Pulmonary function correlates with arterial stiffness in asthmatic patients

Weiler, Zeev; Zeldin, Yuri; Magen, Eli; Zamir, Doron; Kidon, Mona

doi:10.1016/j.rmed.2009.09.004

Cited by 20 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the Alx@75% was significantly higher in the asthmatic group but different from other authors [8–10], there was no correlation between this index and the pulmonary function parameters and reversibility of airway obstruction in the asthmatic group. This suggests that, besides airway obstruction, there are other factors contributing to the higher incidence of cardiovascular outcomes in this population.…”

Section: Discussioncontrasting

confidence: 99%

“…Recent studies show an important association between the chronic systemic inflammation in asthma, and arterial stiffness, which is considered a prognostic factor and independent predictor of cardiovascular events [8, 9]. In young adults and children with asthma, arterial stiffness is inversely correlated to the percentage of forced expiratory volume in the first second (FEV 1 %) [9, 10], which demonstrating that correlation between pulmonary function and vascular stiffness is not limited to aging patients [11]. Moreover, it was observed that arterial stiffness tends to increase with asthma severity [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vascular function in asthmatic children and adolescents

et al. 2017

View full text Add to dashboard Cite

BackgroundEpidemiological studies have demonstrated an increased incidence of cardiovascular events in patients with bronchial asthma, but little is known about the relationship between asthma and vascular function. The purpose of this study was to evaluate endothelial function and arterial stiffness in children and adolescents with asthma.MethodsA cross-sectional controlled study was designed. Measurements of endothelial function and arterial stiffness in asthmatic (13.6 ± 0.6 years) and control groups (14.9 ± 0.7 years) were taken by the non-invasive peripheral arterial tonometry (EndoPAT2000) determined by using the natural logarithm of the reactive hyperemia index (LnRHI) and the augmentation index (AIx@75%), respectively. Patients with asthma were also administered two questionnaires to evaluate asthma control and quality of life. Exercise functional capacity was evaluated using the Shuttle Walking Test (SWT). Only male participants were included in the present study.ResultsLnRHI and the walked distance during the SWT were similar between groups (p = 0.23 and p = 0.50, respectively). AIx@75% was significantly higher in the asthmatic group (-7.75 ± 1.7) compared to the control group (-15.25 ± 1.8), p < 0.04. In the control group, the LnRHI correlated positively with baseline systolic blood pressure (r = 0.53, p = 0.02) and mean arterial pressure (r = 0.50, p = 0.03), age (r = 0.61, p = 0.007), weight (r = 0.63, p = 0.004) and height (r = 0.56, p = 0.015). Besides that LnRHI correlated with FVC (r = 0.69, p = 0.002), FEV1, (r = 0.53, p = 0.03) and negatively with Tiffeneau index (FEV1/FVC%, r = −0.49 p = 0.04). The LnRHI of the asthmatic group did not correlate with the different variables evaluated.ConclusionThe increased AIx@75% without changes in LnRHI in asthmatic patients could mean that an early detection of vascular impairment may precede endothelial dysfunction, and that different mechanisms may contribute to the pathogenesis and progression of cardiovascular events in this population. A large prospective and randomized controlled study should be done to evaluate the physiopathological mechanisms underlying the association between arterial stiffness and asthma.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-016-0488-3) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vascular function in asthmatic children and adolescents

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Our findings extend the relationship between impaired lung function and arterial stiffness from asthmatic adults [21,24] to the pediatric population in which asthma is highly prevalent. Nevertheless, a recent study found opposite results, showing that, in childhood, higher lung function is associated with higher arterial stiffness; this association was mainly explained by anthropometry [9].…”

Section: Discussionsupporting

confidence: 73%

Arterial stiffness is increased in asthmatic children

et al. 2014

View full text Add to dashboard Cite

show abstract

“…8 Sun et al 21 determined the brachial-ankle pulse wave velocity as a marker for early atherosclerotic changes among patients with persistence asthma, and they showed a significant increase in CRP among those patients. Weiler et al 22 found a positive correlation between asthma and on early vascular changes in young patients with asthma. Atherosclerosis is a progressive disease characterized by the accumulation of inflammatory cells, lipids, and connective tissue in the arteries.…”

Section: Discussionmentioning

confidence: 96%