Arterial stiffness is increased in asthmatic children

Steinmann, Markus; Abbas, Chiara; Singer, Florian; Casaulta, Carmen; Regamey, Nicolas; Haffner, Dieter; Fischer, Dagmar‐Christiane; Simonetti, Giacomo D.

doi:10.1007/s00431-014-2423-2

Cited by 25 publications

(22 citation statements)

References 24 publications

(28 reference statements)

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“…On the other hand, there is a scarcity of published data on the association between the childhood-onset asthma and atherosclerosis and only few studies evaluated elasticity in asthmatic children to date. Steinmann et al [16] showed an increased arterial stiffness in children with asthma using carotid-femoral pulse wave velocity measurements. Weiler et al [17] examined the arterial stiffness in peripheral large and small arteries and found no difference between the asthmatic adults and controls.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of stiffness, distensibility, and strain of the abdominal aorta in asthmatic children

Özkan¹,

Khosroshahi²,

Kılıç³

et al. 2016

Turk Gogus Kalp Dama

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Bu çalışmada astımlı çocuklarda aterosklerozun tespitinde kullanılabilen aort sertliği, esnekliği ve gerilimi ve bunların kalp fonksiyonları üzerindeki etkisi araştırıldı. Ça lış ma pla nı: Ocak 2012-Kasım 2014 tarihleri arasında astımlı toplam 21 çocuk hasta (11 erkek, 10 kız; ort. yaş 11.3±3.2 yıl; dağılım 6-15 yıl) ve 17 sağlıklı çocuk (10 erkek, 7 kız; ort. yaş 12.8±3.8 yıl; dağılım 7-16 yıl) çalışmaya alındı. Abdominal ultrasonografi ile abdominal aortun sertliği, esnekliği ve gerilimi hesaplandı. Tüm çocuklarda ekokardiyografi çekildi. Bul gu lar: Kontrollere kıyasla, astımlı grupta aort sertliği daha yüksek iken, esneklik ve gerilim değerleri daha düşüktü. Aort gerilimindeki farklılığın %30.3'ü astım, %22.5'i nabız basıncı, %21.8'i orta duvar kısalma fraksiyonu ve %17.2'si sol ventriküler meridyonel duvar stresi ile ilişkiliydi. Sol ventrikül kütle indeksi ile meridyonel duvar stresi (r= 0.934), miyokardiyal fiber stresi (r= 0.918) ve ölçülen fiber stresi için tahmini orta duvar fiber kısalması (r= 0.918) arasında güçlü ve doğrusal bir ilişki bulundu. Aort esnekliğindeki farklılığın %40.6'sı astım, %18'i sistolik kan basıncı ve %12.2'si meridyonel sistol sonu duvar stresi ile ilişkiliydi. Aort sertliğindeki farklılığın %24.7'si diyastolik kan basıncı, %20.3'ü ejeksiyon zamanı ve %17.4'ü yaş değişkeni ile ilişkili bulundu. So nuç:Çalışma sonuçlarımıza göre, astımlı çocuklarda aort esnekliği ve gerilimi azalırken, aort sertliği artmaktadır. Bu nedenle, astımlı çocukların ateroskleroz gelişimi açısından yakından takip edilmesini önermekteyiz.

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Section: Discussionmentioning

confidence: 99%

The evaluation of stiffness, distensibility, and strain of the abdominal aorta in asthmatic children

Özkan¹,

Khosroshahi²,

Kılıç³

et al. 2016

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

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“…[24] Meanwhile, an inverse correlation between FEV 1 and CFPWV in pediatric patients with mild-to-moderate asthma was demonstrated. [25] Patients with chronic obstructive pulmonary disease also have significantly higher CFPWV values. [24] Interestingly, decreased FEV 1 was shown to be significantly associated with enhanced arterial stiffness, as assessed by peripheral pulse pressure in the general population.…”

