Effect of increased prolactin and psychosocial stress on erectile function

Fiala, Luděk; Lenz, Jiří; Sajdlova, Rachel

doi:10.1111/and.14009

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…PRL is an important hormone that affects testosterone levels and its use in target tissues (Buvat et al, 1985). PRL is also a hormone that is closely related to stress (Fiala et al, 2021). Its levels can also be increased by antipsychotics, which have antidopaminergic effects (Milano et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Delayed ejaculation in men with depressive disorders

Fiala

Lenz

Havelka³

et al. 2022

Andrologia

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Delayed ejaculation (DE) is one of the most difficult disorders to diagnose from male sexual dysfunctions. It is characterized by a significant ejaculation delay or even an inability to achieve ejaculation (AE). It is a disorder that affects men, but it can also have a secondary effect on their wives/partners and possibly their ability to fertilize. The 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) describes this sexual disorder as ejaculation which is delayed or absent in at least 75% of sexual intercourse during at least 6 months of partner sexual activity without the man's desire (Abdel-Hamid & Ali, 2018). DE itself also brings anxiety and fear to men (Rowland et al., 2010). Delayed ejaculation can be defined as the time it takes a man to reach ejaculation during vaginal penetration. This time is called IELT (intravaginal ejaculation latency time). The 3rd International Sexual Medicine Consultation defined IELT as a period of 20-25 min during which sexual activity lasts. This time was chosen based on the average IELT obtained in studies in the general male population. Some studies report that the normal range for IELT in men is 4-10 min (Perelman, 2016). The exact pathogenesis of DE/AE is not yet known. There are studies that suggest that this sexual disorder may be caused by a congenital disorder, a genetic disease, surgical complications, hormonal disorders, prostate or seminal vesicles inflammations or diseases, or pelvic nerve disorders (Corona et al., 2011). Our study looked at one of the possible causes of DE/AE, and that is hyperprolactinemia caused by antidepressant treatment in depressive disorders. We evaluated the interrelationships between hyperprolactinemia, depressive disorder, and delayed ejaculation or anejaculation. Prolactin (PRL) levels often increase in patients treated with antidepressants. Some male sexual dysfunctions can also be frequently diagnosed in patients with hyperprolactinemia (Fiala, Lenz, Konecna,

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Section: Introductionmentioning

confidence: 99%

Delayed ejaculation in men with depressive disorders

Fiala

Lenz

Havelka³

et al. 2022

Andrologia

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“…The results of our study confirm the relationship between erectile dysfunction, elevated blood PRL levels, and symptoms of trauma and psychosocial stress and represent important findings regarding these relationships. There is evidence that intimate relationships are very sensitive and respond to unsatisfactory and traumatic events that negatively affect the relationship and may subsequently cause sexual disorders [16], such as erectile dysfunction [17]. PRL is considered a hormone whose levels may increase under stress and subsequently lead to an increase in erectile dysfunction [18].…”

Section: Discussionmentioning

confidence: 99%

“…Rastrelli reported a possible relationship between PRL levels, sexual dysfunction, and male fertility [19]. An association between anxiety and depressive symptoms in men with sexual dysfunction has also been found in the European population [17]. There are very few studies on the sexual health of elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Erectile Function in Men during the COVID-19 Pandemic

Fiala

2024

OBM Integr Complement Med

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This research focused on two age groups of men (under 40 and over 40 years) and their sexual function during the COVID-19 pandemic. Somatic examinations, including the measurement of hormone levels, were conducted on all patients. The subjects also completed two questionnaires and provided personal history data. The first questionnaire covered the evaluation of erectile function, while the second assessed psychosocial trauma and stress. The results in the first group (men under 40 years of age) showed a correlation between prolactin values and erectile function score results (R = 0.54), between erectile function score results and trauma and psychosocial stress symptoms (R = 0.49) and also between prolactin values and trauma and psychosocial stress symptoms (R = 0.53). The results in the second group (men over the age of 40) showed a correlation between prolactin values and erectile function score results (R = 0.42), between erectile function score results and trauma and psychosocial stress symptoms (R = 0.54) and between free testosterone level and erectile function score results (R = 0.32). These findings support the hypothesis of a different impact of stress on the development of erectile dysfunction in men under 40 and over 40 years of age during COVID-19.

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“…Предполагается, что непосредственное истощение дофамина в дофаминергических нейронах гипоталамуса может играть важную роль в нарушении мужского копулятивного цикла, особенно в снижении либидо [22]. Согласно данным литературы, гипопролактинемия достоверно ассоциируется с эректильной дисфункцией и преждевременной эякуляцией в общей популяции европейских мужчин, а также у мужчин с бесплодием [23,24]. Кроме того, у мужчин с нарушениями эрекции и эякуляции низкий уровень ПРЛ был идентифицирован как независимый предиктор частоты серьезных неблагоприятных сердечнососудистых событий и метаболического синдрома [25,26].…”

Section: пролактин и мужской копулятивный циклunclassified

Andrological aspects of prolactin secretion disorders

Tyuzikov,

Grekov,

Smirnov

2023

Androl. genit. hir.

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Since the discovery of prolactin, scientific and practical interest in it has been focused exclusively from the standpoint of female endocrinology and reproductology. At the same time, the physiology and pathophysiology of prolactin in men, due to the historically established interpretation of the functions of this hormone only as an endocrine regulator of the female reproductive system, have remained insufficiently studied for a long time. However, in recent decades, convincing scientific evidence has begun to accumulate that prolactin is just as important for men as for women. It has been shown that in both sexes prolactin not only exhibits important classical (reproductive) effects, but has a wide range of non-productive physiological functions in many organs and cells. In particular, to date, not only reproductive, but various hormonal-metabolic, psychosomatic, immune-inflammatory, sexual disorders caused by disorders of prolactin secretion (hypo- and hyperprolactinemia) have been described.The review article, based on the available modern literature, examines the general issues of endocrinology and physiology of prolactin in men, as well as the main andrological manifestations of disorders of its secretion by male reproduction, male sexual function and prostate gland.

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Effect of increased prolactin and psychosocial stress on erectile function

Cited by 12 publications

References 17 publications

Delayed ejaculation in men with depressive disorders

Delayed ejaculation in men with depressive disorders

Erectile Function in Men during the COVID-19 Pandemic

Andrological aspects of prolactin secretion disorders

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