PSXVI-27 Rosa Roxburghii Tratt extracts improves performance, enhances immune function and reduces oxidative stress in geese under heat stress.

Li, M; Li, W; G, Zhang; Cheng, Wenke; Guo, Liu; Liu, S; Yang, Chongwu

doi:10.1093/jas/sky404.734

Cited by 4 publications

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“…8,40,41 Many studies have indicated that arsenic could decrease the levels of CD3 + , CD4 + , and the CD4 + /CD8 + ratio in humans and rats, as well as disrupt the balance of Th17 and Treg cells in PBMCs of rats. 33,42,43 However, the specific mechanisms of arsenic-induced immune system damage have not yet been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…After RRTJ intervention, the levels of CD3 + , CD4 + , and the CD4 + /CD8 + ratio were increased by 6.58%, 5.11%, and 0.17%, respectively (all p < 0.05) than those in before intervention. 33 However, the specific mechanisms of RRTJ protection against immune system damage in arsenicosis patients remains unknown. As a traditional Chinese medicine and edible fruit and as a dietary supplement with potential immunoregulatory activities, 49 RRTJ was considered to be a healthy edible fruit to explore its protective effects and potential mechanism in arsenic-induced dysregulated inflammation response.…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulation of immune and inflammation responses, which is a common mechanism of disease occurrence, was involved in arsenic-induced skin, 56 liver 43 and kidney 42 damage; RRTJ can improve immune function in arsenic-poisoned rats and patients. 33,34 Therefore, it is necessary to study the role and possible mechanism of RRTJ in arsenic-induced Th17-related pro-inflammatory responses. Current data showed that RRTJ could decrease the number of Th17 cells in both PBMCs and CD4 + T cells (Figure 5), as well as the expression of pro-inflammatory related cytokines IL-17 and IL-6 (Figure 6) and Th17 cells-related transcription factor RORγt (Figure 7(a)).…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28][29][30][31] RRTJ retains the original nutrients and bioactive properties of RRT and can be used as a dietary supplement. 32 Some studies have found that RRTJ could effectively improve the immune function of rats-exposed to arsenic (RRTJ was used in 10 mL/kg for 45 d after cessation of arsenic exposure) and arseniasis patients (patients received 120 mL/d RRTJ orally for one month), 33,34 however, the mechanism has not been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

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Potential value and mechanism of Rosa roxburghii tratt juice on pro-inflammatory responses in peripheral blood of patients with arsenic poisoning

et al. 2022

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Increasing evidence supports the role of arsenic in dysregulated immune and inflammation responses, while, safe and effective treatments have not been fully examined. Rosa roxburghii Tratt (RRT), a traditional Chinese edible fruit with potential immunoregulatory activities, was considered as a dietary supplement to explore its protective effects and possible mechanism in arsenic-induced dysregulated inflammation responses. We enrolled 209 arsenicosis patients and 41 controls to obtain baseline data, including the degree of arsenic poisoning prior to the RRT juice (RRTJ) intervention. Then, based on criteria of inclusion and exclusion and the principle of voluntary participation, 106 arsenicosis patients who volunteered to receive treatment were divided into RRTJ (n = 53) and placebo (n = 53) groups randomly. After three months follow-up, 89 subjects (46 and 43 of the RRTJ and placebo groups, respectively) completed the study and were examined for the effects and possible mechanisms of RRTJ on the Th17 cells-related pro-inflammatory responses in peripheral blood mononuclear cells (PBMCs). The PBMCs had higher levels of Th17 and Th17-related inflammatory cytokines IL-17, IL-6, and RORγt. Furthermore, the gene expressions of STAT3 and SOCS3 in PBMCs increased and decreased, respectively. Conversely, RRTJ decreased the number of Th17 cells, secretion of IL-17, IL-6, RORγt, and relative mRNA levels of STAT3, and increased the transcript levels of SOCS3. This study provides limited evidence that possible immunomodulatory effects of RRTJ on the critical regulators, IL-6 and STAT3, of the Th17 cells in arsenicosis patients, which indicated that IL-6/STAT3 pathway might appear as a potential therapeutic target in arsenicosis.

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