PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from &lt;i&gt;Eclipta prostrata&lt;/i&gt; L.

Le, Duc Dat; Nguyen, Duc Hung; Sook, Eun; Lee, Jeong Hyung; Min, Byung Sun; Choi, Jae Sue; Woo, Mi Hee

doi:10.1248/bpb.b20-00994

Cited by 10 publications

(10 citation statements)

References 27 publications

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“…The CSF exhibited the highest phenolic content followed by ESF, CME, AQSF and PSF. The phenolic content of CME was reported earlier by Xiong et al, 2021;Le et al, 2021, which is consistent with our results. A number of phenolic compounds such as 4-hydroxy benzoic acid, chlorogenic acid, vanillic acid, protocatechuic acid, syringic acid, caffeic acid and its ethyl ester, ferulic acid ethyl ester etc.…”

Section: Resultssupporting

confidence: 94%

“…A number of phenolic compounds such as 4-hydroxy benzoic acid, chlorogenic acid, vanillic acid, protocatechuic acid, syringic acid, caffeic acid and its ethyl ester, ferulic acid ethyl ester etc. have been reported from the shoots of E. prostata (Zhang et al, 2001;Xiong et al, 2021;Le et al, 2021). Our results support that E. prostata is an important source of phenolics that might have potential health benefits.…”

Section: Resultssupporting

confidence: 87%

“…In previous study, a sufficient amount of flavonoid in the methanol fraction has been reported by Lee et al, 2009;Zhao et al, 2015;Li et al, 2018, which is consistent with our results. The common flavonoids such as luteolin, luteolin-7-O-β-D-glucoside, acacetin, kaempferol, kaempferol-7-O-α-D-ramnoside, quercetin and quercetin-3-O-b-D-glucoside etc have been isolated from the E. prostata by et al, (Zhao et al, 2015;Li et al, 2018;Xiong et al, 2021;Le et al, 2021). In this report we evaluated the highest content of flavonoid from CSF among the shoot extractives of E. prostata.…”

Section: Resultsmentioning

confidence: 99%

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Possible Role of Phenolics and Flavonoids in Antioxidant, Cytotoxic and Thrombolytic Activities of Eclipta prostata L.

et al. 2022

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Eclipta prostata (E. prostata) L, is a herbal medicinal plant, which is reported to contain phenolics and flavonoids, but very little is known about its bioactive potentials. In this report, we reexamined the phenols and flavonoid content and evaluated different bioactivities of organic soluble fractions from the shoots of E. prostata for the first time. Among the extractives, chloroform soluble fraction (CSF) possessed the highest content of phenols (156.03 ± 0.52 mg gallic acid equivalent /g of dry extract) and flavonoids (67.47 ± 0.56 mg quercetin equivalent /g of dry extract) and exhibited the most potent antioxidant properties in terms of total antioxidant capacity (198.71 ± 0.89 mg ascorbic acid equivalent/g of dry extract) and DPPH free radical scavenging ability (IC50; 17.68 ± 0.32 μg/ml). Similarly, CSF showed the highest cytotoxicity with LC50 values of 16.03±0.23 μg/ml, and thrombolytic activity with 36.06 ± 0.39% clot lysis. A significant correlation was observed between flavonoid content and total antioxidant capacity (r2 = 0.894, p < 0.05), while high correlation was seen between polyphenols and flavonoid content with free radical scavenging, total antioxidant capacity and cytotoxicity (r2 = 0.612 - 0.928). These findings suggest that E. prostata is a precious source of polyphenols having potential bioactivities, which could be utilized for the management of lifestyle diseases. Bangladesh Pharmaceutical Journal 25(2): 164-174, 2022 (July)

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Section: Resultssupporting

confidence: 94%

Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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Possible Role of Phenolics and Flavonoids in Antioxidant, Cytotoxic and Thrombolytic Activities of Eclipta prostata L.

et al. 2022

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“…The Korean variety of E. prostrata ethanolic extract prepared conventionally and using ultrasound as well as wedenolactone (a compound isolated from this plant) exhibited anti-inflammatory activity by reducing IL-6, TNF-α, and PGE 2 levels ( Lee, 2017 ). In another investigation, a series of flavonoid, flavonoid derivative, triterpenoid, and triterpenoid glycosides were isolated from this plant which reduced the NO level in LPS-stimulated RAW 264.7 cells in varying degrees, where 7- O -methylorobol-4′- O - β -D-glucopyranoside was found to be the most potent compound and reported as an inhibitor of IκB phosphorylation ( Le et al, 2020 ). The aqueous seed extract of the Sri Lankan variety of this plant dose-dependently inhibited denaturation of egg albumin ( Kannadas et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Akhtar

2022

Front. Pharmacol.

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Inflammatory diseases are considered major threats to human health worldwide. In Bangladesh, a number of medicinal plants have been used in traditional medicine from time immemorial in the treatment of diverse diseases, including inflammatory disorders. This assignment aims at providing the status of the medicinal plants of Bangladesh which are traditionally used in the management of inflammatory disorders and are investigated for their anti-inflammatory prospects using different preclinical studies and future research directions. The information of medicinal plants assembled in this review was obtained from a literature search of electronic databases such as Google Scholar, PubMed, Scopus, Web of Science and ScienceDirect up to December, 2020 from publications on plants investigated for their anti-inflammatory activities, in which the place of plant sample collection was identified as Bangladesh. Keywords for primary searches were “anti-inflammatory,” “Bangladeshi,” and “medicinal plants.” Criteria followed to include plant species were plants that showed significant anti-inflammatory activities in 1) two or more sets of experiments in a single report, 2) same or different sets of experiments in two or more reports, and, 3) plants which are traditionally used in the treatment of inflammation and inflammatory disorders. In this study, 48 species of medicinal plants have been reviewed which have been used in traditional healing practices to manage inflammatory disorders in Bangladesh. The mechanistic pathways of the in vivo and in vitro study models used for the evaluation of anti-inflammatory properties of plant samples have been discussed. Selected plants were described in further detail for their habitat, anti-inflammatory studies conducted in countries other than Bangladesh, and anti-inflammatory active constituents isolated from these plants if any. Medicinal plants of Bangladesh have immense significance for anti-inflammatory activity and have potential to contribute toward the discovery and development of novel therapeutic approaches to combat diseases associated with inflammation. However, the plants reviewed in this article had chiefly undergone preliminary screening and require substantial investigations including identification of active molecules, understanding the mechanism of action, and evaluation for safety and efficacy to be followed by the formulation of safe and effective drug products.

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“…Lupane skeleton and a ketone at C-3 of triterpenes would be essential for exerting a potent PPA inhibition in A. precatorius [ 34 ]. Triterpenoid glycosides having glucopyranosyl moiety are favorable for inhibiting PTP1B enzyme from E. prostrata [ 35 ]. Bitter-taste receptors of quassinoids may be a target as to induce lipolytic activity, the length of acyl side chain at 15-OH is important for the lipolytic activity of B. javanica [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Zhang

Arunachalam

Wang

et al. 2021

The Scientific World Journal

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Objectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC50 of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. Conclusions. P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.

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PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

Cited by 10 publications

References 27 publications

Possible Role of Phenolics and Flavonoids in Antioxidant, Cytotoxic and Thrombolytic Activities of Eclipta prostata L.

Possible Role of Phenolics and Flavonoids in Antioxidant, Cytotoxic and Thrombolytic Activities of Eclipta prostata L.

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

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