Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Zhang, Dongdong; Arunachalam, Karuppusamy; Wang, Yue‐Hu; Yang, Jun; Hein, Pyae Phyo; Mon, Aye Mya; Li, Jianwen; Inta, Angkhana; Yang, Xuefei

doi:10.1155/2021/1424675

Cited by 7 publications

(4 citation statements)

References 54 publications

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“…In Brazil, C. lindenii was used for the treatment of stingray wounds and other pathogenic infections. There is no pharmacological or phytochemical research has been reported on C. lindenii 12 .…”

Section: Discussionmentioning

confidence: 99%

“…The leaves, tubers, and other parts of C. lindenii were used therapeutically for stingray lesions in the regions of Brazil. However, no sufficient data has been found to reveal the presence of phytochemicals and pharmacological effects of C. lindenii in literature [ 12 ]. The underlying principle of the current research work is to explore the efficacy of organic extracts of C. lindenii with antiproliferative activity in response to the HepG2 (liver cancer) and normal HEK293T (human embryonic kidney 293T) cell lines.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

Kalsoom

Altaf

Ashraf

et al. 2022

BioMed Research International

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Data regarding the therapeutic potential of Caladium lindenii (C. lindenii) are insufficient. It becomes more important to explore plants as an alternative or palliative therapeutics in deadly diseases around the globe. The current study was planned to explore C. lindenii for its anticancer activity of ethanolic and hexane extracts of C. lindenii leaves against hepatic carcinoma (HepG2) and human embryonic kidney (HEK293T) cell lines. HepG2 and HEK293T cells were treated with 10, 50, 100, 200, and 400 μg/mL of ethanolic and hexane extracts of C. lindenii and were incubated for 72 h. Antiproliferative activity was measured by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide (MTT) assay, and percentage viability were calculated through crystal violet staining and cellular morphology by Floid Cell Imaging Station. The study showed ethanolic extract exhibiting a significantly higher antiproliferative effect on HepG2 ( IC 50 = 31 μg/mL) in a concentration-dependent manner, while HEK293T ( IC 50 = 241 μg/mL) cells showed no toxicity. Hexane extract exhibited lower cytotoxicity ( IC 50 = 150 μg/mL) on HepG2 cells with no effect on HEK293T ( IC 50 = 550 μg/mL). On the other hand, the percentage viability of HepG2 cells was recorded as 78%, 67%, 50%, 37%, and 28% by ethanolic extracts, and 88%, 80%, 69%, 59%, and 50% by hexane extracts at tested concentrations of both extracts. Toxicity assay showed significantly safer ranges of percentage viabilities in normal cells (HEK293T), i.e., 95%, 90%, 88%, 76%, and 61% with ethanolic extract and 97%, 95%, 88%, 75%, and 62% with hexane extract. The assay validity revealed 100% viability in the control negative (dimethyl sulfoxide treated) and less than 45% in the control positive (cisplatin) on both HepG2 and HEK293T cells. Morphological studies showed alterations in HepG2 cells upon exposure to >50 μg/mL of ethanolic extracts and ≥400 μg/mL of hexane extracts. HEK293T on the other hand did not change its morphology against any of the extracts compared to the aggressive changes on the HepG2 cell line by both extracts and positive control (cisplatin). In conclusion, extracts of C. lindenii are proved to have significant potential for cytotoxicity-induced apoptosis in human cancer HepG2 cells and are less toxic to normal HEK293T cells. Hence C. lindenii extracts are proposed to be used against hepatocellular carcinoma (HCC) after further validations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

Kalsoom

Altaf

Ashraf

et al. 2022

BioMed Research International

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“…Since it has been documented that medicinal plants of Myanmar have properties against diabetes, some species of this region were selected to investigate their effect on porcine pancreatic lipase inhibition and glucose uptake in 3T3-L1 adipocyte assays. The ethanolic extract of C. tiglium seeds showed the highest increase in glucose uptake at a concentration of 40 μg/mL, which could indicate a potential insulin-sensitizing effect [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Espinoza-Hernández