Section: Discussionmentioning

confidence: 99%

Age and cigarette smoking modulate the relationship between pulmonary function and arterial stiffness in heart failure patients

Hu²,

Gong³

et al. 2017

Medicine

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The aim of this study was to assess the relationship between arterial stiffness and pulmonary function in chronic heart failure (CHF).Outpatients previously diagnosed as CHF were enrolled between April 2008 and March 2010, and submitted to arterial stiffness measurement and lung function assessment. Spirometry was performed by measuring forced vital capacity (FVC), the fraction of predicted FVC, forced expiratory volume in 1 second (FEV1), the percentage of predicted FEV1 in 1 second, FEV1 to FVC ratio, and the percentage of predicted FEV1/FVC. Cardio-ankle vascular index (CAVI) was considered for the estimation of arterial stiffness.The 354 patients assessed included 315 nonsmokers, and were 68.2 ± 7.2 years’ old. Unadjusted correlation analyses demonstrated CAVI was positively related to age (r = 0.3664, P < 0.0001), and negatively related to body mass index (BMI, r = −0.2040, P = 0.0001), E/A ratio (r = −0.1759, P = 0.0010), and FEV1 (r = −0.2987, P < 0.0001). Stepwise multivariate regression analyses showed age (r2 = 0.2391, P < 0.0001), BMI (r2 = −0.2139, P < 0.0001), smoking (r2 = 0.1211, P = 0.0130), E/A ratio (r2 = −0.1082, P = 0.0386), and FEV1 (r2 = −0.2550, P < 0.0001) were independent determinants of CAVI. In addition, there is a significant interaction between CAVI and forced expiratory volume in 1 second (FEV1) in relation to age (Pint < 0.0001) and smoking (Pint = 0.0001). Meanwhile, pulmonary function was not associated with BMI or E/A ratio.These findings demonstrated that reduced pulmonary function is associated with the increased CAVI, and had an interactive effect with age and smoking on CAVI in patients with CHF.

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“…It was also found that a concurrent family history of hypertension and the frequency of attack of acute severe asthma did not seem to designate the status of blood pressure (21). Based on an earlier study, Steinmann et al found that arterial stiffness increased in children with mild and moderate asthma (22). Brachial-ankle pulse wave velocity tends to increase as the pathogenic condition aggravated in asthma (23).…”

Section: Discussionmentioning

confidence: 99%

Asthma and hypertension; a pilot study

Yousefichaijan¹,

Zahedi²,

Soheili³

et al. 2017

J Renal Inj Prev

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This study investigated the existence of a possible link between asthma and hypertension, hypothesizing that asthma could increase the risk of hypertension and determine whether the adjustment of asthma could decrease the frequency of hypertension. Introduction:Asthma is a medical condition characterized by narrowing the airways, swelling and deposition of extra mucus in the airways. This condition leads to difficulty in breathing and causes coughing, wheezing and shortness of breath.Objectives: This study attempted to find a probable link between asthma and hypertension. Patients and Methods: This is a case-control study which evaluated 100 asthma patients with 100 healthy children by comparison. The relationship between asthma and hypertension was analyzed using the SPSS software, version 18.00. The application of Student's t-test and chisquare test was based on whether the data is continuous or not. Results: It was found that the risk of hypertension in children is affected and increased by asthma. Conclusion: This study showed that asthma has a significant effect on the occurrence of hypertension.

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Arterial stiffness is increased in asthmatic children

Abstract: Arterial stiffness is increased in children with mild-to-moderate asthma. The association between impaired lung function and increased arterial stiffness suggests that severity of disease translates into detrimental effects on the cardiovascular system.

Cited by 25 publications

References 24 publications

The evaluation of stiffness, distensibility, and strain of the abdominal aorta in asthmatic children

The evaluation of stiffness, distensibility, and strain of the abdominal aorta in asthmatic children

Age and cigarette smoking modulate the relationship between pulmonary function and arterial stiffness in heart failure patients

Asthma and hypertension; a pilot study

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