Prussian blue nanoparticles induce myeloid leukemia cells to differentiate into red blood cells through nanozyme activities

Abstract

Many kinds of diseases cause serious anemia that is characterized by a significantly decreased number of circulating red blood cells. The key reason is that the terminal erythroid differentiation is...

Ultrasmall Prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting the ERK/AP-1 pathway

“…Based on above observation, 1 μg/ml USPBNPs was utilized in the subsequent experiments. It should be noted that the dose of USPBNPs in present study was much lower than that of PBNPs used in previously published work, 26,29,30 which can be attributed to its ultrasmall size.…”

“…25 In recent years, prussian blue nanoparticles (PBNPs) demonstrated efficient ability to remove excessive ROS by mimicking multiple enzymes and showed novel therapeutic role in skin wound healing, acute pancreatitis and anemia. [26][27][28][29][30] However, PBNPs still have shortcomings such as a relatively large size and weak catalytic activity. Fortunately, USPBNPs with a size of about 3.4 nm were successfully synthesized in our previous study, which exhibited a more intensive ability of scavenging ROS.…”

Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination‐Proteasome Degradation to Rescue Intervertebral Disc Degeneration

“…[ 10 ] Moreover, PBNPs cleared ROS in myeloid leukemia cells (K562), downregulated NFE2, upregulated GATA1, and differentiated cells into terminal erythrocytes. [ 11 ] PBNPs also cleared ROS in the intestine and decreased intestinal lesions in a dextran sulfate sodium (DSS)‐induced enteritis mouse model. [ 12 ] More interestingly, PBNPs enhanced the signal of MRI T1 images.…”

Nanozyme Impregnated Mesenchymal Stem Cells for Hepatic Ischemia-Reperfusion Injury Alleviation

“…However, the nanozyme activities of the PB were recently implicated in the differentiation of leukemia cells into red blood cells. 43 Therefore, we analyzed the maintenance of the stemness in PB-MSCs by gene expression analysis of pluripotency markers CXCR4, Nanog, Oct4, and Sox2 by qPCR analysis. The expressions of all four genes in the PB-MSCs were similar to their expressions in normal MSCs (Figure 2a).…”

“…So, the impregnation of PB nanozyme must not affect the pluripotency and multilineage differentiation ability of the MSCs. However, the nanozyme activities of the PB were recently implicated in the differentiation of leukemia cells into red blood cells . Therefore, we analyzed the maintenance of the stemness in PB-MSCs by gene expression analysis of pluripotency markers CXCR4 , Nanog , Oct4 , and Sox2 by qPCR analysis.…”