Delayed ejaculation in men with depressive disorders

Abstract

Delayed ejaculation (DE) is one of the most difficult disorders to diagnose from male sexual dysfunctions. It is characterized by a significant ejaculation delay or even an inability to achieve ejaculation (AE). It is a disorder that affects men, but it can also have a secondary effect on their wives/partners and possibly their ability to fertilize. The 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) describes this sexual disorder as ejaculation which is delayed or absent in at least 75% of sexual intercourse during at least 6 months of partner sexual activity without the man's desire (Abdel-Hamid & Ali, 2018). DE itself also brings anxiety and fear to men (Rowland et al., 2010). Delayed ejaculation can be defined as the time it takes a man to reach ejaculation during vaginal penetration. This time is called IELT (intravaginal ejaculation latency time). The 3rd International Sexual Medicine Consultation defined IELT as a period of 20-25 min during which sexual activity lasts. This time was chosen based on the average IELT obtained in studies in the general male population. Some studies report that the normal range for IELT in men is 4-10 min (Perelman, 2016). The exact pathogenesis of DE/AE is not yet known. There are studies that suggest that this sexual disorder may be caused by a congenital disorder, a genetic disease, surgical complications, hormonal disorders, prostate or seminal vesicles inflammations or diseases, or pelvic nerve disorders (Corona et al., 2011). Our study looked at one of the possible causes of DE/AE, and that is hyperprolactinemia caused by antidepressant treatment in depressive disorders. We evaluated the interrelationships between hyperprolactinemia, depressive disorder, and delayed ejaculation or anejaculation. Prolactin (PRL) levels often increase in patients treated with antidepressants. Some male sexual dysfunctions can also be frequently diagnosed in patients with hyperprolactinemia (Fiala, Lenz, Konecna,

Psychological distress, emotion regulation, neuroticism, and sexual relationship on patients with temporary ejaculation failure in vitro fertilization-embryo transfer treatment

“…Long-term high psychological distress levels tend to produce more negative emotions, which may reduce men's sexual desire by stimulating the secretion of prolactin (Wang and Xue, 2021). Consistent with a previous study (Junsheng et al, 2013), the present study indicated that psychological distress could predicate the occurrence of TEF, the reason was that distress is thought relevant to sexual disorders or elevated prolactin levels (Fiala et al, 2022). Thus, applying the intervention such as yoga therapy and self-administered mindfulness reduced the psychological distress (Bai et al, 2019;Dumbala et al, 2020), which was a critical benefit for patients with assisted reproduction.…”