Protein Requirements of Healthy Pregnant Women during Early and Late Gestation Are Higher than Current Recommendations1–4

Stephens, Trina; Payne, Magdalene; Ball, Ronald O.; Pencharz, Paul B.; Elango, Rajavel

doi:10.3945/jn.114.198622

Cited by 66 publications

(80 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The methodology was based on previous IAAO studies (3,12). Graded test lysine intakes (range: 6-84 mg · kg −1 · d −1 ) from deficient to excess were tested individually on separate study days.…”

Section: Methodsmentioning

confidence: 99%

“…Development and expansion of placental, uterine and breast tissues, blood and extracellular fluid volume, and fuel for the fetus demand increased nutrient supply. Recently, using the indicator amino acid oxidation method (IAAO) we determined that protein requirements are higher by ∼25% during late stages (∼36 wk) of healthy human pregnancy, compared to early stages (∼16 wk) (3). Using the pig as a model, and the IAAO method, it has been shown that lysine, an indispensable amino acid, requirements are higher by almost 85% from early to late gestation (4), although to our knowledge no studies have been conducted to determine lysine requirements during human pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…Recent research has focused instead on applying novel tracer techniques involving the use of stable isotopes, such as the IAAO method, in the hope of establishing requirement estimates in various physiological conditions and vulnerable populations (9,10). The IAAO technique has been used to study amino acid requirements in adults (11,12), young children (13,14), and neonates (15,16), and protein requirements in pregnancy (3).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Payne

Stephens

Lim

et al. 2018

The Journal of Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Payne

Stephens

Lim

et al. 2018

The Journal of Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…During pregnancy, protein needs are different depending on the stage of gestation, with early stages requiring 1.2 g/(kg·day) and later stages of pregnancy requiring 1.5 g/(kg·day) (Stephens et al 2015). Moreover, a mean protein requirement of 1.3 g/(kg·day) has been reported in preadolescent school-aged children (Elango et al 2011).…”

Section: Protein and Amino Acid Requirementsmentioning

confidence: 99%

Recent developments in understanding protein needs – How much and what kind should we eat?

Pencharz

Elango

Wolfe

2016

Appl. Physiol. Nutr. Metab.

Self Cite

View full text Add to dashboard Cite

A novel method has been developed to determine protein requirements, which is called indicator amino acid oxidation (IAAO). This technique has been validated by comparison with the "gold standard" nitrogen balance. Using IAAO we have shown that minimum protein requirements have been underestimated by 30%-50%. The National Academy of Sciences has for macro-nutrients proposed "Acceptable Macronutrient Distribution Ranges", which for protein is 10% to 35% of total energy. In practice, we suggest 1.5-2.2 g/(kg·day) of a variety of high-quality proteins.Key words: protein, protein recommendations, protein requirements, amino acid requirements, protein quality, optimal protein intakes, energy, growth, lean body mass. Résumé :Une nouvelle méthode est élaborée pour la détermination des besoins protéiques; il s'agit de l'indicateur de l'oxydation des acides aminés (« IAAO »). Cette méthode est validée par comparaison au bilan azoté, la norme de référence. En utilisant l'IAAO, on démontre que les besoins protéiques sont sous-estimés de 30-50 %. La « National Academy of Sciences » suggère pour les macronutriments « l'Étendue des valeurs acceptables pour les macronutriments » dans laquelle les protéines représen-tent de 10 à 35 % de l'énergie totale. Dans la pratique, nous suggérons 1,5-2,2 g/(kg·jour) de protéines de haute qualité et de sources variées. [Traduit par la Rédaction]

show abstract

“…Since the first application of IAAO studies in humans to determine protein requirements in young men by Humayun et al (2007), several populations (school-age children, pregnant women, elderly women >65 years, and female octogenarians) have been studied using this novel technique (Elango et al 2011;Tang et al 2014;Rafii et al 2015;Stephens et al 2015). In each of the studied populations the mean protein requirements determined by IAAO method exceed the requirements determined by traditional nitrogen balance studies by ϳ30%-40% (Table 1).…”

Section: Iaao Studies To Determine Protein Requirementsmentioning

confidence: 99%

Protein: A nutrient in focus

Arentson-Lantz

Clairmont

Paddon‐Jones

et al. 2015

Appl. Physiol. Nutr. Metab.

Self Cite

View full text Add to dashboard Cite

Abstract:Protein is an essential component of a healthy diet and is a focus of research programs seeking to optimize health at all stages of life. The focus on protein as a nutrient often centers on its thermogenic and satiating effect, and when included as part of a healthy diet, its potential to preserve lean body mass. A growing body of literature, including stable isotope based studies and longer term dietary interventions, suggests that current dietary protein recommendations may not be sufficient to promote optimal muscle health in all populations. A protein intake moderately higher than current recommendations has been widely endorsed by many experts and working groups and may provide health benefits for aging populations. Further, consuming moderate amounts of high-quality protein at each meal may optimally stimulate 24-h muscle protein synthesis and may provide a dietary platform that favors the maintenance of muscle mass and function while promoting successful weight management in overweight and obese individuals. Dietary protein has the potential to serve as a key nutrient for many health outcomes and benefits might be increased when combined with adequate physical activity. Future studies should focus on confirming these health benefits from dietary protein with long-term randomized controlled studies.Key words: protein, requirement, IAAO, aging, sarcopenia, intake distribution, satiety, weight management.Résumé : Les protéines, des composantes essentielles d'un régime sain, sont au centre de programmes de recherche pour optimiser la santé à tous les stades de la vie. On met l'accent concernant les protéines en tant que nutriment surtout sur l'effet thermogène et rassasiant; intégrés dans un régime sain, les protéines pourraient préserver la masse corporelle maigre. De plus en plus d'études dont celles sur les isotopes stables et les interventions alimentaires à long terme suggèrent que les recommandations alimentaires actuelles en matière de protéines ne conviendraient pas à la promotion d'une santé musculaire optimale dans toutes les strates de la population. Un apport protéique modérément supérieur aux recommandations actuelles et soutenu par plusieurs experts et groupes de travail pourrait procurer des bienfaits sanitaires aux populations vieillissantes. De plus, la consommation de quantités modérées de protéines de haute qualité à chaque repas pourrait stimuler durant 24 h la synthèse des protéines musculaires et pourrait constituer une plateforme alimentaire favorisant le maintien de la masse et des fonctions musculaires tout en permettant une gestion du poids avec succès chez les personnes en surpoids et obèses. Les protéines alimentaires ont le potentiel de nutriments essentiels pour de nombreuses problématiques de santé et leurs bénéfices seraient accrus lorsque combinées à suffisamment d'activité physique. Les prochaines études devraient se concentrer sur la validation des bénéfices sanitaires des protéines alimentaires au moyen d'études à long terme contrôlées et aléatoires. [Traduit par l...

show abstract

Protein Requirements of Healthy Pregnant Women during Early and Late Gestation Are Higher than Current Recommendations1–4

Cited by 66 publications

References 34 publications

Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Lysine Requirements of Healthy Pregnant Women are Higher During Late Stages of Gestation Compared to Early Gestation

Recent developments in understanding protein needs – How much and what kind should we eat?

Protein: A nutrient in focus

Contact Info

Product

Resources

About