Moreno-Vargas

Andrade‐Cetto

2023

Plants

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Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the Croton genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all Croton species that have shown pharmacological effects against diabetes and describe their action mechanisms. Through a search of the literature, 17 species with hypoglycemic, antihyperglycemic, antilipidemic, antihypertensive, antioxidant, and anti-inflammatory effects were found. Among the mechanisms by which they exerted these effects were the inhibition of α-glucosidases, the promotion of insulin secretion, and the increase in glucose uptake. Interestingly, it was found that some of them may have antihyperglycemic properties, although there were no ethnopharmacological reports that support their traditional use. Moreover, others only presented studies on their hypoglycemic effect in fasting, so further works are encouraged to describe the mechanisms involved in lowering fasting blood glucose levels, such as hepatic glucose production, especially for C. cajucara, C. cuneatus, C. gratissimus var. gratissimus, C. guatemalensis, and C. membranaceus. It is expected that this review contributes to the plant science knowledge of the genus, and it can be used in future references on the identification and development of new molecules/phytomedicines that help in the treatment of diabetes.

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“…The root of C. teeta has a berberine content of 6-7%, while the stem and leaf have lower concentrations of 2.00-3.00% and 1.00-1.97%, respectively. 34 Chen et al 61 investigated the alkaloid content of C. teeta collected from three different habitats in Yunnan Province, China. The alkaloid content of C. teeta varied among habitats, with the highest levels for jatrorrhizine (6.07-7.76 mg/g), columbamine (1.58-1.73 mg/g), epiberberine (0.36-0.66 mg/g), coptisine (14.93-17.81 mg/g), palmatine (4.61-5.24 mg/g), and berberine (78.99-84.85 mg/g).…”

Section: Phytochemicals/main Elementsmentioning

confidence: 99%

Coptis teeta Wall.: A Comprehensive Overview of its Traditional Uses, Pharmacological Uses, Phytochemicals and Conservation

Chelleng,

Sonia,

Tamuly

2024

Future Integr Med

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Coptis teeta Wall. (C. teeta) is a herb that goes by the name "Mishmi Tita", and holds significant value as a medicinal plant for treating various health conditions. This endangered plant, listed in the Red Data Book, is commonly found in India, Nepal, Bhutan and China. The present review aims to comprehensively summarize the traditional, pharmaceutical, and phytochemical aspects of C. teeta, providing a foundation for researchers to explore this endangered plant, and take bold steps to conserve, cultivate, and promote awareness among local people. A thorough literature search was conducted on PubMed, Google Scholar, Research Gate, SciFinder, and the ISI Web of Knowledge, using the following terms: "Coptis teeta", "Coptis teeta Wall.", "Mishmi tita", "Rhizoma coptidis", "Chinese medicine from Coptis teeta", and "Traditional uses of Coptis teeta". A comprehensive examination of 69 articles published between 1982 and 2023 was conducted to explore the properties and traditional applications of C. teeta. It was found that this plant and its active compounds exhibit a range of effects, such as fighting against microbes, alleviating diarrhoea, lowering blood pressure, regulating heart rhythm, reducing inflammation, improving mood, treating trachoma, managing diabetes, providing pain relief, and countering reactions. A total of 27 compounds were identified in different parts of this plant, according to the surveyed literature. These have been traditionally utilized to address ailments, including conditions, eye disorders, skin issues, gastrointestinal troubles like constipation and jaundice, and urinary disorders. Furthermore, these have shown potential in cancer treatment and mitigating inflammation. C. teeta boasts diverse traditional uses and promising pharmacological activities due to its rich chemical composition. Berberine is the main constituent, and various communities utilize it for various ailments. While endangered, C. teeta offers exciting medicinal potential, warranting further research and sustainable conservation efforts. Cultivating the plant and raising public awareness are crucial steps towards its preservation.

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Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar

Cited by 7 publications

References 54 publications

In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Coptis teeta Wall.: A Comprehensive Overview of its Traditional Uses, Pharmacological Uses, Phytochemicals and Conservation

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