Psychosocial stress, somatoform dissociative symptoms and free testosterone in premature ejaculation

Abstract

One of the most common sexual dysfunctional diseases in adult males is premature ejaculation. So far, there is no evidence of how premature ejaculation is associated with psychosocial stress. We tested the relationship between neuroendocrine changes in patients with premature ejaculation and indicators of stress experience as a new psychosomatic hypothesis where psychosocial stress may significantly contribute to the aetiology of premature ejaculation. A total of 55 patients with premature ejaculation were included in the study. The control group consisted of 55 healthy men. The diagnosis of premature ejaculation was confirmed by a sexology examination, a history of patients and the values of the premature ejaculation diagnostic tool questionnaire. Comprehensive biochemical serum analysis was focused on the values of total testosterone, free testosterone, luteinising hormone, thyroid‐stimulating hormone, dehydroepiandrosterone sulphate, sex hormone‐binding globulin and a premature ejaculation diagnostic tool score with trauma symptom checklist and somatoform dissociation questionnaire. The results show significant Spearman correlations of trauma symptom checklist with the premature ejaculation diagnostic tool score (R = 0.84) and free testosterone (R = 0.62) and somatoform dissociation questionnaire with the premature ejaculation diagnostic tool score (R = 0.53) and free testosterone (R = 0.57). Spearman correlations of trauma symptom checklist with somatoform dissociation questionnaire show significant correlation (R = 0.54).

Delayed ejaculation in men with depressive disorders

“…Testosterone (T) is the primary male sex hormone and an anabolic steroid that plays a key role for T in the development of male reproductive tissues such as the testes and prostate. It also serves to promote secondary sexual characteristics and influences sexual behaviour (Fiala & Lenz, 2020).…”

Effect of increased prolactin and psychosocial stress on erectile function

“…In conclusion, the data obtained from this study point to a possible aetiology between hyperprolactinemia, stress and erectile dysfunction. There is a need to focus on further expanded research in this area, in particular in the field of sexual dysfunctions, dissociative symptoms and stress (Fiala and Lenz, 2020).…”

Orgasm and Ejaculation Disorders

“…Animal studies show the biological interactions between 5-HT, dopamine, and the hypothalamicpituitary axis. Specifically, the hypothalamicpituitary-thyroid axis is involved [22][23][24]. Corona et al and Carani et al reported a significant correlation between APE and suppressed thyroidstimulating hormone (TSH) and high thyroid hormone values [25][26][27][28].…”