to the lack of effective specific treatments. Gut microbiota homeostasis, including that in ALI, is important for human health. Evidence suggests that the gut microbiota improves lung injury through the lung-gut axis. Human umbilical cord mesenchymal cells (HUC-MSCs) have attractive prospects for ALI treatment. This study hypothesized that HUC-MSCs improve ALI via the lung-gut microflora. AIM To explore the effects of HUC-MSCs on lipopolysaccharide (LPS)-induced ALI in mice and the involvement of the lung-gut axis in this process. METHODS C57BL/6 mice were randomly divided into four groups (18 rats per group): Sham, sham + HUC-MSCs, LPS, and LPS + HUC-MSCs. ALI was induced in mice by intraperitoneal injections of LPS (10 mg/kg). After 6 h, mice were intervened with 0.5 mL phosphate buffered saline (PBS) containing 1 × 10 6 HUC-MSCs by intraperitoneal injections. For the negative control, 100 mL 0.9% NaCl and 0.5 mL PBS were used. Bronchoalveolar lavage fluid (BALF) was obtained from anesthetized mice, and their blood, lungs, ileum, and feces were obtained by an aseptic technique following CO 2 euthanasia. Wright’s staining, enzyme-linked immunosorbent assay, hematoxylin-eosin staining, Evans blue dye leakage assay, immunohistochemistry, fluorescence in situ hybridization, western blot, 16S rDNA sequencing, and non-targeted metabolomics were used to observe the effect of HUC-MSCs on ALI mice, and the involvement of the lung-gut axis in this process was explored. One-way analysis of variance with post-hoc Tukey’s test, independent-sample Student’s t -test, Wilcoxon rank-sum test, and Pearson correlation analysis were used for statistical analyses. RESULTS HUC-MSCs were observed to improve pulmonary edema and lung and ileal injury, and decrease mononuclear cell and neutrophil counts, protein concentrations in BALF and inflammatory cytokine levels in the serum, lung, and ileum of ALI mice. Especially, HUC-MSCs decreased Evans blue concentration and Toll-like receptor 4, myeloid differentiation factor 88, p-nuclear factor kappa-B (NF-κB)/NF-κB, and p-inhibitor α of NF-κB (p-IκBα)/IκBα expression levels in the lung, and raised the pulmonary vascular endothelial-cadherin, zonula occludens-1 (ZO-1), and occludin levels and ileal ZO-1, claudin-1, and occludin expression levels. HUC-MSCs improved gut and BALF microbial homeostases. The number of pathogenic bacteria decreased in the BALF of ALI mice treated with HUC-MSCs. Concurrently, the abundances of Oscillospira and Coprococcus in the feces of HUS-MSC-treated ALI mice were significantly increased. In addition, ...

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“…Simultaneously, vibrio vulnificus has an anti-inflammatory effect by inhibiting Kupffer cell proliferation (Bleŕiot et al, 2015), which is consistent with the pathogenesis of AR. According to research, Acinetobacter baumanni activates the Nod-like receptor NLRP3 via caspase-1 to promote the release of IL-1b and TNFa from macrophages, thereby inducing asthma (Chai et al, 2022). Simultaneously, Acinetobacter has several virulence factors, including toxins that form pores, and its outer membrane protein A induces dendritic cells to produce ROS, which can activate NLRP3 and promote immune responses such as asthma and allergic rhinitis (Kang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The respiratory microbiota in animals affected by environmental factors also correlates with respiratory disease (Chai et al, 2022). In addition to human research, publications in this Research Topic also detect the microbial characteristics of bovine respiratory tract.…”

mentioning

confidence: 99%

Respiratory Microbiome in Health and Disease

Chai,

Zhao,

Ding

2023

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

Cited by 6 publications

References 57 publications

Microbial characterization of the nasal cavity in patients with allergic rhinitis and non-allergic rhinitis

Microbial characterization of the nasal cavity in patients with allergic rhinitis and non-allergic rhinitis

Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis

Respiratory Microbiome in Health and Disease

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