Orgasm and Ejaculation Disorders

Belladelli, Federico; Pozzi, Edoardo; Fallara, Giuseppe; Capogrosso, Paolo; Salonia, Andrea

doi:10.1007/978-3-031-11701-5_7

Cited by 1 publication

(3 citation statements)

References 95 publications

(110 reference statements)

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“…At the same time, in the paragigantocellular nucleus, serotonergic neurons inhibit ejaculation. 5,[8][9][10][11] When these neurons release serotonin into their synaptic space, this neurotransmitter interacts with the 5-HT2C receptor of the postsynaptic neuron, which causes the inhibition of ejaculation. In contrast, the absence of serotonin facilitates the ejaculatory process.…”

Section: Introductionmentioning

confidence: 99%

“…Long-life or acquired premature ejaculation elicits different emotional, cognitive, and behavioral consequences in men suggesting that neurobiological substrates between the two classifications may differ. 1,2,7,8,[10][11][12][13] The treatment for premature ejaculation currently uses SSRIs, which increase the synaptic levels of this neurotransmitter. 14 It is assumed that the ejaculatory process inhibition is due to their effect on the 5-HT2C receptor.…”

Section: Introductionmentioning

confidence: 99%

“…14,23 To further validate the predictive validity criterion and strengthen the power of our model, we decided to analyze whether other SSRIs, such as sertraline and fluoxetine, are capable of delaying rapid ejaculation in male rats when evaluated in the MPCA, as they do in men with premature ejaculation. 6,8,10 These SSRIs have been shown to increase the intravaginal ejaculatory latency time in men with premature ejaculation. 6,14,26 Therefore, the objective of our study was to confirm that the MPCA satisfies the criterion of predictive validity by assessing whether sertraline and fluoxetine can significantly delay rapid ejaculation in male rats when evaluated in the MPCA.…”

Section: Introductionmentioning

confidence: 99%

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Nuevo estudio para confirmar el criterio de validez predictiva en un modelo animal para evaluar la eyaculación precoz: efectos de la sertralina y la fluoxetina

Morales-Otal,

Torner-Aguilar,

Fernández-Ramírez

et al. 2023

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Premature ejaculation (PE) is a common sexual dysfunction worldwide, and animal models are used to characterize it. We developed a paradigm called the multiple partner choice arena (MPCA), consisting of 4 acrylic cylinders placed crosswise. Each cylinder contains a sexually experienced male rat, and a receptive female rat resides in the central space, able to choose any cylinder for copulation. We have suggested the MPCA as an animal model for assessing PE be-cause male rats in this paradigm display behavior similar to PE in men, achieving ejaculation in less time. This study aims to demonstrate whether the MPCA satisfies the predictive validity criterion, in which the effects of drugs in the animal model should closely resemble those observed in human medical disorders, such as PE. We investigated the effect of 2 SSRIs (SSRI), sertraline and fluoxetine, on male rats' rapid ejaculation in the MPCA. Two groups of male rats (n=8) were tested: saline, sertraline, and fluoxetine. Weekly doses of 1, 3, and 10 mg/kg/day for sertraline and fluoxetine were administered, while the saline group received only the vehicle. Each test involved four males from the same group, treated with identical drug doses, until achieving the first ejaculation in the MPCA. Fluoxetine and sertraline, at the 10 mg/kg dose, significantly prolonged the ejaculation latency. For this reason, the MPCA satisfies the predictive validity criterion as an animal model of PE.

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